Imperial College London

Professor Matthew J. Fuchter

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemistry



+44 (0)20 7594 5815m.fuchter




401CMolecular Sciences Research HubWhite City Campus






BibTex format

author = {Scott, DJ and Fuchter, MJ and Ashley, AE},
doi = {10.1039/C7CS00154A},
journal = {Chemical Society Reviews},
pages = {5689--5700},
title = {Designing effective ‘frustrated Lewis pair’ hydrogenation catalysts},
url = {},
volume = {46},
year = {2017}

RIS format (EndNote, RefMan)

AB - The past decade has seen the subject of transition metal-free catalytic hydrogenation develop incredibly rapidly, transforming from a largely hypothetical possibility to a well-established field that can be applied to the reduction of a diverse variety of functional groups under mild conditions. This remarkable change is principally attributable to the development of so-called ‘frustrated Lewis pairs’: unquenched combinations of bulky Lewis acids and bases whose dual reactivity can be exploited for the facile activation of otherwise inert chemical bonds. While a number of comprehensive reviews into frustrated Lewis pair chemistry have been published in recent years, this tutorial review aims to provide a focused guide to the development of efficient FLP hydrogenation catalysts, through identification and consideration of the key factors that govern their effectiveness. Following discussion of these factors, their importance will be illustrated using a case study from our own research, namely the development of FLP protocols for successful hydrogenation of aldehydes and ketones, and for related moisture-tolerant hydrogenation.
AU - Scott,DJ
AU - Fuchter,MJ
AU - Ashley,AE
DO - 10.1039/C7CS00154A
EP - 5700
PY - 2017///
SN - 1460-4744
SP - 5689
TI - Designing effective ‘frustrated Lewis pair’ hydrogenation catalysts
T2 - Chemical Society Reviews
UR -
UR -
VL - 46
ER -