Imperial College London

ProfessorMichaelSchneider

Faculty of MedicineNational Heart & Lung Institute

Chair in Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 3027m.d.schneider Website

 
 
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Assistant

 

Miss Cassie Tarquini +44 (0)20 7594 3020

 
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Location

 

336ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Oh:2003:10.1073/pnas.2132126100,
author = {Oh, H and Bradfute, SB and Gallardo, TD and Nakamura, T and Gaussin, V and Mishina, Y and Pocius, J and Michael, LH and Behringer, RR and Garry, DJ and Entman, ML and Schneider, MD},
doi = {10.1073/pnas.2132126100},
journal = {Proc Natl Acad Sci U S A},
pages = {12313--12318},
title = {Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction.},
url = {http://dx.doi.org/10.1073/pnas.2132126100},
volume = {100},
year = {2003}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Potential repair by cell grafting or mobilizing endogenous cells holds particular attraction in heart disease, where the meager capacity for cardiomyocyte proliferation likely contributes to the irreversibility of heart failure. Whether cardiac progenitors exist in adult myocardium itself is unanswered, as is the question whether undifferentiated cardiac precursor cells merely fuse with preexisting myocytes. Here we report the existence of adult heart-derived cardiac progenitor cells expressing stem cell antigen-1. Initially, the cells express neither cardiac structural genes nor Nkx2.5 but differentiate in vitro in response to 5'-azacytidine, in part depending on Bmpr1a, a receptor for bone morphogenetic proteins. Given intravenously after ischemia/reperfusion, cardiac stem cell antigen 1 cells home to injured myocardium. By using a Cre/Lox donor/recipient pair (alphaMHC-Cre/R26R), differentiation was shown to occur roughly equally, with and without fusion to host cells.
AU - Oh,H
AU - Bradfute,SB
AU - Gallardo,TD
AU - Nakamura,T
AU - Gaussin,V
AU - Mishina,Y
AU - Pocius,J
AU - Michael,LH
AU - Behringer,RR
AU - Garry,DJ
AU - Entman,ML
AU - Schneider,MD
DO - 10.1073/pnas.2132126100
EP - 12318
PY - 2003///
SN - 0027-8424
SP - 12313
TI - Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction.
T2 - Proc Natl Acad Sci U S A
UR - http://dx.doi.org/10.1073/pnas.2132126100
UR - https://www.ncbi.nlm.nih.gov/pubmed/14530411
VL - 100
ER -