Imperial College London

Professor Matthew J. Fuchter

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5815m.fuchter

 
 
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Location

 

401CMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Publication Type
Year
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120 results found

Cherblanc FL, Lo Y-P, Herrebout WA, Bultinck P, Rzepa HS, Fuchter MJet al., 2013, Mechanistic and Chiroptical Studies on the Desulfurization of Epidithiodioxopiperazines Reveal Universal Retention of Configuration at the Bridgehead Carbon Atoms, JOURNAL OF ORGANIC CHEMISTRY, Vol: 78, Pages: 11646-11655, ISSN: 0022-3263

Journal article

Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, DiMaggio PA, Brown R, Fuchter MJet al., 2013, On the Histone Lysine Methyltransferase Activity of Fungal Metabolite Chaetocin, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 56, Pages: 8616-8625, ISSN: 0022-2623

Journal article

Judge DK, Haycock P, Richardson RD, Fuchter MJet al., 2013, ortho-Substituted 1,8-Diarylnaphthalenes: Conformational Thermodynamics and Kinetics, SYNLETT, Vol: 24, Pages: 2365-2369, ISSN: 0936-5214

Journal article

Kaliszczak M, Patel H, Kroll SHB, Carroll L, Smith G, Delaney S, Heathcote DA, Bondke A, Fuchter MJ, Coombes RC, Barrett AGM, Ali S, Aboagye EOet al., 2013, Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance, British Journal of Cancer, Vol: 109, Pages: 2356-2367, ISSN: 1532-1827

background: Cyclin-dependent kinases (CDKs) control cell cycle progression, RNA transcription and apoptosis, making them attractive targets for anticancer drug development. Unfortunately, CDK inhibitors developed to date have demonstrated variable efficacy.methods: We generated drug-resistant cells by continuous low-dose exposure to a model pyrazolo[1,5-a]pyrimidine CDK inhibitor and investigated potential structural alterations for optimal efficacy.results: We identified induction of the ATP-binding cassette (ABC) transporters, ABCB1 and ABCG2, in resistant cells. Assessment of features involved in the ABC transporter substrate specificity from a compound library revealed high polar surface area (>100 Å2) as a key determinant of transporter interaction. We developed ICEC-0782 that preferentially inhibited CDK2, CDK7 and CDK9 in the nanomolar range. The compound inhibited phosphorylation of CDK substrates and downregulated the short-lived proteins, Mcl-1 and cyclin D1. ICEC-0782 induced G2/M arrest and apoptosis. The permeability and cytotoxicity of ICEC-0782 were unaffected by ABC transporter expression. Following daily oral dosing, the compound inhibited growth of human colon HCT-116 and human breast MCF7 tumour xenografts in vivo by 84% and 94%, respectively.conclusion: We identified a promising pyrazolo[1,5-a]pyrimidine compound devoid of ABC transporter interaction, highly suitable for further preclinical and clinical evaluation for the treatment of cancer.

Journal article

Yang Y, Correa da Costa R, Fuchter MJ, Campbell AJet al., 2013, Circularly polarized light detection by a chiralorganic semiconductor transistor, Nature Photonics, Vol: 7, Pages: 634-638

Journal article

Yang Y, da Costa RC, Smilgies D-M, Campbell AJ, Fuchter MJet al., 2013, Induction of Circularly Polarized Electroluminescence from an Achiral Light-Emitting Polymer via a Chiral Small-Molecule Dopant, ADVANCED MATERIALS, Vol: 25, Pages: 2624-2628, ISSN: 0935-9648

Journal article

Weimar M, Correa da Costa R, Lee F-H, Fuchter MJet al., 2013, A Scalable and Expedient Route to 1‐Aza[6]helicene Derivatives and Its Subsequent Application to a Chiral-Relay Asymmetric Strategy, Organic Letters, Vol: 15, Pages: 1706-1709

Journal article

Cherblanc F, Chapman KL, Brown R, Fuchter MJet al., 2013, Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases, Nature Chemical Biology, Vol: 9, Pages: 136-137

Journal article

Baud MGJ, Leiser T, Petrucci V, Gunaratnam M, Neidle S, Meyer-Amles FJ, Fuchter MJet al., 2013, Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors, Beilstein Journal of Organic Chemistry, Vol: 9, Pages: 81-88

Journal article

Fuchter MJ, Judge DK, Weimar M, White AJPet al., 2013, Stoichiometric C-H arylation of tricarbonyl(arene)-chromium complexes bearing pyridine directing groups, DALTON TRANSACTIONS, Vol: 42, Pages: 5615-5618, ISSN: 1477-9226

Journal article

Baud MGJ, Haus P, Leiser T, Meyer-Almes F-J, Fuchter MJet al., 2013, Highly Ligand Efficient and Selective N-2(Thioethyl)picolinamide Histone Deacetylase Inhibitors Inspired by the Natural Product Psammaplin A, CHEMMEDCHEM, Vol: 8, Pages: 149-156, ISSN: 1860-7179

Journal article

Weimar M, Fuchter MJ, 2013, Synthesis of sterically encumbered C10-arylated benzo[h]quinolines using ortho-substituted aryl boronic acids, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 11, Pages: 31-34, ISSN: 1477-0520

