Publications
710 results found
Wells KD, Ferguson MJ, McDonald R, et al., 2011, Ethylene Substitution in a Bis-Ethylene Complex of Rh/Os and Unusual Bronsted-Lowry Basicity of an N-Heterocyclic Carbene, ORGANOMETALLICS, Vol: 30, Pages: 815-825, ISSN: 0276-7333
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- Citations: 9
Ward NR, Roldao V, Cowie MR, et al., 2011, Utility Of Pulse Oximetry Versus Heart Rate Variability To Screen For Sleep-Disordered Breathing In Chronic Heart Failure, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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- Citations: 1
Mobarok MH, Oke O, Ferguson MJ, et al., 2010, Multiple Silicon-Hydrogen Bond Activations at Adjacent Rhodium and Iridium Centers, INORGANIC CHEMISTRY, Vol: 49, Pages: 11556-11572, ISSN: 0020-1669
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- Citations: 13
O'Hanlon R, Grasso A, Roughton M, et al., 2010, Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy using cardiovascular magnetic resonance, Journal of Cardiovascular Magnetic Resonance, Vol: 12, ISSN: 1097-6647
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- Citations: 2
Ward NR, Cowie MR, Rosen SD, et al., 2010, DETECTION OF SLEEP-DISORDERED BREATHING IN CHRONIC HEART FAILURE PATIENTS: UTILITY OF HEART RATE VARIABILITY VERSUS PULSE OXIMETRY?, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A10-A11, ISSN: 0040-6376
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- Citations: 1
Slaney ME, Anderson DJ, Ferguson MJ, et al., 2010, The Bridged Binding Mode as a New, Versatile Template for the Selective Activation of Carbon-Fluorine Bonds in Fluoroolefins: Activation of Trifluoroethylene, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 132, Pages: 16544-16558, ISSN: 0002-7863
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- Citations: 28
Whalley G, Poppe K, Earle N, et al., 2010, The Impact of LV Dilatation on Mortality in Heart Failure with Preserved Ejection Fraction: Implications for Current Heart Failure Guidelines, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Hobbs FDR, Doust J, Mant J, et al., 2010, Diagnosis of heart failure in primary care, HEART, Vol: 96, Pages: 1773-1777, ISSN: 1355-6037
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- Citations: 22
Cowie MR, 2010, Improving the management of chronic heart failure., Practitioner, Vol: 254, Pages: 29-3, ISSN: 0032-6518
NICE has updated its guideline on heart failure. The principal changes from the 2003 guideline include more directive advice on how to improve the quality and timeliness of diagnosis. There is greater encouragement to use beta-blockers, more emphasis on rehabilitation, and better access to specialist advice--particularly at the time of diagnosis, admission to hospital, and where symptoms do not respond to first-line therapy with diuretics, ACE inhibitors and beta-blockers. A full history should be taken and clinical examination carried out. Patients with a past history of MI, or those with a high plasma BNP, should be referred to be seen within two weeks for echocardiography and specialist opinion. The specialist should determine: whether heart failure is present; its likely aetiology; precipitating factors; type of cardiac dysfunction; correctable causes; relevant comorbidity, and prognosis. Those with no history of MI but an elevated plasma BNP should be referred to be seen within six weeks for such assessment. Older adults, and patients with peripheral vascular disease, erectile dysfunction, diabetes mellitus, interstitial pulmonary disease and COPD without reversibility should be considered for beta-blocker therapy. A start low, go slow approach is recommended, with clinical review after each titration. Monitoring should include a clinical assessment, medication review, and a check of renal function as a minimum. Such a review should take place at least six monthly but may have to be much more frequent if there is a change in drug prescription or clinical status. Patients with stable heart failure should be offered a supervised group exercise-based rehabilitation programme designed for such patients. This should include a psychological and educational component, and could be incorporated within an existing cardiac rehabilitation programme.
