Imperial College London

Professor Matthew J. Fuchter

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5815m.fuchter

 
 
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Location

 

401CMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ashley:2018:10.1002/adsc.201701418,
author = {Ashley, AE and Fuchter, MJ and Tighe, C and Allcock, N and Scott, D and Sapsford, J},
doi = {10.1002/adsc.201701418},
journal = {Advanced Synthesis and Catalysis},
pages = {1066--1071},
title = {Direct reductive amination of carbonyl compounds catalyzed by a moisture tolerant Tin (IV) Lewis acid},
url = {http://dx.doi.org/10.1002/adsc.201701418},
volume = {360},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Despite the ever-broadening applications of main-group ‘frustrated Lewis pair’ (FLP) chemistry to both new and established reactions, their typical intolerance of water, especially at elevated temperatures (>100 °C), represents a key barrier to their mainstream adoption. Herein we report that FLPs based on the Lewis acid iPr3SnOTf are moisture tolerant in the presence of moderately strong nitrogenous bases, even under high temperature regimes, allowing them to operate as simple and effective catalysts for the reductive amination of organic carbonyls, including for challenging bulky amine and carbonyl substrate partners.
AU - Ashley,AE
AU - Fuchter,MJ
AU - Tighe,C
AU - Allcock,N
AU - Scott,D
AU - Sapsford,J
DO - 10.1002/adsc.201701418
EP - 1071
PY - 2018///
SN - 1615-4150
SP - 1066
TI - Direct reductive amination of carbonyl compounds catalyzed by a moisture tolerant Tin (IV) Lewis acid
T2 - Advanced Synthesis and Catalysis
UR - http://dx.doi.org/10.1002/adsc.201701418
UR - http://hdl.handle.net/10044/1/55349
VL - 360
ER -