Imperial College London

ProfessorMariaCharalambides

Faculty of EngineeringDepartment of Mechanical Engineering

Professor of the Mechanics of Materials
 
 
 
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Contact

 

+44 (0)20 7594 7246m.charalambides Website

 
 
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Location

 

516City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kinloch:2018:10.1016/j.ejpb.2018.02.032,
author = {Kinloch, AJ and Rizi, K and Mohammed, IK and Charalambides, MN and Murdan, K and Xu, K},
doi = {10.1016/j.ejpb.2018.02.032},
journal = {European Journal of Pharmaceutics and Biopharmaceutics},
pages = {355--365},
title = {A systematic approach to the formulation of anti-onychomycotic nail patches},
url = {http://dx.doi.org/10.1016/j.ejpb.2018.02.032},
volume = {127},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Nail patches have a potential role as drug carriers for the topical treatment of nail diseases such as onychomycosis, a common condition. Our aim was therefore to develop a systematic and novel approach to the formulation of a simple drug-in-adhesive ungual patch. Twelve pressure-sensitive adhesives (PSAs), four backing membranes, two release liners and three drugs were screened for pharmaceutical and mechanical properties. From this initial screening, two PSAs, two drugs, one backing membrane and one release liner were selected for further investigation. Patches were prepared by solvent-casting and characterised. The patches had good uniformity of thickness and of drug content, and showed minimal drug crystallisation during six months of storage. Meanwhile, the drug stability in the patch upon storage and patch adhesion to the nail was influenced by thenature of the drug, the PSA and the backing membrane. The reported methodology paves the way for a systematic formulation of ungual nail patches to add to the armamentarium of nail medicines. Further, from this work, the best patch formulation has been identified.
AU - Kinloch,AJ
AU - Rizi,K
AU - Mohammed,IK
AU - Charalambides,MN
AU - Murdan,K
AU - Xu,K
DO - 10.1016/j.ejpb.2018.02.032
EP - 365
PY - 2018///
SN - 0939-6411
SP - 355
TI - A systematic approach to the formulation of anti-onychomycotic nail patches
T2 - European Journal of Pharmaceutics and Biopharmaceutics
UR - http://dx.doi.org/10.1016/j.ejpb.2018.02.032
UR - http://hdl.handle.net/10044/1/57820
VL - 127
ER -