O'Hanlon R, Grasso A, Roughton M, et al., 2010, Prognostic Significance of Myocardial Fibrosis in Hypertrophic Cardiomyopathy, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 56, Pages: 867-874, ISSN: 0735-1097
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- Citations: 599
Haydock PM, Cowie MR, 2010, Heart failure: classification and pathophysiology, Medicine (United Kingdom), Vol: 38, Pages: 467-472, ISSN: 1357-3039
Heart failure (HF) is a clinical syndrome and not a stand-alone diagnosis – identification of the aetiology of the underlying cardiac abnormality and the whole body's response to it is key to providing optimal management of the individual patient. The classic triad of clinical features – breathlessness, fatigue and fluid retention – can be the result of any disorder (genetic or acquired) affecting the structure or function of the heart in a manner that impairs its ability to act as an efficient pump. Despite improved understanding of the pathophysiology, and a wider range of therapeutic options, HF remains a serious condition with considerable morbidity and mortality. It is a global problem, though the relative importance of different aetiologies differs between the developed world – where the syndrome is most commonly a consequence of ischaemic heart disease – and the developing world, where rheumatic fever remains an important cause. HF can present either de novo, as a consequence of acute myocardial insult, or in its chronic form, where decompensation secondary to coincident medical problems often requires acute management. The HF syndrome is characterized by cardiac dysfunction with haemodynamic, renal and neurohormonal changes attempting to maintain circulatory homeostasis. Ultimately, such changes are maladaptive and result in excessive sodium and fluid retention, changes in muscle blood flow, altered breathing pattern, arrhythmia, and an inflammatory state with immune activation. Current evidence-based therapies ameliorate these responses and improve survival and quality of life.
Shafe A, Lee S, Cowie M, 2010, EARTH-Epidemiology of AtheRosclerotic Disease in THe UK: Evidence of Reducing Incidence of Cardiovascular Disease (CVD), Particularly Coronary Heart Disease, in the UK Adult Population between 1999 and 2008, PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Vol: 19, Pages: S30-S30, ISSN: 1053-8569
Cowie MR, 2010, Response to Editorial: Pitfalls in economic analysis, EUROPACE, Vol: 12, Pages: 1044-1046, ISSN: 1099-5129
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- Citations: 1
Hounjel LJ, Bierenstiel M, Ferguson MJ, et al., 2010, Coordinatively Diverse <i>ortho</i>-Phosphinoaniline Complexes of Ruthenium and Isolation of a Putative Intermediate in Ketone Transfer Hydrogenation Catalysis, INORGANIC CHEMISTRY, Vol: 49, Pages: 4288-4300, ISSN: 0020-1669
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- Citations: 22
Cowie M, 2010, British Journal of Cardiology: Introduction, British Journal of Cardiology, Vol: 17, ISSN: 0969-6113
Vazir A, Morrell M, Simonds AK, et al., 2010, Author reply to the letter by Girerd and colleagues titled: "Sleep apnea in patients with heart failure: could cardiac resynchronisation therapy be first line treatment?" IJC-D-08-02655, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 140, Pages: 130-131, ISSN: 0167-5273
Cowie M, Slaney ME, Anderson J, et al., 2010, Carbon-fluorine bond activation in fluoroolefins promoted by adjacent metals, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
Cowie MR, Collinson PO, Dargie H, et al., 2010, Recommendations on the clinical use of B-type natriuretic peptide testing (BNP or NTproBNP) in the UK and Ireland, British Journal of Cardiology, Vol: 17, Pages: 76-80, ISSN: 0969-6113
Plasma natriuretic peptide (NP) testing is not widely used in heart failure clinical practice in the UK or Ireland, despite a large evidence base. This article reports the views of a consensus group that was set up to develop guidance on the place of NP testing for clinicians in primary and secondary care. There is firm evidence for NP testing as part of the heart failure diagnostic pathway. Measuring NPs is also a useful prognostic tool and can help with discharge planning, and there is emerging evidence for use in treatment monitoring particularly in younger patients. For the future, NP measurement might also prove to be useful for screening high-risk patients for asymptomatic left ventricular systolic dysfunction. Copyright Medinews (Cardiology) Limited Reproduction Prohibited.
