Imperial College London

ProfessorMichaelSchneider

Faculty of MedicineNational Heart & Lung Institute

Chair in Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 3027m.d.schneider Website

 
 
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Assistant

 

Miss Cassie Tarquini +44 (0)20 7594 3020

 
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Location

 

336ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

167 results found

Shim J-H, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LHet al., 2009, TAK1 is an essential regulator of BMP signalling in cartilage, EMBO JOURNAL, Vol: 28, Pages: 2028-2041, ISSN: 0261-4189

Journal article

Noseda M, Schneider MD, 2009, Fibroblasts inform the heart: Control of cardiomyocyte cycling and size by age-dependent paracrine signals, DEV CELL, Vol: 16, Pages: 161-162, ISSN: 1534-5807

Within the developing and adult heart, the fibroblast is often dismissed as merely a structural element, important just to mechanical integrity or to scarring when excessive in disease. leda et al. in this issue of Developmental Cell now report an essential program of paracrine factor production in cardiac fibroblasts that controls heart muscle cell growth, driving cycling or enlargement depending on the fibroblasts' developmental stage.

Journal article

Yu Y, Ge N, Xie M, Sun W, Burlingame S, Pass AK, Nuchtern JG, Zhang D, Fu S, Schneider MD, Fan J, Yang Jet al., 2008, Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop Is Required for Interleukin (IL)-1-mediated Optimal NF kappa B and AP-1 Activation as Well as IL-6 Gene Expression, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 24497-24505, ISSN: 0021-9258

Journal article

Chen J-F, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang D-Zet al., 2008, Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 105, Pages: 2111-2116, ISSN: 0027-8424

Journal article

Stroud DM, Gaussin V, Burch JBE, Yu C, Mishina Y, Schneider MD, Fishman GI, Morley GEet al., 2007, Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor., Circulation, Vol: 116, Pages: 2535-2543

BACKGROUND: The atrioventricular (AV) node is essential for the sequential excitation and optimized contraction of the adult multichambered heart; however, relatively little is known about its formation from the embryonic AV canal. A recent study demonstrated that signaling by Alk3, the type 1a receptor for bone morphogenetic proteins, in the myocardium of the AV canal was required for the development of both the AV valves and annulus fibrosus. To test the hypothesis that bone morphogenetic protein signaling also plays a role in AV node formation, we investigated conduction system function and AV node morphology in adult mice with conditional deletion of Alk3 in the AV canal. METHODS AND RESULTS: High-resolution optical mapping with correlative histological analysis of 28 mutant hearts revealed 4 basic phenotypic classes based on electrical activation patterns and volume-conducted ECGs. The frequency of AV node conduction and morphological abnormalities increased from no detectable anomalies (class I) to severe defects (class IV), which included the presence of bypass tracts, abnormal ventricular activation patterns, fibrosis of the AV node, and twin AV nodes. CONCLUSIONS: The present findings demonstrate that bone morphogenetic protein signaling is required in the myocardium of the AV canal for proper AV junction development, including the AV node.

Journal article

Stroud DM, Gaussin V, Burch JBE, Yu C, Mishina Y, Schneider MD, Fishman GI, Morley GEet al., 2007, Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal-targeted deletion of Alk3/Bmpr1a receptor, CIRCULATION, Vol: 116, Pages: 2535-2543, ISSN: 0009-7322

Journal article

Ding G, Fu M, Qin Q, Lewis W, Kim HW, Fukai T, Bacanamwo M, Chen YE, Schneider MD, Mangelsdorf DJ, Evans RM, Yang Qet al., 2007, Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage, CARDIOVASCULAR RESEARCH, Vol: 76, Pages: 269-279, ISSN: 0008-6363

Journal article

Haudek SB, Taffet GE, Schneider MD, Mann DLet al., 2007, TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways, JOURNAL OF CLINICAL INVESTIGATION, Vol: 117, Pages: 2692-2701, ISSN: 0021-9738

Journal article

Qu J, Zhou J, Yi XP, Dong B, Zheng H, Miller LM, Wang X, Schneider MD, Li Fet al., 2007, Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 43, Pages: 319-326, ISSN: 0022-2828

Journal article

Chang GY, Cao F, Krishnan M, Huang M, Li Z, Xie X, Sheikh AY, Hoyt G, Robbins RC, Hsial T, Schneider MD, Wu JCet al., 2007, Positron emission tomography imaging of conditional gene activation in the heart, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 43, Pages: 18-26, ISSN: 0022-2828

Journal article

Matus M, Lewin G, Stuempel F, Buchwalow IB, Schneider MD, Schuetz G, Schmitz W, Mueller FUet al., 2007, Cardiomyocyte-specific inactivation of transcription factor CREB in mice, FASEB JOURNAL, Vol: 21, Pages: 1884-1892, ISSN: 0892-6638

Journal article

Liu Y, Asakura M, Inoue H, Nakamura T, Sano M, Niu Z, Chen M, Schwartz RJ, Schneider MDet al., 2007, Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 3859-3864, ISSN: 0027-8424

