Imperial College London
Alternate

DrMarinaEvangelou

Faculty of Natural Sciences, Department of Mathematics

Senior Lecturer in Statistics
 
 
 
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Contact

 

+44 (0)20 7594 7184m.evangelou

 
 
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Location

 

546Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@misc{Aglago:2023:10.1158/0008-5472.c.6769316.v1,
author = {Aglago, EK and Kim, A and Lin, Y and Qu, C and Evangelou, M and Ren, Y and Morrison, J and Albanes, D and Arndt, V and Barry, EL and Baurley, JW and Berndt, SI and Bien, SA and Bishop, DT and Bouras, E and Brenner, H and Buchanan, DD and Budiarto, A and Carreras-Torres, R and Casey, G and Cenggoro, TW and Chan, AT and Chang-Claude, J and Chen, X and Conti, DV and Devall, M and Diez-Obrero, V and Dimou, N and Drew, D and Figueiredo, JC and Gallinger, S and Giles, GG and Gruber, SB and Gsur, A and Gunter, MJ and Hampel, H and Harlid, S and Hidaka, A and Harrison, TA and Hoffmeister, M and Huyghe, JR and Jenkins, MA and Jordahl, K and Joshi, AD and Kawaguchi, ES and Keku, TO and Kundaje, A and Larsson, SC and Marchand, LL and Lewinger, JP and Li, L and Lynch, BM and Mahesworo, B and Mandic, M and Obón-Santacana, M and Moreno, V and Murphy, N and Nan, H and Nassir, R and Newcomb, PA and Ogino, S and Ose, J and Pai, RK and Palmer, JR and Papadimitriou, N and Pardamean, B and Peoples, AR and},
doi = {10.1158/0008-5472.c.6769316.v1},
title = {Data from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk},
type = {Other},
url = {http://dx.doi.org/10.1158/0008-5472.c.6769316.v1},
year = {2023}
}
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TY  - GEN
AB  - <jats:p><div>Abstract<p>Colorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Gene-environment interactions (G × E) can provide biological insights into the effects of obesity on colorectal cancer risk. Here, we assessed potential genome-wide G × E interactions between body mass index (BMI) and common SNPs for colorectal cancer risk using data from 36,415 colorectal cancer cases and 48,451 controls from three international colorectal cancer consortia (CCFR, CORECT, and GECCO). The G × E tests included the conventional logistic regression using multiplicative terms (one degree of freedom, 1DF test), the two-step EDGE method, and the joint 3DF test, each of which is powerful for detecting G × E interactions under specific conditions. BMI was associated with higher colorectal cancer risk. The two-step approach revealed a statistically significant G×BMI interaction located within the Formin 1/Gremlin 1 (<i>FMN1/GREM1</i>) gene region (rs58349661). This SNP was also identified by the 3DF test, with a suggestive statistical significance in the 1DF test. Among participants with the CC genotype of rs58349661, overweight and obesity categories were associated with higher colorectal cancer risk, whereas null associations were observed across BMI categories in those with the TT genotype. Using data from three large international consortia, this study discovered a locus in the <i>FMN1/GREM1</i> gene region that interacts with BMI on the association with colorectal cancer risk. Further studies should examine the potential mechanisms through which this locus modifies the etiologic link between obesity and colorectal cancer.</p>Significance:<p>This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal
AU  - Aglago,EK
AU  - Kim,A
AU  - Lin,Y
AU  - Qu,C
AU  - Evangelou,M
AU  - Ren,Y
AU  - Morrison,J
AU  - Albanes,D
AU  - Arndt,V
AU  - Barry,EL
AU  - Baurley,JW
AU  - Berndt,SI
AU  - Bien,SA
AU  - Bishop,DT
AU  - Bouras,E
AU  - Brenner,H
AU  - Buchanan,DD
AU  - Budiarto,A
AU  - Carreras-Torres,R
AU  - Casey,G
AU  - Cenggoro,TW
AU  - Chan,AT
AU  - Chang-Claude,J
AU  - Chen,X
AU  - Conti,DV
AU  - Devall,M
AU  - Diez-Obrero,V
AU  - Dimou,N
AU  - Drew,D
AU  - Figueiredo,JC
AU  - Gallinger,S
AU  - Giles,GG
AU  - Gruber,SB
AU  - Gsur,A
AU  - Gunter,MJ
AU  - Hampel,H
AU  - Harlid,S
AU  - Hidaka,A
AU  - Harrison,TA
AU  - Hoffmeister,M
AU  - Huyghe,JR
AU  - Jenkins,MA
AU  - Jordahl,K
AU  - Joshi,AD
AU  - Kawaguchi,ES
AU  - Keku,TO
AU  - Kundaje,A
AU  - Larsson,SC
AU  - Marchand,LL
AU  - Lewinger,JP
AU  - Li,L
AU  - Lynch,BM
AU  - Mahesworo,B
AU  - Mandic,M
AU  - Obón-Santacana,M
AU  - Moreno,V
AU  - Murphy,N
AU  - Nan,H
AU  - Nassir,R
AU  - Newcomb,PA
AU  - Ogino,S
AU  - Ose,J
AU  - Pai,RK
AU  - Palmer,JR
AU  - Papadimitriou,N
AU  - Pardamean,B
AU  - Peoples,AR
AU  - Platz,EA
AU  - Potter,JD
AU  - Prentice,RL
AU  - Rennert,G
AU  - Ruiz-Narvaez,E
AU  - Sakoda,LC
AU  - Scacheri,PC
AU  - Schmit,SL
AU  - Schoen,RE
AU  - Shcherbina,A
AU  - Slattery,ML
AU  - Stern,MC
AU  - Su,Y-R
AU  - Tangen,CM
AU  - Thibodeau,SN
AU  - Thomas,DC
AU  - Tian,Y
AU  - Ulrich,CM
AU  - van,Duijnhoven FJB
AU  - Van,Guelpen B
AU  - Visvanathan,K
AU  - Vodicka,P
AU  - Wang,J
AU  - White,E
AU  - Wolk,A
AU  - Woods,MO
AU  - Wu,AH
AU  - Zemlianskaia,N
AU  - Hsu,L
AU  - Gauderman,WJ
AU  - Peters,U
AU  - Tsilidis,KK
AU  - Campbell,PT
DO  - 10.1158/0008-5472.c.6769316.v1
PY  - 2023///
TI  - Data from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk
UR  - http://dx.doi.org/10.1158/0008-5472.c.6769316.v1
ER  -
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