Imperial College London

ProfessorMichaelSchneider

Faculty of MedicineNational Heart & Lung Institute

Chair in Cardiology
 
 
 
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Contact

 

+44 (0)013 34621727m.d.schneider Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schneider:1996:10.1016/s1071-9164(96)80049-2,
author = {Schneider, MD},
doi = {10.1016/s1071-9164(96)80049-2},
journal = {J Card Fail},
pages = {259--263},
title = {Myocardial infarction as a problem of growth control: cell cycle therapy for cardiac myocytes?},
url = {http://dx.doi.org/10.1016/s1071-9164(96)80049-2},
volume = {2},
year = {1996}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Pump failure after myocardial infarction ultimately can be ascribed, in large part, to the inability of ventricular muscle to regenerate functional mass through cell proliferation. Recent studies using adenoviral gene transfer have provided direct evidence for the operation of two growth-suppressing pathways in cardiac muscle, via "pocket proteins," including the retinoblastoma gene product, and via a less well understood protein, p300. An understanding of molecular mechanisms that confer a virtually irreversible lock to the proliferative cell cycle in "postmitotic" cardiac muscle, together with improved means for delivery of exogenous genes to the heart, suggests the long-term potential for manipulating cardiac growth to achieve a therapeutic benefit.
AU - Schneider,MD
DO - 10.1016/s1071-9164(96)80049-2
EP - 263
PY - 1996///
SN - 1071-9164
SP - 259
TI - Myocardial infarction as a problem of growth control: cell cycle therapy for cardiac myocytes?
T2 - J Card Fail
UR - http://dx.doi.org/10.1016/s1071-9164(96)80049-2
UR - https://www.ncbi.nlm.nih.gov/pubmed/8891864
VL - 2
ER -