Journal article

Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand J-L, Desjardins F, Ansari A, Struman I, Nguyen NQN, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler Het al., 2007, A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy, CELL, Vol: 128, Pages: 589-600, ISSN: 0092-8674

Journal article

Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Makela TP, Schneider MDet al., 2007, Menage-a-trois 1 is critical for the transcriptional function of PPAR gamma coactivator 1, CELL METABOLISM, Vol: 5, Pages: 129-142, ISSN: 1550-4131

Journal article

Eckardt D, Kirchhoff S, Kim J-S, Degen J, Theis M, Ott T, Wiesmann F, Doevendans PA, Lamers WH, de Bakker JMT, van Rijen HVM, Schneider MD, Willecke Ket al., 2006, Cardiomyocyte-restricted deletion of Connexin43 during mouse development, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 41, Pages: 963-971, ISSN: 0022-2828

Journal article

Xie M, Zhang D, Dyck JRB, Li Y, Zhang H, Morishima M, Mann DL, Taffet GE, Baldini A, Khoury DS, Schneider MDet al., 2006, A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 17378-17383, ISSN: 0027-8424

Journal article

Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJet al., 2006, Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 14495-14500, ISSN: 0027-8424

Journal article

Mysliwiec MR, Chen J, Powers PA, Bartley CR, Schneider MD, Lee Yet al., 2006, Generation of a conditional null allele of jumonji, GENESIS, Vol: 44, Pages: 407-411, ISSN: 1526-954X

Journal article

Liu H-H, Xie M, Schneider MD, Chen ZJet al., 2006, Essential role of TAK1 in thymocyte development and activation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 11677-11682, ISSN: 0027-8424

Journal article

Wan YY, Chi H, Xie M, Schneider MD, Flavell RAet al., 2006, The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function, NATURE IMMUNOLOGY, Vol: 7, Pages: 851-858, ISSN: 1529-2908

Journal article

van Oort RJ, van Rooij E, Bourajjaj M, Schimmel J, Jansen MA, van der Nagel R, Doevendans PA, Schneider MD, van Echteld CJA, De Windt LJet al., 2006, MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failure, CIRCULATION, Vol: 114, Pages: 298-308, ISSN: 0009-7322

Journal article

Garcia-Gras E, Lombardi R, Giocondo MJ, Willerson JT, Schneider MD, Khoury DS, Marian AJet al., 2006, Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy, JOURNAL OF CLINICAL INVESTIGATION, Vol: 116, Pages: 2012-2021, ISSN: 0021-9738

Journal article

Schwartz RJ, Schneider MD, 2006, CAMTA in cardiac hypertrophy, CELL, Vol: 125, Pages: 427-429, ISSN: 0092-8674

Journal article

Zhang Y-M, Bo J, Taffet GE, Chang J, Shi J, Reddy AK, Michael LH, Schneider MD, Entman ML, Schwartz RJ, Wei Let al., 2006, Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis, FASEB JOURNAL, Vol: 20, Pages: 916-925, ISSN: 0892-6638

Journal article

Chen JW, Zhou B, Yu QC, Shin SJ, Jiao K, Schneider MD, Baldwin HS, Bergelson JMet al., 2006, Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves, CIRCULATION RESEARCH, Vol: 98, Pages: 923-930, ISSN: 0009-7330

Journal article

Wang JK, Sridurongrit S, Dudas M, Thomas P, Nagy A, Schneider MD, Epstein JA, Kaartinen Vet al., 2005, Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart, DEVELOPMENTAL BIOLOGY, Vol: 286, Pages: 299-310, ISSN: 0012-1606

Journal article

Pattingre S, Tassa A, Qu XP, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine Bet al., 2005, Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy, CELL, Vol: 122, Pages: 927-939, ISSN: 0092-8674

Journal article

Gaussin V, Morley GE, Cox L, Zwijsen A, Vance KM, Emile L, Tian YM, Liu J, Hong C, Myers D, Conway SJ, Depre C, Mishina Y, Behringer RR, Hanks MC, Schneider MD, Huylebroeck D, Fishman GI, Burch JBE, Vatner SFet al., 2005, Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus, CIRCULATION RESEARCH, Vol: 97, Pages: 219-226, ISSN: 0009-7330

Journal article

Schneider MD, 2005, Cyclophilin D: knocking on death's door., Sci STKE, Vol: 2005

Two recent genetic studies have identified a critical role for cyclophilin D, a component of the mitochondrial membrane permeability transition pore, in cell death induced by calcium, reactive oxygen species, and cardiac ischemia-reperfusion injury. Transgenic mice lacking cyclophilin D developed normally but showed reduced infarct size after coronary artery ligation and reperfusion. Cells from the knockout mice were resistant to death imposed by excess calcium and H2O2, but not to death from x-irradiation, staurosporine, tumor necrosis factor-alpha, or forced expression of proapoptotic proteins. These data raise questions about the relationship between apoptotic and necrotic cell death, and they also highlight cyclophilin D as a potential therapeutic target in myocardial infarction.

Journal article

Sano M, Schneider MD, 2005, Energizer: PGC-1 alpha keeps the heart going, CELL METABOLISM, Vol: 1, Pages: 216-218, ISSN: 1550-4131

Journal article

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