Imperial College London
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Professor M Francesca Cordeiro

Faculty of Medicine, Department of Surgery & Cancer

Chair in Ophthalmology (Clinical)
 
 
 
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Contact

 

m.cordeiro

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Davis:2017:10.1016/j.mito.2017.05.010,
author = {Davis, BM and Tian, K and Pahlitzsch, M and Brenton, J and Ravindran, N and Butt, G and Malaguarnera, G and Normando, EM and Guo, L and Cordeiro, MF},
doi = {10.1016/j.mito.2017.05.010},
journal = {Mitochondrion},
pages = {114--123},
title = {Topical coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension},
url = {http://dx.doi.org/10.1016/j.mito.2017.05.010},
volume = {36},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Coenzyme Q10 (CoQ10) is a mitochondrial-targeted antioxidant with known neuroprotective activity. Its ocular effects when co-solubilised with α–tocopherol polyethylene glycol succinate (TPGS) were evaluated. In vitro studies confirmed that CoQ10 was significantly protective in different retinal ganglion cell (RGC) models. In vivo studies in Adult Dark Agouti (DA) rats with unilateral surgically-induced ocular hypertension (OHT) treated with either CoQ10/TPGS micelles or TPGS vehicle twice daily for three weeks were performed, following which retinal cell health was assessed in vivo using DARC (Detection of Apoptotic Retinal Cells) and post-mortem with Brn3a histological assessment on whole retinal mounts. CoQ10/TPGS showed a significant neuroprotective effect compared to control with DARC (p < 0.05) and Brn3 (p < 0.01). Topical CoQ10 appears an effective therapy preventing RGC apoptosis and loss in glaucoma-related models.
AU  - Davis,BM
AU  - Tian,K
AU  - Pahlitzsch,M
AU  - Brenton,J
AU  - Ravindran,N
AU  - Butt,G
AU  - Malaguarnera,G
AU  - Normando,EM
AU  - Guo,L
AU  - Cordeiro,MF
DO  - 10.1016/j.mito.2017.05.010
EP  - 123
PY  - 2017///
SN  - 1567-7249
SP  - 114
TI  - Topical coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension
T2  - Mitochondrion
UR  - http://dx.doi.org/10.1016/j.mito.2017.05.010
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000413888000016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/63307
VL  - 36
ER  -
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