Publications
226 results found
Guo L, Salt TE, Maass A, et al., 2005, Activation of group II mGlu receptors is neuroprotective in retinal ganglion cell apoptosis in <i>in vivo</i> models of glaucoma, 5th International Meeting on Metabotropic Glutamate Receptors, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 247-248, ISSN: 0028-3908
Cordeiro MF, Guo L, Luong V, et al., 2004, Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration., Proc Natl Acad Sci U S A, Vol: 101, Pages: 13352-13356, ISSN: 0027-8424
Apoptotic nerve cell death is implicated in the pathogenesis of several devastating neurodegenerative conditions, including glaucoma and Alzheimer's and Parkinson's diseases. We have devised a noninvasive real-time imaging technique using confocal laser-scanning ophthalmoscopy to visualize single nerve cell apoptosis in vivo, which allows longitudinal study of disease processes that has not previously been possible. Our method utilizes the unique optical properties of the eye, which allow direct microscopic observation of nerve cells in the retina. We have been able to image changes occurring in nerve cell apoptosis over hours, days, and months and show that effects depend on the magnitude of the initial apoptotic inducer in several models of neurodegenerative disease in rat and primate. This technology enables the direct observation of single nerve cell apoptosis in experimental neurodegeneration, providing the opportunity for detailed investigation of fundamental disease mechanisms and the evaluation of interventions with potential clinical applications, together with the possibility of taking this method through to patients.
Cordeiro MF, Guo L, Luong V, et al., 2004, Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 101, Pages: 13352-13356, ISSN: 0027-8424
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- Citations: 216
Cordeiro MF, Alexander RA, Reichel MB, et al., 2003, Role of transforming growth factor β in conjunctival scarring (vol 104, pg 181, 2003), CLINICAL SCIENCE, Vol: 105, Pages: 723-723, ISSN: 0143-5221
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- Citations: 3
Wells AP, Cordeiro MF, Bunce C, et al., 2003, Cystic bleb formation and related complications in limbus- versus fornix-based conjunctival flaps in pediatric and young adult trableculectomy with mitomycin C, OPHTHALMOLOGY, Vol: 110, Pages: 2192-2197, ISSN: 0161-6420
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- Citations: 156
Mead AL, Wong TTL, Cordeiro MF, et al., 2003, Evaluation of anti-TGF-<i>β</i>2 antibody as a new postoperative anti-scarring agent in glaucoma surgery, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 44, Pages: 3394-3401, ISSN: 0146-0404
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- Citations: 185
Cordeiro MF, 2003, Technology evaluation: Lerdelimumab, Cambridge Antibody Technology, CURRENT OPINION IN MOLECULAR THERAPEUTICS, Vol: 5, Pages: 199-203, ISSN: 1464-8431
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- Citations: 11
Cordeiro MF, 2003, Transforming growth factor-β function blocking already effective as therapeutic strategy, CIRCULATION, Vol: 107, Pages: E37-E37, ISSN: 0009-7322
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- Citations: 3
CORDEIRO MF, 2003, Role of transforming growth factor β in conjunctival scarring, Clinical Science, Vol: 104, Pages: 181-181, ISSN: 0143-5221
Cordeiro MF, 2003, Role of transforming growth factor β in conjunctival scarring, Meeting of the Medical-Research-Society, Publisher: PORTLAND PRESS, Pages: 181-187, ISSN: 0143-5221
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- Citations: 52
Cordeiro MF, Mead A, Ali RR, et al., 2003, Novel antisense oligonucleotides targeting TGF-β inhibit in vivo scarring and improve surgical outcome, GENE THERAPY, Vol: 10, Pages: 59-71, ISSN: 0969-7128
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- Citations: 147
Siriwardena D, Khaw PT, King AJ, et al., 2002, Human antitransforming growth factor β<sub>2</sub> monoclonal antibody -: A new modulator of wound healing in trabeculectomy -: A randomized placebo controlled clinical study, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ELSEVIER SCIENCE INC, Pages: 427-431, ISSN: 0161-6420
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- Citations: 107
Cordeiro MF, 2002, Beyond mitomycin:: TGF-β and wound healing, PROGRESS IN RETINAL AND EYE RESEARCH, Vol: 21, Pages: 75-89, ISSN: 1350-9462
