Imperial College London
Alternate

ProfessorMartynBoutelle

Faculty of Engineering, Department of Bioengineering

Associate Provost (Estates Planning)
 
 
 
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Contact

 

+44 (0)20 7594 5138m.boutelle Website CV

 
 
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Location

 

B208Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gowers:2020:10.1039/C9AN01950B,
author = {Gowers, S and Samper, I and Murray, D-S and Smaith, G and Jeyaprakash, S and Rogers, M and Karlsson, M and Olsen, M and Moller, K and Boutelle, M},
doi = {10.1039/C9AN01950B},
journal = {The Analyst},
pages = {1894--1902},
title = {Real-time neurochemical measurement of dynamic metabolic events during cardiac arrest and resuscitation in a porcine model},
url = {http://dx.doi.org/10.1039/C9AN01950B},
volume = {145},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This work describes a fully-integrated portable microfluidic analysis system for real-time monitoring of dynamic changes in glucose and lactate occurring in the brain as a result of cardiac arrest and resuscitation. Brain metabolites are sampled using FDA-approved microdialysis probes and coupled to a high temporal resolution 3D printed microfluidic chip housing glucose and lactate biosensors. The microfluidic biosensors are integrated with a wireless 2 channel potentiostat forming a compact analysis system that is ideal for use in a crowded operating theatre. Data are transmitted to a custom-written app running on a tablet for real-time visualisation of metabolic trends. In a proof of-concept porcine model of cardiac arrest, the integrated analysis system proved reliable in a challenging environment resembling a clinical setting; noise levels were found to be comparable with those seen in the lab and were not affected by major clinical interventions such as defibrillation of the heart. Using this system, we were able, for the first time, to measure changes in brain glucose and lactate levels caused by cardiac arrest and resuscitation; the system was sensitive to clinical interventions such as infusion of adrenaline. Trends suggest that cardiopulmonary resuscitation alone does not meet the high energy demands of the brain as metabolite levels only return to their values preceding cardiac arrest upon return of spontaneous circulation.
AU  - Gowers,S
AU  - Samper,I
AU  - Murray,D-S
AU  - Smaith,G
AU  - Jeyaprakash,S
AU  - Rogers,M
AU  - Karlsson,M
AU  - Olsen,M
AU  - Moller,K
AU  - Boutelle,M
DO  - 10.1039/C9AN01950B
EP  - 1902
PY  - 2020///
SN  - 0003-2654
SP  - 1894
TI  - Real-time neurochemical measurement of dynamic metabolic events during cardiac arrest and resuscitation in a porcine model
T2  - The Analyst
UR  - http://dx.doi.org/10.1039/C9AN01950B
UR  - https://pubs.rsc.org/en/content/articlelanding/2020/AN/C9AN01950B#!divAbstract
UR  - http://hdl.handle.net/10044/1/76226
VL  - 145
ER  -
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