Imperial College London

Professor Matthew J. Fuchter

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5815m.fuchter

 
 
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Location

 

401CMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

109 results found

Weimar M, Correa da Costa R, Lee F-H, Fuchter MJet al., 2013, A Scalable and Expedient Route to 1‐Aza[6]helicene Derivatives and Its Subsequent Application to a Chiral-Relay Asymmetric Strategy, Organic Letters, Vol: 15, Pages: 1706-1709

Journal article

Cherblanc F, Chapman KL, Brown R, Fuchter MJet al., 2013, Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases, Nature Chemical Biology, Vol: 9, Pages: 136-137

Journal article

Baud MGJ, Leiser T, Petrucci V, Gunaratnam M, Neidle S, Meyer-Amles FJ, Fuchter MJet al., 2013, Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors, Beilstein Journal of Organic Chemistry, Vol: 9, Pages: 81-88

Journal article

Fuchter MJ, Judge DK, Weimar M, White AJPet al., 2013, Stoichiometric C-H arylation of tricarbonyl(arene)-chromium complexes bearing pyridine directing groups, DALTON TRANSACTIONS, Vol: 42, Pages: 5615-5618, ISSN: 1477-9226

Journal article

Baud MGJ, Haus P, Leiser T, Meyer-Almes F-J, Fuchter MJet al., 2013, Highly Ligand Efficient and Selective N-2(Thioethyl)picolinamide Histone Deacetylase Inhibitors Inspired by the Natural Product Psammaplin A, CHEMMEDCHEM, Vol: 8, Pages: 149-156, ISSN: 1860-7179

Journal article

Weimar M, Fuchter MJ, 2013, Synthesis of sterically encumbered C10-arylated benzo[h]quinolines using ortho-substituted aryl boronic acids, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 11, Pages: 31-34, ISSN: 1477-0520

Journal article

Cherblanc FL, Davidson RWM, Di Fruscia P, Srimongkolpithak N, Fuchter MJet al., 2013, Perspectives on natural product epigenetic modulators in chemical biology and medicine, NATURAL PRODUCT REPORTS, Vol: 30, Pages: 605-624, ISSN: 0265-0568

Journal article

Malmquist NA, Moss TA, Mecheri S, Scherf A, Fuchter MJet al., 2012, Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 16708-16713, ISSN: 0027-8424

Journal article

Forkel NV, Henderson DA, Fuchter MJ, 2012, Lanthanide Replacement in Organic Synthesis: Luche-Type Reduction of a,ß-Unsaturated Ketones in the Presence of Calcium triflate, Green Chemistry, Vol: 14, Pages: 2129-2132

Journal article

Cherblanc F, Chapman-Rothe N, Brown R, Fuchter MJet al., 2012, Current limitations and future opportunities for epigenetic therapies, Future Medicinal Chemistry, Vol: 4, Pages: 425-446

Journal article

Fuchter MJ, Weimar M, Yang X, Judge DK, White AJPet al., 2012, An Unusual Oxidative Rearrangement of [7]-Helicene, Tetrahedron Letters, Vol: 53, Pages: 1108-1111

Journal article

Baud MGJ, Leiser T, Haus P, Samlal S, Wong AC, Wood RJ, Petrucci V, Gunaratnam M, Hughes SM, Buluwela L, Turlais F, Neidle S, Meyer-Almes F-J, White AJP, Fuchter MJet al., 2012, Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 55, Pages: 1731-1750, ISSN: 0022-2623

Journal article

Di Fruscia P, Ho K-K, Laohasinnarong S, Khonghow M, Kroll SHB, Islam SA, Sternberg MJE, Schmidtkunz K, Jung M, Lam EW-F, Fuchter MJet al., 2012, The discovery of novel 10,11-dihydro-5H-dibenz[b,f]azepine SIRT2 inhibitors, MedChemComm

Journal article

Fuchter MJ, Schaefer J, Judge DK, Wardzinski B, Weimar M, Krossing Iet al., 2012, [7]-Helicene: a chiral molecular tweezer for silver(I) salts, DALTON TRANSACTIONS, Vol: 41, Pages: 8238-8241, ISSN: 1477-9226

Journal article

Levy J-N, Latham CM, Roisin L, Kandziora N, Di Fruscia P, White AJP, Woodward S, Fuchter MJet al., 2012, The design and synthesis of novel IBiox N-heterocyclic carbene ligands derived from substituted amino-indanols, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 10, Pages: 512-515, ISSN: 1477-0520

Journal article

Cherblanc F, Lo Y-P, De Gussem E, Alcazar-Fuoli L, Bignell E, He Y, Chapman-Rothe N, Bultinck P, Herrebout WA, Brown R, Rzepa HS, Fuchter MJet al., 2011, On the Determination of the Stereochemistry of Semisynthetic Natural Product Analogues using Chiroptical Spectroscopy: Desulfurization of Epidithiodioxopiperazine Fungal Metabolites, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 17, Pages: 11868-11875, ISSN: 0947-6539

Journal article

Scherf A, Malmquist NA, Moss TA, Fuchter MJet al., 2011, The study of antigenic variation in Plasmodium falciparum: mind games or a novel therapeutic approach, 36th FEBS Congress of the Biochemistry for Tomorrows Medicine, Publisher: WILEY-BLACKWELL, Pages: 62-63, ISSN: 1742-464X

