ProfessorMaggieDallman

FARGES O, MORRIS PJ, DALLMAN MJ, 1995, SPONTANEOUS ACCEPTANCE OF RAT-LIVER ALLOGRAFTS IS ASSOCIATED WITH AN EARLY DOWN-REGULATION OF INTRAGRAFT INTERLEUKIN-4 MESSENGER-RNA EXPRESSION, HEPATOLOGY, Vol: 21, Pages: 767-775, ISSN: 0270-9139

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• Citations: 43

FARGES O, 1995, Spontaneous acceptance of rat liver allografts is associated with an early downregulation of intragraft interleukin-4 messenger RNA expression*1, *2, Hepatology, Vol: 21, Pages: 767-775, ISSN: 0270-9139

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ABBS IC, PRATT JR, DALLMAN MJ, SACKS SHet al., 1994, DYNAMICS OF THE EXPRESSION OF THE INTERLEUKIN-2 (IL-2) RECEPTOR IN RAT RENAL-ALLOGRAFTS ANALYZED BY IMMUNOHISTOLOGY, AUTORADIOGRAPHY, AND NUCLEAR IMAGING USING RADIOIODINATED IL-2 PROBES, TRANSPLANTATION, Vol: 58, Pages: 1284-1287, ISSN: 0041-1337

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• Citations: 2

GORDON AC, DALLMAN MJ, MORRIS PJ, 1994, VASCULAR ANASTOMOTIC TECHNIQUES FOR EXPERIMENTAL INTESTINAL TRANSPLANTATION, TRANSPLANT INTERNATIONAL, Vol: 7, Pages: 368-371, ISSN: 0934-0874

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• Citations: 4

FARGES O, MORRIS PJ, DALLMAN MJ, 1994, SPONTANEOUS ACCEPTANCE OF LIVER ALLOGRAFTS IN THE RAT - ANALYSIS OF THE IMMUNE-RESPONSE, TRANSPLANTATION, Vol: 57, Pages: 171-177, ISSN: 0041-1337

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• Citations: 48

DALLMAN MJ, 1993, CYTOKINES AS MEDIATORS OF ORGAN GRAFT-REJECTION AND TOLERANCE, CURRENT OPINION IN IMMUNOLOGY, Vol: 5, Pages: 788-793, ISSN: 0952-7915

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• Citations: 79

DALLMAN MJ, WOOD KJ, HAMANO K, BUSHELL AR, MORRIS PJ, WOOD MJA, CHARLTON HMet al., 1993, CYTOKINES AND PERIPHERAL TOLERANCE TO ALLOANTIGEN, IMMUNOLOGICAL REVIEWS, Vol: 133, Pages: 5-18, ISSN: 0105-2896

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• Citations: 61

WOOD MJA, SLOAN DJ, DALLMAN MJ, CHARLTON HMet al., 1993, SPECIFIC TOLERANCE TO NEURAL ALLOGRAFTS INDUCED WITH AN ANTIBODY TO THE INTERLEUKIN-2 RECEPTOR, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 177, Pages: 597-603, ISSN: 0022-1007

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• Citations: 29

MORRIS PJ, DALLMAN MJ, WOOD KJ, 1993, ANERGY IN ALLOGENEIC TRANSPLANTATION, TRANSPLANTATION PROCEEDINGS, Vol: 25, Pages: 281-283, ISSN: 0041-1345

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• Citations: 12

Abbs IC, Pratt JR, Dallman MJ, Sacks SHet al., 1993, Analysis of activated T cell infiltrates in rat renal allografts by gamma camera imaging after injection of 123iodine-interleukin 2., Transpl Immunol, Vol: 1, Pages: 45-51, ISSN: 0966-3274

Activated T cells bearing receptors for interleukin 2 (IL-2) play an important role in immunity and in immunopathological processes such as allograft rejection. In order to investigate the presence of activated T cells in lymphocytic infiltrates in transplanted kidneys, we investigated the uptake and retention of radioactivity after an intravenous injection of radioiodinated IL-2 in experimentally transplanted rats. IL-2 was enzyme radiolabelled with 123iodine using a glucose oxidase/lactoperoxidase method and shown to retain specific binding on an IL-2 receptor positive cell line, C58E6. To examine the kinetics of 123iodine-interleukin 2 (123I-IL-2) uptake in vivo, animals that had been transplanted five days previously with allogeneic or syngeneic grafts were injected with 123I-IL-2 and then imaged using an external gamma camera. Radioactivity was measured at time points up to 240 min after intravenous injection of 123I-IL-2. Four groups of animals were examined: allogeneic grafts (n = 7); syngeneic grafts (n = 6); ischaemic native kidneys (n = 5) all following injection with 123I-IL-2; and allogeneic transplants (n = 5) after injection of 123I-lactalbumin, an irrelevant molecule of similar molecular weight to IL-2. The peak radioactivity after injection was measured and the amount of radioactivity retained in the graft at increasing time intervals after injection was expressed as a function of initial peak radioactivity. At four hours after injection of 123I-IL-2, mean retention of activity by rejecting grafts was 77(+/- 2.68)% of peak activity, compared to 45(+/- 6.38)% in syngeneic controls (p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

