Child lab Research Interests
Our lab uses modern chemical biology techniques to increase our understanding of the basic biology of intracellular pathogens such as Toxoplasma and Plasmodium.
We use drug-like small molecules to ask questions about the interaction of these pathogenic organisms with their chosen host-cell. We do this in the belief that by increasing our understanding we will be better equipped to target and therapeutically treat infections that impact human health.
For more information visit www.laboratorychild.com/
About Dr. Matthew Child
Matthew studied for a PhD in molecular parasitology with Prof. Mike Blackman at the National Institute for Medical Research, London, UK. Afterhis PhD, he moved to the USA to continue his academic career as a post-doc in the chemical biology-focused laboratory of Prof. Matt Bogyo at Stanford University, California.
Following his return to the UK, Matthew was awarded a Wellcome Trust and Royal Society Sir Henry Dale Fellowship, allowing him to initiate his independent research career and lab at Imperial College London.
et al., 2017, Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1, Mbio, Vol:8, ISSN:2150-7511
et al., 2015, A small-molecule antivirulence agent for treating Clostridium difficile infection, Science Translational Medicine, Vol:7, ISSN:1946-6234
et al., 2015, Design and Synthesis of Activity-Based Probes and Inhibitors for Bleomycin Hydrolase, Chemistry & Biology, Vol:22, ISSN:1074-5521, Pages:995-1001
et al., 2015, Global Analysis of Palmitoylated Proteins in Toxoplasma gondii, Cell Host & Microbe, Vol:18, ISSN:1931-3128, Pages:501-511
et al., 2014, The Calcium-Dependent Protein Kinase 3 of Toxoplasma Influences Basal Calcium Levels and Functions beyond Egress as Revealed by Quantitative Phosphoproteome Analysis, Plos Pathogens, Vol:10, ISSN:1553-7366