Conference paper

Haider S, Joseph CG, Neidle S, Fierke CA, Fuchter MJet al., 2011, On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol: 21, Pages: 2129-2132, ISSN: 0960-894X

Journal article

Baud MGJ, Leiser T, Meyer-Almes F-J, Fuchter MJet al., 2011, New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 9, Pages: 659-662, ISSN: 1477-0520

Journal article

Fuchter MJ, 2010, Simmons-Smith Cyclopropanation, Name Reactions for Carbocyclic Ring Formations, Editors: Corey, Li, New York, Publisher: Wiley, Pages: 24-44, ISBN: 978-0-470-08506-6

Book chapter

Fuchter MJ, 2010, Nazarov Cyclization, Name Reactions for Carbocyclic Ring Formations, Editors: Corey, Li, New York, Publisher: Wiley, Pages: 122-146, ISBN: 978-0-470-08506-6

Book chapter

Liotta DC, Synder JP, Jogalekar AS, Barrett AGM, Fuchter MJ, Cook M, Kroll SHBet al., 2010, Processes for preparing 5,7-diaminopyrazolo[1,5-.alpha.]pyrimidine derivatives via regioselective aminations of dichloro(pyrazolo)pyrimidines with primary and secondary amines., WO 2010068838

Patent

Saubern S, Macdonald JM, Ryan JH, Woodgate RCJ, Louie TS, Fuchter MJ, White JM, Holmes ABet al., 2010, Tricyclic-isoxazolidine analogues via intramolecular 1,3-dipolar cycloaddition reactions of nitrones, TETRAHEDRON, Vol: 66, Pages: 2761-2767, ISSN: 0040-4020

Journal article

Peck B, Chen C-Y, Ho K-K, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao C-D, Lam EW-Fet al., 2010, SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2, MOLECULAR CANCER THERAPEUTICS, Vol: 9, Pages: 844-855, ISSN: 1535-7163

Journal article

Akiyoshi T, Heathcote DA, Azzi J, Zhang M, Rodig SJ, El-Haddad N, Yang S, Moore RF, Sayegh MH, Ashton-Rickardt PG, Abdi Ret al., 2010, The Role of SPI6 in the Survival of Allograft Derived Dendritic Cells and Tolerance., AMERICAN JOURNAL OF TRANSPLANTATION, Vol: 10, Pages: 561-561, ISSN: 1600-6135

Journal article

Heathcote DA, Patel H, Kroll SH, Hazel P, Periyasamy M, Alikian M, Kannegnti SK, Jogalekar AS, Scheiper B, Barbazanges M, Blum A, Brackow J, Siwicka A, Pace RD, Fuchter MJ, Snyder JP, Liotta DC, Freemont PS, Aboagye EO, Coombes RC, Barrett AG, Ali Set al., 2010, A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration, J Med Chem, Vol: 53, Pages: 8508-8522

Cyclin-dependent protein kinases (CDKs) are central to the appropriate regulation of cell proliferation, apoptosis, and gene expression. Abnormalities in CDK activity and regulation are common features of cancer, making CDK family members attractive targets for the development of anticancer drugs. Here, we report the identification of a pyrazolo[1,5-a]pyrimidine derived compound, 4k (BS-194), as a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9 (IC= 3, 30, 30, 250, and 90 nmol/L, respectively). Cell-based studies showed inhibition of the phosphorylation of CDK substrates, Rb and the RNA polymerase II C-terminal domain, down-regulation of cyclins A, E, and D1, and cell cycle block in the S and G/M phases. Consistent with these findings, 4k demonstrated potent antiproliferative activity in 60 cancer cell lines tested (mean GI= 280 nmol/L). Pharmacokinetic studies showed that 4k is orally bioavailable, with an elimination half-life of 178 min following oral dosing in mice. When administered at a concentration of 25 mg/kg orally, 4k inhibited human tumor xenografts and suppressed CDK substrate phosphorylation. These findings identify 4k as a novel, potent CDK selective inhibitor with potential for oral delivery in cancer patients.

Journal article

Fuchter MJ, 2010, N-Heterocyclic Carbene Mediated Activation of Tetravalent Silicon Compounds: A Critical Evaluation, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 16, Pages: 12286-12294, ISSN: 0947-6539

Journal article

Ruggiero A, Fuchter MJ, Kokas OJ, Negru M, White AJP, Haycock PR, Hoffman BM, Barrett AGMet al., 2009, A 'push-pull' tropylium-fused aminoporphyrazine, TETRAHEDRON, Vol: 65, Pages: 9690-9693, ISSN: 0040-4020

Journal article

Goslinski T, Zhong C, Fuchter MJ, White AJP, Barrett AGM, Hoffman BMet al., 2009, Serendipitous synthesis of trimetallic porphyrazine triads, TETRAHEDRON LETTERS, Vol: 50, Pages: 5178-5181, ISSN: 0040-4039

Journal article

Ali S, Heathcote DA, Kroll SHB, Jogalekar AS, Scheiper B, Patel H, Brackow J, Siwicka A, Fuchter MJ, Periyasamy M, Tolhurst RS, Kanneganti SK, Snyder JP, Liotta DC, Aboagye EO, Barrett AGM, Coombes RCet al., 2009, The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity, CANCER RESEARCH, Vol: 69, Pages: 6208-6215, ISSN: 0008-5472

Journal article

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