Journal article

Cherblanc FL, Davidson RWM, Di Fruscia P, Srimongkolpithak N, Fuchter MJet al., 2013, Perspectives on natural product epigenetic modulators in chemical biology and medicine, NATURAL PRODUCT REPORTS, Vol: 30, Pages: 605-624, ISSN: 0265-0568

Journal article

Malmquist NA, Moss TA, Mecheri S, Scherf A, Fuchter MJet al., 2012, Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 16708-16713, ISSN: 0027-8424

Journal article

Forkel NV, Henderson DA, Fuchter MJ, 2012, Lanthanide Replacement in Organic Synthesis: Luche-Type Reduction of a,ß-Unsaturated Ketones in the Presence of Calcium triflate, Green Chemistry, Vol: 14, Pages: 2129-2132

Journal article

Cherblanc F, Chapman-Rothe N, Brown R, Fuchter MJet al., 2012, Current limitations and future opportunities for epigenetic therapies, Future Medicinal Chemistry, Vol: 4, Pages: 425-446

Journal article

Fuchter MJ, Weimar M, Yang X, Judge DK, White AJPet al., 2012, An Unusual Oxidative Rearrangement of [7]-Helicene, Tetrahedron Letters, Vol: 53, Pages: 1108-1111

Journal article

Baud MGJ, Leiser T, Haus P, Samlal S, Wong AC, Wood RJ, Petrucci V, Gunaratnam M, Hughes SM, Buluwela L, Turlais F, Neidle S, Meyer-Almes F-J, White AJP, Fuchter MJet al., 2012, Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 55, Pages: 1731-1750, ISSN: 0022-2623

Journal article

Di Fruscia P, Ho K-K, Laohasinnarong S, Khonghow M, Kroll SHB, Islam SA, Sternberg MJE, Schmidtkunz K, Jung M, Lam EW-F, Fuchter MJet al., 2012, The discovery of novel 10,11-dihydro-5H-dibenz[b,f]azepine SIRT2 inhibitors, MedChemComm

Journal article

Levy J-N, Latham CM, Roisin L, Kandziora N, Di Fruscia P, White AJP, Woodward S, Fuchter MJet al., 2012, The design and synthesis of novel IBiox N-heterocyclic carbene ligands derived from substituted amino-indanols, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 10, Pages: 512-515, ISSN: 1477-0520

Journal article

Fuchter MJ, Schaefer J, Judge DK, Wardzinski B, Weimar M, Krossing Iet al., 2012, [7]-Helicene: a chiral molecular tweezer for silver(I) salts, DALTON TRANSACTIONS, Vol: 41, Pages: 8238-8241, ISSN: 1477-9226

Journal article

Cherblanc F, Lo Y-P, De Gussem E, Alcazar-Fuoli L, Bignell E, He Y, Chapman-Rothe N, Bultinck P, Herrebout WA, Brown R, Rzepa HS, Fuchter MJet al., 2011, On the Determination of the Stereochemistry of Semisynthetic Natural Product Analogues using Chiroptical Spectroscopy: Desulfurization of Epidithiodioxopiperazine Fungal Metabolites, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 17, Pages: 11868-11875, ISSN: 0947-6539

Journal article

Scherf A, Malmquist NA, Moss TA, Fuchter MJet al., 2011, The study of antigenic variation in Plasmodium falciparum: mind games or a novel therapeutic approach, 36th FEBS Congress of the Biochemistry for Tomorrows Medicine, Publisher: WILEY-BLACKWELL, Pages: 62-63, ISSN: 1742-464X

Conference paper

Haider S, Joseph CG, Neidle S, Fierke CA, Fuchter MJet al., 2011, On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol: 21, Pages: 2129-2132, ISSN: 0960-894X

Journal article

Baud MGJ, Leiser T, Meyer-Almes F-J, Fuchter MJet al., 2011, New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 9, Pages: 659-662, ISSN: 1477-0520

Journal article

Fuchter MJ, 2010, Simmons-Smith Cyclopropanation, Name Reactions for Carbocyclic Ring Formations, Editors: Corey, Li, New York, Publisher: Wiley, Pages: 24-44, ISBN: 978-0-470-08506-6

Book chapter

Fuchter MJ, 2010, Nazarov Cyclization, Name Reactions for Carbocyclic Ring Formations, Editors: Corey, Li, New York, Publisher: Wiley, Pages: 122-146, ISBN: 978-0-470-08506-6

Book chapter

Liotta DC, Synder JP, Jogalekar AS, Barrett AGM, Fuchter MJ, Cook M, Kroll SHBet al., 2010, Processes for preparing 5,7-diaminopyrazolo[1,5-.alpha.]pyrimidine derivatives via regioselective aminations of dichloro(pyrazolo)pyrimidines with primary and secondary amines., WO 2010068838

Patent

Saubern S, Macdonald JM, Ryan JH, Woodgate RCJ, Louie TS, Fuchter MJ, White JM, Holmes ABet al., 2010, Tricyclic-isoxazolidine analogues via intramolecular 1,3-dipolar cycloaddition reactions of nitrones, TETRAHEDRON, Vol: 66, Pages: 2761-2767, ISSN: 0040-4020

Journal article

Peck B, Chen C-Y, Ho K-K, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao C-D, Lam EW-Fet al., 2010, SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2, MOLECULAR CANCER THERAPEUTICS, Vol: 9, Pages: 844-855, ISSN: 1535-7163

Journal article

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