Imperial College London
Alternate

ProfessorMartynBoutelle

Faculty of Engineering, Department of Bioengineering

Associate Provost (Estates Planning)
 
 
 
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Contact

 

+44 (0)20 7594 5138m.boutelle Website CV

 
 
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Location

 

B208Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gowers:2019:10.1039/c9lc00400a,
author = {Gowers, S and Rogers, M and Booth, M and Leong, C and Samper, I and Phairatana, T and Jewell, S and Pahl, C and Strong, A and Boutelle, M},
doi = {10.1039/c9lc00400a},
journal = {Lab on a Chip},
pages = {2537--2548},
title = {Clinical translation of microfluidic sensor devices: Focus on calibration and analytical robustness},
url = {http://dx.doi.org/10.1039/c9lc00400a},
volume = {19},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We present approaches to facilitate the use of microfluidics outside of the laboratory, in our case within a clinical setting and monitoring from human subjects, where the complexity of microfluidic devices requires high skill and expertise and would otherwise limit translation. Microfluidic devices show great potential for converting complex laboratory protocols into on-chip processes. We demonstrate a flexible microfluidic platform can be coupled to microfluidic biosensors and used in conjunction with clinical microdialysis. The versatility is demonstrated through a series of examples of increasing complexity including analytical processes relevant to a clinical environment such as automatic calibration, standard addition, and more general processes including system optimisation, reagent addition and homogenous enzyme reactions. The precision and control offered by this set-up enables the use of microfluidics by non-experts in clinical settings, increasing uptake and usage in real-world scenarios. We demonstrate how this type of system is helpful in guiding physicians in real-time clinical decision-making.
AU  - Gowers,S
AU  - Rogers,M
AU  - Booth,M
AU  - Leong,C
AU  - Samper,I
AU  - Phairatana,T
AU  - Jewell,S
AU  - Pahl,C
AU  - Strong,A
AU  - Boutelle,M
DO  - 10.1039/c9lc00400a
EP  - 2548
PY  - 2019///
SN  - 1473-0189
SP  - 2537
TI  - Clinical translation of microfluidic sensor devices: Focus on calibration and analytical robustness
T2  - Lab on a Chip
UR  - http://dx.doi.org/10.1039/c9lc00400a
UR  - http://hdl.handle.net/10044/1/70734
VL  - 19
ER  -
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