Imperial College London

ProfessorMichaelSchneider

Faculty of MedicineNational Heart & Lung Institute

Chair in Cardiology
 
 
 
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Contact

 

+44 (0)013 34621727m.d.schneider Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bowling:2018:10.1038/s41467-018-04167-y,
author = {Bowling, S and Di, Gregorio A and Sancho, M and Pozzi, S and Aarts, M and Signore, M and Schneider, M and Martinez, Barbera JP and Gil, J and Rodriguez, TA},
doi = {10.1038/s41467-018-04167-y},
journal = {Nature Communications},
title = {P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development},
url = {http://dx.doi.org/10.1038/s41467-018-04167-y},
volume = {9},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Ensuring the fitness of the pluripotent cells that will contribute to future development is important both for the integrity of the germline and for proper embryogenesis. Consequently, it is becoming increasingly apparent that pluripotent cells can compare their fitness levels and signal the elimination of those cells that are less fit than their neighbours. In mammals the nature of the pathways that communicate fitness remain largely unknown. Here we identify that in the early mouse embryo and upon exit from naive pluripotency, the confrontation of cells with different fitness levels leads to an inhibition of mTOR signalling in the less fit cell type, causing its elimination. We show that during this process, p53 acts upstream of mTOR and is required to repress its activity. Finally, we demonstrate that during normal development around 35% of cells are eliminated by this pathway, highlighting the importance of this mechanism for embryonic development.
AU - Bowling,S
AU - Di,Gregorio A
AU - Sancho,M
AU - Pozzi,S
AU - Aarts,M
AU - Signore,M
AU - Schneider,M
AU - Martinez,Barbera JP
AU - Gil,J
AU - Rodriguez,TA
DO - 10.1038/s41467-018-04167-y
PY - 2018///
SN - 2041-1723
TI - P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-018-04167-y
UR - http://hdl.handle.net/10044/1/58914
VL - 9
ER -