Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Chair in Cardiology



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BibTex format

author = {Parker, TG and Chow, KL and Schwartz, RJ and Schneider, MD},
doi = {10.1002/9780470514061.ch10},
journal = {Ciba Found Symp},
pages = {152--160},
title = {TGF-beta 1 and fibroblast growth factors selectively up-regulate tissue-specific fetal genes in cardiac muscle cells.},
url = {},
volume = {157},
year = {1991}

RIS format (EndNote, RefMan)

AB - TGF-beta 1, like basic and acidic fibroblast growth factor (FGF), inhibits differentiated gene expression in skeletal myoblasts. It potentiates FGF-beta 1 down-regulated expression of the alpha-myosin heavy chain gene and the sarcoplasmic reticulum calcium ATPase gene, yet up-regulated expression of the genes for beta-myosin heavy chain, atrial natriuretic factor, and both skeletal and smooth muscle alpha-actin-four transcripts associated with the embryonic heart. TGF-beta 1 did not affect cardiac alpha-actin gene expression. These responses resemble the generalized 'fetal' phenotype seen during hypertrophy triggered by a haemodynamic load. Chick skeletal and cardiac alpha-actin promoter-driven reported genes were transfected into neonatal rat cardiac myocytes. TGF-beta 1 stimulated skeletal alpha-actin transcription, but not transcription from the cardiac alpha-actin promoter. Basic FGF produced the same results as TGF-beta 1, but acidic FGF suppressed expression of both alpha-actin genes; these results were true for purified and recombinant FGFs. Modulation of alpha-actin transcription by growth factors corresponded accurately to control of the endogenous genes. Three positive cis-acting elements were critical for skeletal alpha-actin transcription in cardiac, as well as skeletal, myocytes, particularly the downstream CCAAT box-associated repeat. Thus, TGF-beta 1 and FGFs selectively induce an ensemble of 'fetal' genes and differentially regulate alpha-actin transcription in cardiac muscle cells.
AU - Parker,TG
AU - Chow,KL
AU - Schwartz,RJ
AU - Schneider,MD
DO - 10.1002/9780470514061.ch10
EP - 160
PY - 1991///
SN - 0300-5208
SP - 152
TI - TGF-beta 1 and fibroblast growth factors selectively up-regulate tissue-specific fetal genes in cardiac muscle cells.
T2 - Ciba Found Symp
UR -
UR -
VL - 157
ER -