Hastings PC, Vazir A, Meadows GE, et al., 2010, Adaptive servo-ventilation in heart failure patients with sleep apnea: A real world study, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 139, Pages: 17-24, ISSN: 0167-5273
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- Citations: 80
Vazir A, Hastings PC, Morrell MJ, et al., 2010, Resolution of central sleep apnoea following implantation of a left ventricular assist device, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 138, Pages: 317-319, ISSN: 0167-5273
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- Citations: 22
Cowie MR, 2010, "Hospital at home" care shows similar mortality and subsequent hospital admissions to hospital care for older patients with acutely decompensated chronic heart failure, Evidence-Based Medicine, Vol: 15, Pages: 9-10, ISSN: 1356-5524
Cowie MR, 2010, "Hospital at home" care shows similar mortality and subsequent hospital admissions to hospital care for older patients with acutely decompensated chronic heart failure., Evid Based Med, Vol: 15, Pages: 9-10
Cowie MR, Haydock PM, 2010, Pathophysiology and modern management of cardiac failure, Non-invasive Ventilation and Weaning: Principles and Practice, Pages: 277-288, ISBN: 9780340941522
Cardiac failure is a clinical syndrome comprising a triad of breathlessness, fatigue and fluid retention. These symptoms can be the result of any disorder, genetic or acquired, affecting the structure or function of the heart in a manner that impairs its ability to act as an efficient pump. Heart failure is not a stand-alone diagnosis – identification of the aetiology and how the body has responded to the cardiac dysfunction is key to providing optimal management of the individual patient. The syndrome can develop relatively suddenly (acute de-novo heart failure), or can be present for many months or years (chronic heart failure). Acute decompensation of the chronic syndrome is not infrequent, particularly where compliance with treatment is poor, monitoring is sub-standard, or with intercurrent illness. The syndrome is characterized by cardiac dysfunction, consequent haemodynamic changes attempting to maintain circulatory homeostasis, changes in breathing pattern, sodium and fluid retention through renal and neurohormonal mechanisms, changes in muscle blood flow, and immune activation. In suspected heart failure, the physician should remember that identification of the syndrome is based on history and examination combined with appropriate investigations; a normal resting electrocardiogram should raise doubt regarding the validity of the diagnosis; plasma natriuretic peptide levels can help to establish the diagnosis; and echocardiography should be used to image the heart for quantifiable determination of cardiac structure and function. Where heart failure is confirmed, management consists of lifestyle measures and the introduction and optimization of medications such as diuretics, inhibitors of the renin–angiotensin–aldosterone axis, and selected β-blockers. For patients fulfilling certain criteria, implantable defibrillators or cardiac resynchronization therapy can also decrease mortality and, in the latter case, improve symptoms. Despite imp
Carrio I, Cowie MR, Yamazaki J, et al., 2010, Cardiac Sympathetic Imaging With <i>m</i>IBG in Heart Failure, JACC-CARDIOVASCULAR IMAGING, Vol: 3, Pages: 92-100, ISSN: 1936-878X
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- Citations: 145
Teschler H, Cowie MR, d'Ortho M-P, et al., 2010, Rationale and Design of the SERVE HF study: Treatment of Sleep-disordered Breathing with Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients with Heart Failure, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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- Citations: 4
Ward NR, Roldao V, Rosen SD, et al., 2010, How Often Do Mixed Apneas Occur In Chronic Heart Failure Patients and What Is Their Impact On Diagnosis Of Sleep-Disordered Breathing?, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Cowie MR, Chandrasekaran B, 2009, Cardiac Failure, Oxford Textbook of Medicine, Editors: Warrell, Cox, Firth, Publisher: Oxford Univ Pr, ISBN: 9780199204854
Riley JP, Cowie MR, 2009, Telemonitoring in heart failure, HEART, Vol: 95, Pages: 1964-1968, ISSN: 1355-6037
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- Citations: 23
Mehta PA, Dubrey SW, McIntyre HF, et al., 2009, Improving survival in the 6 months after diagnosis of heart failure in the past decade: population-based data from the UK, HEART, Vol: 95, Pages: 1851-1856, ISSN: 1355-6037
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- Citations: 47
Cowie MR, Haydock PM, 2009, Cardiac failure, Non-Invasive Ventilation and Weaning: Principles and Practice, Editors: Elliott, Nava, Schonhofer, London, UK, Publisher: Hodder Arnold, Pages: 277-288, ISBN: 9780340941522
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