Imperial College London

ProfessorMichaelSchneider

Faculty of MedicineNational Heart & Lung Institute

Chair in Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 3027m.d.schneider Website

 
 
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Assistant

 

Miss Cassie Tarquini +44 (0)20 7594 3020

 
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Location

 

336ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

167 results found

Benjamin IJ, Schneider MD, 2005, Learning from failure: congestive heart failure in the postgenomic age, JOURNAL OF CLINICAL INVESTIGATION, Vol: 115, Pages: 495-499, ISSN: 0021-9738

Journal article

MacLellan WR, Garcia A, Oh H, Frenkel P, Jordan MC, Roos KP, Schneider MDet al., 2005, Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb, MOLECULAR AND CELLULAR BIOLOGY, Vol: 25, Pages: 2486-2497, ISSN: 0270-7306

Journal article

Dimmeler S, Zeiher AM, Schneider MD, 2005, Unchain my heart: the scientific foundations of cardiac repair, JOURNAL OF CLINICAL INVESTIGATION, Vol: 115, Pages: 572-583, ISSN: 0021-9738

Journal article

McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson ENet al., 2005, The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner, DEVELOPMENT, Vol: 132, Pages: 189-201, ISSN: 0950-1991

Journal article

Spyridopoulos I, Haendeler J, Urbich C, Brummendorf TH, Oh H, Schneider MD, Zeiher AM, Dimmeler Set al., 2004, Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells, CIRCULATION, Vol: 110, Pages: 3136-3142, ISSN: 0009-7322

Journal article

Cheng LH, Ding GL, Qin QH, Huang Y, Lewis W, He N, Evans RM, Schneider MD, Brako FA, Xiao Y, Chen YQE, Yang QLet al., 2004, Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy, NATURE MEDICINE, Vol: 10, Pages: 1245-1250, ISSN: 1078-8956

Journal article

Sano M, Schneider MD, 2004, Cyclin-dependent kinase-9 - An RNAPII kinase at the nexus of cardiac growth and death cascades, CIRCULATION RESEARCH, Vol: 95, Pages: 867-876, ISSN: 0009-7330

Journal article

Imahashi K, Schneider MD, Steenbergen C, Murphy Eet al., 2004, Transgenic expression of Bcl-2 modulates energy metabolism, prevents cytosolic acidification during ischemia, and reduces ischemia/reperfusion injury, CIRCULATION RESEARCH, Vol: 95, Pages: 734-741, ISSN: 0009-7330

Journal article

de Lange FJ, Moorman AFM, Anderson RH, Manner J, Soufan AT, de Vries CD, Schneider MD, Webb S, van den Hoff MJB, Christoffels VMet al., 2004, Lineage and morphogenetic analysis of the cardiac valves, CIRCULATION RESEARCH, Vol: 95, Pages: 645-654, ISSN: 0009-7330

Journal article

Sano M, Wang SC, Shirai M, Scaglia F, Xie M, Sakai S, Tanaka T, Kulkarni PA, Barger PM, Youker KA, Taffet GE, Hamamori Y, Michael LH, Craigen WJ, Schneider MDet al., 2004, Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure, EMBO JOURNAL, Vol: 23, Pages: 3559-3569, ISSN: 0261-4189

Journal article

Hilfiker-Kleiner D, Hilfiker A, Fuchs M, Kaminski K, Schaefer A, Schieffer B, Hillmer A, Schmiedl A, Ding ZP, Podewski E, Podewski E, Poli V, Schneider MD, Schulz R, Park JK, Wollert KC, Drexler Het al., 2004, Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury, CIRCULATION RESEARCH, Vol: 95, Pages: 187-195, ISSN: 0009-7330

Journal article

Chen HY, Shi S, Acosta L, Li WM, Lu J, Bao SD, Chen ZA, Yang ZC, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou WNet al., 2004, BMP10 is essential for maintaining cardiac growth during murine cardiogenesis, DEVELOPMENT, Vol: 131, Pages: 2219-2231, ISSN: 0950-1991

Journal article

Oh H, Chi X, Bradfute SB, Mishina Y, Pocius J, Michael LH, Behringer RR, Schwartz RJ, Entman ML, Schneider MDet al., 2004, Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells., Ann N Y Acad Sci, Vol: 1015, Pages: 182-189, ISSN: 0077-8923

The evidence of cardiomyocyte proliferation in damaged heart implied cardiac regeneration might occur by resident or extra cardiac stem cells. However, the specification and origin of these cells remain unknown. Here, we report using fluorescence-activated cell sorting that cardiac progenitor cells resided in adult heart and colocalized with small capillary vessels, within the stem cell antigen (Sca-1) population expressing high telomerase activity. Notably, hematopoietic stem cells capable of efflux Hoechst 33342, termed side population cells, also were identified within the heart-derived cells. The cardiac progenitor cells (CD45(-)/CD34(-)) express neither cardiac muscle nor endothelial cell markers at an undifferentiated stage. The exposure of 5-azacytidine induced cardiac differentiation, which depends, in part, on Bmpr1a, a type IA receptor for bone morphogenetic protein (BMP). The capability of adult Sca1(+) cells to adopt a cardiac muscle in embryogenesis was substantiated by blastocyst injection, using progenitors from the adult hearts of transgenic mice that harbor a bacterial artificial chromosome expressing GFP via the Nkx-2.5 locus. Intravenously injected progenitors, shortly after ischemic/reperfusion, homed and functionally differentiated 3.5% of total left ventricle in the host myocardium. Differentiation included both fusion-independent and fusion-associated components, proved by the Cre/loxP donor/recipient system. Our studies suggest that endogenous cardiac progenitors reside in the adult heart, regenerate cardiomyocytes functionally, and integrate into the existing heart circuitry.

