Imperial College London

Professor Matthew J. Fuchter

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5815m.fuchter

 
 
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Location

 

401CMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

105 results found

Gibson R, Calbo J, Fuchter MJ, Chemical Z‐E isomer switching of arylazopyrazoles using acid, ChemPhotoChem, ISSN: 2367-0932

JOURNAL ARTICLE

Yahiya S, Rueda-Zubiaurre A, Delves MJ, Fuchter MJ, Baum Jet al., 2019, The antimalarial screening landscape-looking beyond the asexual blood stage., Curr Opin Chem Biol, Vol: 50, Pages: 1-9

In recent years, the research agenda to tackle global morbidity and mortality from malaria disease has shifted towards innovation, in the hope that efforts at the frontiers of scientific research may re-invigorate gains made towards eradication. Discovery of new antimalarial drugs with novel chemotypes or modes of action lie at the heart of these efforts. There is a particular interest in drug candidates that target stages of the malaria parasite lifecycle beyond the symptomatic asexual blood stages. This is especially important given the spectre of emerging drug resistance to all current frontline antimalarials. One approach gaining increased interest is the potential of designing novel drugs that target parasite passage from infected individual to feeding mosquito and back again. Action of such therapeutics is geared much more at the population level rather than just concerned with the infected individual. The search for novel drugs active against these stages has been helped by improvements to in vitro culture of transmission and pre-erythrocytic parasite lifecycle stages, robotic automation and high content imaging, methodologies that permit the high-throughput screening (HTS) of compound libraries for drug discovery. Here, we review recent advances in the antimalarial screening landscape, focussed on transmission blocking as a key aim for drug-treatment campaigns of the future.

JOURNAL ARTICLE

Salerno F, Rice B, Schmidt JA, Fuchter MJ, Nelson J, Jelfs KEet al., 2019, The influence of nitrogen position on charge carrier mobility in enantiopure aza[6]helicene crystals, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 21, Pages: 5059-5067, ISSN: 1463-9076

JOURNAL ARTICLE

Chavas TEJ, Fuchter MJ, DiMaggio PA, 2018, Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides, ACS CHEMICAL BIOLOGY, Vol: 13, Pages: 2897-2907, ISSN: 1554-8929

JOURNAL ARTICLE

Delves MJ, Miguel-Blanco C, Matthews H, Molina I, Ruecker A, Yahiya S, Straschil U, Abraham M, Luisa Leon M, Fischer OJ, Rueda-Zubiaurre A, Brandt JR, Cortes A, Barnard A, Fuchter MJ, Calderon F, Winzeler EA, Sinden RE, Herreros E, Gamo FJ, Baum Jet al., 2018, A high throughput screen for next-generation leads targeting malaria parasite transmission, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723

JOURNAL ARTICLE

Fuchter MJ, 2018, Editorial, BIOORGANIC & MEDICINAL CHEMISTRY, Vol: 26, Pages: 2919-2920, ISSN: 0968-0896

JOURNAL ARTICLE

Yang Y, Rice B, Shi X, Brandt JR, da Costa RC, Hedley GJ, Smilgies D-M, Frost JM, Samuel IDW, Otero-de-la-Roza A, Johnson ER, Jelfs KE, Nelson J, Campbell AJ, Fuchter MJet al., 2018, Emergent Properties of an Organic Semiconductor Driven by its Molecular Chirality (vol 11, pg 8329, 2017), ACS NANO, Vol: 12, Pages: 6343-6343, ISSN: 1936-0851

JOURNAL ARTICLE

Patel H, Periyasamy M, Sava GP, Bondke A, Slafer BW, Kroll SHB, Barbazanges M, Starkey R, Ottaviani S, Harrod A, Aboagye EO, Buluwela L, Fuchter MJ, Barrett AGM, Coombes RC, Ali Set al., 2018, ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment, MOLECULAR CANCER THERAPEUTICS, Vol: 17, Pages: 1156-1166, ISSN: 1535-7163