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BAIGRIE RJ, LAMONT PM, KWIATKOWSKI D, DALLMAN MJ, MORRIS PJet al., 1992, SYSTEMIC CYTOKINE RESPONSE AFTER MAJOR SURGERY, BRITISH JOURNAL OF SURGERY, Vol: 79, Pages: 757-760, ISSN: 0007-1323

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• Citations: 499

WOOD MJA, SLOAN DJ, DALLMAN MJ, CHARLTON HMet al., 1992, A MONOCLONAL-ANTIBODY TO THE INTERLEUKIN-2 RECEPTOR ENHANCES THE SURVIVAL OF NEURAL ALLOGRAFTS - A TIME-COURSE STUDY, NEUROSCIENCE, Vol: 49, Pages: 409-418, ISSN: 0306-4522

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• Citations: 26

DALLMAN MJ, ROAKE J, HUGHES D, TOOGOOD G, MORRIS PJet al., 1992, SEQUENTIAL-ANALYSIS OF IL-2 GENE-TRANSCRIPTION IN RENAL-TRANSPLANTS, TRANSPLANTATION, Vol: 53, Pages: 683-685, ISSN: 0041-1337

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• Citations: 74

CLARK GJ, DALLMAN MJ, 1992, IDENTIFICATION OF A CDNA-ENCODING THE RAT CD28 HOMOLOG, IMMUNOGENETICS, Vol: 35, Pages: 54-57, ISSN: 0093-7711

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• Citations: 21

GORDON AC, DALLMAN MJ, MORRIS PJ, 1992, CELLULAR INFILTRATION OF SMALL-BOWEL ALLOGRAFTS, GUT, Vol: 33, Pages: S7-S7, ISSN: 0017-5749

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MORRIS PJ, WOOD KJ, DALLMAN MJ, 1991, ANTIGEN-INDUCED TOLERANCE TO ORGAN ALLOGRAFTS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, Vol: 636, Pages: 295-305

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• Citations: 12

DALLMAN MJ, CLARK GJ, 1991, CYTOKINES AND THEIR RECEPTORS IN TRANSPLANTATION, CURRENT OPINION IN IMMUNOLOGY, Vol: 3, Pages: 729-734, ISSN: 0952-7915

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• Citations: 15

PAGE TH, DALLMAN MJ, 1991, MOLECULAR-CLONING OF CDNAS FOR THE RAT INTERLEUKIN-2 RECEPTOR ALPHA-CHAIN AND BETA-CHAIN GENES - DIFFERENTIALLY REGULATED GENE ACTIVITY IN RESPONSE TO MITOGENIC STIMULATION, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 21, Pages: 2133-2138, ISSN: 0014-2980

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• Citations: 22

DALLMAN MJ, LARSEN CP, MORRIS PJ, 1991, CYTOKINE GENE-TRANSCRIPTION IN VASCULARIZED ORGAN GRAFTS - ANALYSIS USING SEMIQUANTITATIVE POLYMERASE CHAIN-REACTION, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 174, Pages: 493-496, ISSN: 0022-1007

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• Citations: 294

MONTGOMERY RA, DALLMAN MJ, 1991, ANALYSIS OF CYTOKINE GENE-EXPRESSION DURING FETAL THYMIC ONTOGENY USING THE POLYMERASE CHAIN-REACTION, JOURNAL OF IMMUNOLOGY, Vol: 147, Pages: 554-560, ISSN: 0022-1767

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• Citations: 219

DALLMAN MJ, MONTGOMERY RA, LARSEN CP, WANDERS A, WELLS AFet al., 1991, CYTOKINE GENE-EXPRESSION - ANALYSIS USING NORTHERN BLOTTING, POLYMERASE CHAIN-REACTION AND INSITU HYBRIDIZATION, IMMUNOLOGICAL REVIEWS, Vol: 119, Pages: 163-179, ISSN: 0105-2896

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• Citations: 125

DALLMAN MJ, SHIHO O, PAGE TH, WOOD KJ, MORRIS PJet al., 1991, Peripheral tolerance to alloantigen results from altered regulation of the interleukin-2 pathway, Journal of Experimental Medicine, Vol: 173, Pages: 79-87, ISSN: 0022-1007

Tolerance to alloantigen may be induced in rats by administration of blood followed by transplantation of a renal allograft. The mechanism of this tolerance was investigated by directly analyzing the functional activity of graft-infiltrating cells. We have previously shown cytotoxic T lymphocyte infiltration of, and major histocompatibility complex induction on, grafts of tolerant animals. We now report that cells isolated from the grafts of tolerant rats show a reduced expression of the p55 interleukin 2 receptor (IL-2R) chain on the cell surface compared with that seen on the cells of untreated animals. Scatchard analysis further reveals low expression of high affinity IL-2R. This is due to reduced transcription of both IL-2R alpha and beta chain mRNAs and results in a reduced ability of cells to proliferate in response to IL-2. Cells isolated from tolerant animals are unable to make biologically active IL-2 in culture, whereas cells from untreated animals make high levels. This is not reflected at the mRNA level as the IL-2 gene is induced in both tolerant and untreated animals to similar levels. The induction of tolerance is abrogated by administration of recombinant IL-2 to animals at the time of transplantation. Thus, we conclude that an altered regulation of the IL-2 pathway results in tolerance in these alloantigen-treated and transplanted animals.