Journal article

Bruhl T, Heeschen C, Aicher A, Jadidi AS, Haendeler J, Hoffmann J, Schneider MD, Zeiher AM, Dimmeler S, Rossig Let al., 2004, p21(Cip1) levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization, CIRCULATION RESEARCH, Vol: 94, Pages: 686-692, ISSN: 0009-7330

Journal article

Kulkarni PA, Sano M, Schneider MD, 2004, Phosphorylation of RNA polymerase II in cardiac hypertrophy: Cell enlargement signals converge on cyclin T/Cdk9, RECENT PROGRESS IN HORMONE RESEARCH, VOL 59, Vol: 59, Pages: 125-139, ISSN: 0079-9963

Journal article

Schneider MD, 2004, Regenerative medicine: Prometheus unbound, Nature, Vol: 432, Pages: 451-453

Journal article

Kedzierski RM, Grayburn PA, Kisanuki YY, Williams CS, Hammer RE, Richardson JA, Schneider MD, Yanagisawa Met al., 2003, Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol, MOLECULAR AND CELLULAR BIOLOGY, Vol: 23, Pages: 8226-8232, ISSN: 0270-7306

Journal article

Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, Pocius J, Michael LH, Behringer RR, Garry DJ, Entman ML, Schneider MDet al., 2003, Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 100, Pages: 12313-12318, ISSN: 0027-8424

Journal article

Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, Pocius J, Michael LH, Behringer RR, Garry DJ, Entman ML, Schneider MDet al., 2003, Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction., Proc Natl Acad Sci U S A, Vol: 100, Pages: 12313-12318, ISSN: 0027-8424

Potential repair by cell grafting or mobilizing endogenous cells holds particular attraction in heart disease, where the meager capacity for cardiomyocyte proliferation likely contributes to the irreversibility of heart failure. Whether cardiac progenitors exist in adult myocardium itself is unanswered, as is the question whether undifferentiated cardiac precursor cells merely fuse with preexisting myocytes. Here we report the existence of adult heart-derived cardiac progenitor cells expressing stem cell antigen-1. Initially, the cells express neither cardiac structural genes nor Nkx2.5 but differentiate in vitro in response to 5'-azacytidine, in part depending on Bmpr1a, a receptor for bone morphogenetic proteins. Given intravenously after ischemia/reperfusion, cardiac stem cell antigen 1 cells home to injured myocardium. By using a Cre/Lox donor/recipient pair (alphaMHC-Cre/R26R), differentiation was shown to occur roughly equally, with and without fusion to host cells.

Journal article

Olson EN, Schneider MD, 2003, Sizing up the heart: development redux in disease, GENES & DEVELOPMENT, Vol: 17, Pages: 1937-1956, ISSN: 0890-9369

Journal article

Nakamura T, Schneider MD, 2003, The way to a human's heart is through the stomach - Visceral endoderm-like cells drive human embryonic stem cells to a cardiac fate, CIRCULATION, Vol: 107, Pages: 2638-2639, ISSN: 0009-7322

Journal article

Nakamura T, Sano M, Songyang Z, Schneider MDet al., 2003, A Wnt- and beta-catenin-dependent pathway for mammalian cardiac myogenesis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 100, Pages: 5834-5839, ISSN: 0027-8424

Journal article

Holtwick R, van Eickels M, Skryabin BV, Baba HA, Bubikat A, Begrow F, Schneider MD, Garbers DL, Kuhn Met al., 2003, Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A, JOURNAL OF CLINICAL INVESTIGATION, Vol: 111, Pages: 1399-1407, ISSN: 0021-9738

Journal article

Oh H, Wang SC, Prahash A, Sano M, Moravec CS, Taffett GE, Michael LH, Youker KA, Entman ML, Schneider MDet al., 2003, Telomere attrition and Chk2 activation in human heart failure, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 100, Pages: 5378-5383, ISSN: 0027-8424

Journal article

Ito K, Nakayama M, Hasan F, Yan XH, Schneider MD, Lorell BHet al., 2003, Contractile reserve and calcium regulation are depressed in myocytes from chronically unloaded hearts, CIRCULATION, Vol: 107, Pages: 1176-1182, ISSN: 0009-7322

Journal article

Schneider MD, Gaussin V, Lyons KM, 2003, Tempting fate: BMP signals for cardiac morphogenesis, CYTOKINE & GROWTH FACTOR REVIEWS, Vol: 14, Pages: 1-4, ISSN: 1359-6101

Journal article

Sano M, Schneider MD, 2003, Cyclins That Don't Cycle Cyclin T/Cyclin-Dependent Kinase-9 Determines Cardiac Muscle Cell Size, CELL CYCLE, Vol: 2, Pages: 99-104, ISSN: 1538-4101

Journal article

Bonow R, Clark EB, Curfman GD, Guttmacher A, Hill MN, Miller DC, Morrison AR, Myerburg RJ, Schneider MD, Weisfeldt ML, Willerson JT, Young JBet al., 2002, Task force on strategic research direction - Clinical science subgroup - Key science topics report, CIRCULATION, Vol: 106, Pages: E162-E166, ISSN: 0009-7322

Journal article

Sano M, Abdellatif M, Oh H, Xie M, Bagella L, Giordano A, Michael LH, DeMayo FJ, Schneider MDet al., 2002, Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy, NATURE MEDICINE, Vol: 8, Pages: 1310-1317, ISSN: 1078-8956

Journal article

Minamino T, Yujiri T, Terada N, Taffet GE, Michael LH, Johnson GL, Schneider MDet al., 2002, MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 3866-3871, ISSN: 0027-8424

Journal article

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