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- Citations: 63
Khaw PT, Chang L, Wong TTL, et al., 2001, Erratum: Modulation of wound healing after glaucoma surgery (Current Opinion in Opthalmology (2001) 12 (143-156)), Current Opinion in Ophthalmology, Vol: 12, ISSN: 1040-8738
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- Citations: 1
Khaw PT, Chang L, Wong TTL, et al., 2001, Modulation of wound healing after glaucoma surgery, CURRENT OPINION IN OPHTHALMOLOGY, Vol: 12, Pages: 143-148, ISSN: 1040-8738
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- Citations: 93
Chang L, Crowston JG, Cordeiro MF, et al., 2000, The role of the immune system in conjunctival wound healing after glaucoma surgery, SURVEY OF OPHTHALMOLOGY, Vol: 45, Pages: 49-68, ISSN: 0039-6257
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- Citations: 96
Cordeiro MF, Chang L, Lim KS, et al., 2000, Modulating conjunctival wound healing, Cambridge Symposium on Glaucoma, Publisher: NATURE PUBLISHING GROUP, Pages: 536-547, ISSN: 0950-222X
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- Citations: 67
Cordeiro MF, Siriwardena D, Chang L, et al., 2000, Wound healing modulation after glaucoma surgery., Curr Opin Ophthalmol, Vol: 11, Pages: 121-126, ISSN: 1040-8738
Recent developments in molecular and cell biology have made a major impact on our understanding of the wound healing process and its modification. In this article, the spectrum of therapies that are either currently available or have potential application as modulators of the scarring response following glaucoma surgery are reviewed. Refinement of existing antimetabolite regimens can improve surgical results, especially in carefully selected patient groups. However, the most promising new approach appears to be using molecular-based therapies, such as fully human neutralizing monoclonal antibodies, designed to target specific molecules in the scarring response. Such strategies ultimately offer the potential of safer, more specific, focal, and titratable treatment, with far-reaching clinical applications.
Cordeiro MF, Bhattacharya SS, Schultz GS, et al., 2000, TGF-β1, -β2, and -β3 in vitro:: Biphasic effects on Tenon's fibroblast contraction, proliferation, and migration, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 41, Pages: 756-763, ISSN: 0146-0404
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- Citations: 147
Cordeiro MF, Bhattacharya SS, Schultz GS, et al., 2000, TGF-beta1, -beta2, and -beta3 in vitro: biphasic effects on Tenon's fibroblast contraction, proliferation, and migration., Invest Ophthalmol Vis Sci, Vol: 41, Pages: 756-763, ISSN: 0146-0404
PURPOSE: To compare the effects of the three human transforming growth factor-beta (TGF-beta) isoforms and different concentrations of TGF-beta on human Tenon's capsule fibroblasts (HTF), with a view to delineating the role of this growth factor in the subconjunctival scarring response after glaucoma filtration surgery. METHODS: Application of recombinant human TGF-beta1, -beta2, and -beta3 (range 0-10(-8) M) was assessed using several assays of HTF function: fibroblast-mediated collagen contraction, proliferation, and migration. RESULTS: All three isoforms of TGF-beta behaved in a similar manner in vitro. They each stimulated HTF-mediated collagen contraction, proliferation, and migration with a characteristic concentration-dependent response, with peak activities at 10(-9), 10(-12), and 10(-9) M, respectively, that were significantly different from control (P<0.05). At concentrations above and below peak activities, HTF activity was reduced, demonstrating biphasic effects of TGF-beta. CONCLUSIONS: TGF-beta1, -beta2, and -beta3 have similar actions in vitro; this is demonstrated by their effects on several HTF-mediated functions. TGF-beta induces a response in HTF that is concentration-dependent, with different functions being maximally stimulated at different concentrations. This biphasic response highlights the significance of the concentration profile of TGF-beta at the wound site. These findings are important in filtration surgery, where constant changes in the local environment occur due to the passage of aqueous and the wound healing process. The varying levels of TGF-beta in the aqueous and subconjunctival tissues may thus significantly modify the conjunctival scarring response.