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CLARKE DJ, HONEY CR, DALLMAN MJ, CHARLTON HMet al., 1991, SURVIVAL OF HUMAN FETAL GRAFTS IN A RAT MODEL OF PARKINSONS-DISEASE - ALTERNATIVE METHODS OF IMMUNOSUPPRESSION, 20TH FERNSTROM SYMP ON INTRACEREBRAL TRANSPLANTATION IN MOVEMENT DISORDERS : EXPERIMENTAL BASIS AND CLINICAL EXPERIENCES, Publisher: ELSEVIER SCIENCE PUBL B V, Pages: 193-197

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FARGES O, DALLMAN MJ, MORRIS PJ, 1991, PHENOTYPIC AND FUNCTIONAL-STUDY OF GRAFT INFILTRATING CELLS IN RAT-LIVER TRANSPLANTATION, INTERNATIONAL WORKSHOP ON EXPERIMENTAL AND CLINICAL LIVER TRANSPLANTATION, Publisher: ELSEVIER SCIENCE PUBL B V, Pages: 37-38

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MORRIS PJ, WOOD KJ, DALLMAN MJ, 1991, ANTIGEN-INDUCED TOLERANCE TO ORGAN ALLOGRAFTS, CONF ON ANTIGEN AND CLONE-SPECIFIC IMMUNOREGULATION, Publisher: NEW YORK ACAD SCIENCES, Pages: 295-305, ISSN: 0077-8923

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Honey CR, Clarke DJ, Dallman MJ, Charlton HMet al., 1990, Human neural graft function in rats treated with anti-interleukin II receptor antibody., Neuroreport, Vol: 1, Pages: 247-249, ISSN: 0959-4965

Prolonged immunosuppression with cyclosporin A allows survival of human xenografts in the rat Parkinsonian model but the drug has side effects. Ideally immunosuppression should be of short duration, to minimize the chance of infection, yet be capable of supporting long term survival of the transplanted tissue. We report that short term treatment with an anti-rat interleukin II receptor (IL2R) monoclonal antibody (MAb) resulted in apparently permanent survival of human fetal dopaminergic grafts in "Parkinsonian" rats. The recipients remained healthy and the excellent survival of the transplants suggests that the antibody injection strategy would almost certainly abrogate allograft rejection and raises the possibility that xenogenic dopaminergic neurones could be used as donor tissue in humans.

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SUTTON R, GRAY DWR, MCSHANE P, DALLMAN MJ, MORRIS PJet al., 1989, THE SPECIFICITY OF REJECTION AND THE ABSENCE OF SUSCEPTIBILITY OF PANCREATIC-ISLET BETA-CELLS TO NONSPECIFIC IMMUNE DESTRUCTION IN MIXED STRAIN ISLETS GRAFTED BENEATH THE RENAL CAPSULE IN THE RAT, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 170, Pages: 751-762, ISSN: 0022-1007

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• Citations: 49

HUGHES DA, BITTAR CM, GLOVER LG, DALLMAN MJ, RICHARDSON AJ, MORRIS PJet al., 1989, ANALYSIS OF CELL-POPULATIONS IN FINE NEEDLE ASPIRATION BIOPSIES FROM HUMAN RENAL-ALLOGRAFTS BY SEPARATION ON A PREFORMED CONTINUOUS PERCOLL DENSITY GRADIENT, TRANSPLANTATION PROCEEDINGS, Vol: 21, Pages: 3591-3592, ISSN: 0041-1345

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• Citations: 1

TELLIDES G, DALLMAN MJ, MORRIS PJ, 1989, MECHANISM OF ACTION OF INTERLEUKIN-2 RECEPTOR (IL-2R) MONOCLONAL-ANTIBODY (MAB) THERAPY - TARGET-CELL DEPLETION OR INHIBITION OF FUNCTION, TRANSPLANTATION PROCEEDINGS, Vol: 21, Pages: 997-998, ISSN: 0041-1345

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• Citations: 51

DALLMAN MJ, PORTER ACG, LARSEN CP, MORRIS PJet al., 1989, LYMPHOKINE PRODUCTION IN ALLOGRAFTS - ANALYSIS OF RNA BY NORTHERN BLOTTING, TRANSPLANTATION PROCEEDINGS, Vol: 21, Pages: 296-298, ISSN: 0041-1345

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