Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Chair in Cardiology



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BibTex format

author = {Wei, K and Serpooshan, V and Hurtado, C and Diez-Cunado, M and Zhao, M and Maruyama, S and Zhu, W and Fajardo, G and Noseda, M and Nakamura, K and Tian, X and Liu, Q and Wang, A and Matsuura, Y and Bushway, P and Cai, W and Savchenko, A and Mahmoudi, M and Schneider, MD and van, den Hoff MJB and Butte, MJ and Yang, PC and Walsh, K and Zhou, B and Bernstein, D and Mercola, M and Ruiz-Lozano, P},
doi = {10.1038/nature15372},
journal = {Nature},
pages = {479--485},
title = {Epicardial FSTL1 reconstitution regenerates the adult mammalian heart},
url = {},
volume = {525},
year = {2015}

RIS format (EndNote, RefMan)

AB - The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1). Epicardial Fstl1 declines following myocardial infarction and is replaced by myocardial expression. Myocardial Fstl1 does not promote regeneration, either basally or upon transgenic overexpression. Application of the human Fstl1 protein (FSTL1) via an epicardial patch stimulates cell cycle entry and division of pre-existing cardiomyocytes, improving cardiac function and survival in mouse and swine models of myocardial infarction. The data suggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration would be an effective way to reverse myocardial death and remodelling following myocardial infarction in humans.
AU - Wei,K
AU - Serpooshan,V
AU - Hurtado,C
AU - Diez-Cunado,M
AU - Zhao,M
AU - Maruyama,S
AU - Zhu,W
AU - Fajardo,G
AU - Noseda,M
AU - Nakamura,K
AU - Tian,X
AU - Liu,Q
AU - Wang,A
AU - Matsuura,Y
AU - Bushway,P
AU - Cai,W
AU - Savchenko,A
AU - Mahmoudi,M
AU - Schneider,MD
AU - van,den Hoff MJB
AU - Butte,MJ
AU - Yang,PC
AU - Walsh,K
AU - Zhou,B
AU - Bernstein,D
AU - Mercola,M
AU - Ruiz-Lozano,P
DO - 10.1038/nature15372
EP - 485
PY - 2015///
SN - 0028-0836
SP - 479
TI - Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
T2 - Nature
UR -
UR -
VL - 525
ER -