Cordeiro MF, Chang L, Khaw PT, 2000, The healing of ocular tissues: The basis of successful treatment of ocular disease, Ophthalmology Clinics of North America, Vol: 13, Pages: 101-110, ISSN: 0896-1549
The processes regulating ocular scarring are numerous and complex, with modulation being now possible at virtually every stage of the healing response. This article reviews existing and potential therapies that modify the scarring response with particular reference to glaucoma filtration surgery. Although the introduction of the antiproliferative drugs mitomycin-C (MMC) and 5-fluorouracil (5-FU) represents a major advance in antiscarring treatments, they are associated with significant complications. It is only with increasing knowledge of the mechanisms underlying the scarring process that refinement and development of such therapies can be achieved. As we move into the next millennium, new techniques and technologies in molecular therapy and cell biology provide exciting alternative strategies that may offer safer, more specific, focal, and titratable treatments with far- reaching clinical applications.
Cordeiro MF, Schultz GS, Ali RR, et al., 1999, Molecular therapy in ocular wound healing, BRITISH JOURNAL OF OPHTHALMOLOGY, Vol: 83, Pages: 1219-1224, ISSN: 0007-1161
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- Citations: 31
Cordeiro MF, Plant GT, Child A, et al., 1999, Visual loss after primary trabeculectomy with mitomycin C in Ehlers-Danlos syndrome, BRITISH JOURNAL OF OPHTHALMOLOGY, Vol: 83, Pages: 1202-1204, ISSN: 0007-1161
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- Citations: 1
Cordeiro MF, Gay JA, Khaw PT, 1999, Human anti-transforming growth factor-β2 antibody:: A new glaucoma anti-scarring agent, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 40, Pages: 2225-2234, ISSN: 0146-0404
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- Citations: 170
Cordeiro MF, Reichel MB, Gay JA, et al., 1999, Transforming growth factor-β1, -β2, and -β3 in vivo:: Effects on normal and mitomycin C-modulated conjunctival scarring, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 40, Pages: 1975-1982, ISSN: 0146-0404
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- Citations: 87
Cordeiro MF, Khaw PT, 1999, The healing optic nerve in glaucoma:: transforming growth factor β and optic nerve head remodelling, BRITISH JOURNAL OF OPHTHALMOLOGY, Vol: 83, Pages: 132-133, ISSN: 0007-1161
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- Citations: 7
Daniels JT, Occleston NL, Crowston JG, et al., 1998, Understanding and controlling the scarring response: The contribution of histology and microscopy, Microscopy Research and Technique, Vol: 42, Pages: 317-333, ISSN: 1059-910X
In response to injury, the body usually initiates a full and swift wound healing response resulting in reconstructed, repaired tissue. In certain instances, due to a variety of factors, this may not happen, an example being chronic granulating venous leg ulcers. At the other extreme, the wound may heal excessively, producing disabling hypertrophic scarring such as can occur following large, deep burn injuries. Our group is interested in the surgical treatment of the eye disease glaucoma. As will be explained, the successful surgical treatment of this disease depends on a reduced scarring response at the end of wound healing. The purpose of this article is to give an overview of our microscopic and histological experimental work which has furthered our understanding of tissue repair, particularly the scarring response and its potential modification for successful glaucoma surgery.
Daniels JT, Occleston NL, Crowston JG, et al., 1998, Understanding and controlling the scarring response: The contribution of histology and microscopy, MICROSCOPY RESEARCH AND TECHNIQUE, Vol: 42, Pages: 317-333, ISSN: 1059-910X
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- Citations: 21
Reichel MB, Cordeiro MF, Alexander RA, et al., 1998, New model of conjunctival scarring in the mouse eye, BRITISH JOURNAL OF OPHTHALMOLOGY, Vol: 82, Pages: 1072-1077, ISSN: 0007-1161
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- Citations: 34
Constable PH, Crowston JG, Occleston NL, et al., 1998, Long term growth arrest of human Tenon's fibroblasts following single applications of β radiation, BRITISH JOURNAL OF OPHTHALMOLOGY, Vol: 82, Pages: 448-452, ISSN: 0007-1161
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- Citations: 19
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