Imperial College London

ProfessorMichaelSchneider

Faculty of MedicineNational Heart & Lung Institute

Chair in Cardiology
 
 
 
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Contact

 

+44 (0)013 34621727m.d.schneider Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hasham:2017:10.1242/dmm.027409,
author = {Hasham, MG and Baxan, N and Stuckey, D and Dent, O and Branca, J and Perkins, BRA and Duffy, T and Hameed, TS and Stella, SE and Bellahcene, M and Schneider, MD and Harding, SE and Rosenthal, N and Sattler, S},
doi = {10.1242/dmm.027409},
journal = {Disease Models & Mechanisms},
pages = {259--270},
title = {Systemic autoimmunity induced by Toll-like receptor 7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy: a new model of autoimmune heart disease},
url = {http://dx.doi.org/10.1242/dmm.027409},
volume = {10},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Systemic autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here we characterize immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the TLR-7/8 agonist Resiquimod. We observe a cardiac phenotype reminiscent of autoimmune-mediated dilated cardiomyopathy, and identify auto-antibodies as major contributors to cardiac tissue damage. Resiquimod-induced heart disease is a highly relevant mouse model for mechanistic and therapeutic studies aiming to protect the heart during autoimmunity.
AU - Hasham,MG
AU - Baxan,N
AU - Stuckey,D
AU - Dent,O
AU - Branca,J
AU - Perkins,BRA
AU - Duffy,T
AU - Hameed,TS
AU - Stella,SE
AU - Bellahcene,M
AU - Schneider,MD
AU - Harding,SE
AU - Rosenthal,N
AU - Sattler,S
DO - 10.1242/dmm.027409
EP - 270
PY - 2017///
SN - 1754-8411
SP - 259
TI - Systemic autoimmunity induced by Toll-like receptor 7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy: a new model of autoimmune heart disease
T2 - Disease Models & Mechanisms
UR - http://dx.doi.org/10.1242/dmm.027409
UR - http://hdl.handle.net/10044/1/44151
VL - 10
ER -