Imperial College London
Alternate

Professor Martin Buck FRS

Faculty of Natural Sciences, Department of Life Sciences

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 5442m.buck

 
 
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Location

 

448Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Liu:2021:10.1016/j.cell.2021.05.041,
author = {Liu, J and Tassinari, M and Naskar, S and Souza, D and Noel, J and Bohuszewicz, O and Buck, M and Williams, T and Baum, B and Low, H},
doi = {10.1016/j.cell.2021.05.041},
journal = {Cell},
pages = {3660--3673.e18},
title = {Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodelling superfamily},
url = {http://dx.doi.org/10.1016/j.cell.2021.05.041},
volume = {184},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Membrane remodeling and repair are essential for all cells. Proteins that perform these functions include Vipp1/IM30 in photosynthetic plastids, PspA in bacteria, and ESCRT-III in eukaryotes. Here, using a combination of evolutionary and structural analyses, we show that these protein families are homologous and share a common ancient evolutionary origin that likely predates the last universal common ancestor. This homology is evident in cryo-electron microscopy structures of Vipp1 rings from the cyanobacterium Nostoc punctiforme presented over a range of symmetries. Each ring is assembled from rungs that stack and progressively tilt to form dome-shaped curvature. Assembly is facilitated by hinges in the Vipp1 monomer, similar to those in ESCRT-III proteins, which allow the formation of flexible polymers. Rings have an inner lumen that is able to bind and deform membranes. Collectively, these data suggest conserved mechanistic principles that underlie Vipp1, PspA, and ESCRT-III-dependent membrane remodeling across all domains of life.
AU  - Liu,J
AU  - Tassinari,M
AU  - Naskar,S
AU  - Souza,D
AU  - Noel,J
AU  - Bohuszewicz,O
AU  - Buck,M
AU  - Williams,T
AU  - Baum,B
AU  - Low,H
DO  - 10.1016/j.cell.2021.05.041
EP  - 3673
PY  - 2021///
SN  - 0092-8674
SP  - 3660
TI  - Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodelling superfamily
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2021.05.041
UR  - https://www.sciencedirect.com/science/article/pii/S0092867421006966?via%3Dihub
UR  - http://hdl.handle.net/10044/1/90126
VL  - 184
ER  -
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