Imperial College London

Professor Matthew J. Fuchter

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemistry



+44 (0)20 7594 5815m.fuchter




401CMolecular Sciences Research HubWhite City Campus






BibTex format

author = {Bardell-Cox, O and White, AJP and Aragón, L and Fuchter, M},
doi = {10.1039/c9md00207c},
journal = {MedChemComm},
pages = {1438--1444},
title = {Synthetic studies on the reverse antibiotic natural products, the nybomycins},
url = {},
volume = {10},
year = {2019}

RIS format (EndNote, RefMan)

AB - Antimicrobial resistance (AMR) is a serious issue that could have severe consequences if steps are not taken. The nybomycin natural products have the potential to extend the clinical efficacy of the marketed fluoroquinolone class of antibiotics through a ‘reverse antibiotic’ approach. However, only very limited structure–activity relationships are known for these fascinating compounds, in part due to challenges with their synthesis. Here we report a new scalable and robust synthetic route to the nybomycin natural products to aid in the development of this series. Through this synthesis, we report the antibiotic activity of novel analogues of this family confirming the selectivity for fluoroquinolone resistant bacteria and potential future opportunities for further optimisation.
AU - Bardell-Cox,O
AU - White,AJP
AU - Aragón,L
AU - Fuchter,M
DO - 10.1039/c9md00207c
EP - 1444
PY - 2019///
SN - 2040-2503
SP - 1438
TI - Synthetic studies on the reverse antibiotic natural products, the nybomycins
T2 - MedChemComm
UR -
UR -!divAbstract
UR -
VL - 10
ER -