JOURNAL ARTICLE

Rice B, LeBlanc LM, Otero-de-la-Roza A, Fuchter MJ, Johnson ER, Nelson J, Jelfs KEet al., 2018, A computational exploration of the crystal energy and charge-carrier mobility landscapes of the chiral [6]helicene molecule (vol 10, pg 1865, 2018), NANOSCALE, Vol: 10, Pages: 9410-9410, ISSN: 2040-3364

JOURNAL ARTICLE

Lubin AS, Rueda-Zubiaurre A, Matthews H, Baumann H, Fisher FR, Morales-Sanfrutos J, Hadayizadeh KS, Nardella F, Tate EW, Baum J, Scherf A, Fuchter MJet al., 2018, Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum, ACS INFECTIOUS DISEASES, Vol: 4, Pages: 523-530, ISSN: 2373-8227

JOURNAL ARTICLE

Sapsford JS, Scott DJ, Allcock NJ, Fuchter MJ, Tighe CJ, Ashley AEet al., 2018, Direct Reductive Amination of Carbonyl Compounds Catalyzed by a Moisture Tolerant Tin(IV) Lewis Acid, ADVANCED SYNTHESIS & CATALYSIS, Vol: 360, Pages: 1066-1071, ISSN: 1615-4150

JOURNAL ARTICLE

Rice B, LeBlanc LM, Otero-de-la-Roza A, Fuchter MJ, Johnson ER, Nelson J, Jelfs KEet al., 2018, A computational exploration of the crystal energy and charge-carrier mobility landscapes of the chiral [6] helicene molecule, NANOSCALE, Vol: 10, Pages: 1865-1876, ISSN: 2040-3364

JOURNAL ARTICLE

Hazel P, Kroll SHB, Bondke A, Barbazanges M, Patel H, Fuchter MJ, Coombes RC, Ali S, Barrett AGM, Freemont PSet al., 2018, Inhibitor Selectivity for Cyclin-Dependent Kinase7: A Structural, Thermodynamic, and Modelling Study (vol 12, pg 372, 2017), CHEMMEDCHEM, Vol: 13, Pages: 207-207, ISSN: 1860-7179

JOURNAL ARTICLE

Montgomery KS, Davidson RWM, Cao B, Williams B, Simpson GW, Nilsson SK, Chiefari J, Fuchter MJet al., 2018, Effective macrophage delivery using RAFT copolymer derived nanoparticles, POLYMER CHEMISTRY, Vol: 9, Pages: 131-137, ISSN: 1759-9954

JOURNAL ARTICLE

Scott DJ, Fuchter MJ, Ashley AE, 2017, Designing effective 'frustrated Lewis pair' hydrogenation catalysts, CHEMICAL SOCIETY REVIEWS, Vol: 46, Pages: 5689-5700, ISSN: 0306-0012

JOURNAL ARTICLE

Brandt JR, Pospisil L, Bednarova L, da Costa RC, White AJP, Mori T, Teply F, Fuchter MJet al., 2017, Intense redox-driven chiroptical switching with a 580 mV hysteresis actuated through reversible dimerization of an azoniahelicene, CHEMICAL COMMUNICATIONS, Vol: 53, Pages: 9059-9062, ISSN: 1359-7345

JOURNAL ARTICLE

Yang Y, Rice B, Shi X, Brandt JR, Correa da Costa R, Hedley GJ, Smilgies D-M, Frost JM, Samuel IDW, Otero-de-la-Roza A, Johnson ER, Jelfs KE, Nelson J, Campbell AJ, Fuchter MJet al., 2017, Emergent Properties of an Organic Semiconductor Driven by its Molecular Chirality, ACS Nano, Vol: 11, Pages: 8329-8338, ISSN: 1936-0851

Chiral molecules exist as pairs of nonsuperimposable mirror images; a fundamental symmetry property vastly underexplored in organic electronic devices. Here, we show that organic field-effect transistors (OFETs) made from the helically chiral molecule 1-aza[6]helicene can display up to an 80-fold difference in hole mobility, together with differences in thin-film photophysics and morphology, solely depending on whether a single handedness or a 1:1 mixture of left- and right-handed molecules is employed under analogous fabrication conditions. As the molecular properties of either mirror image isomer are identical, these changes must be a result of the different bulk packing induced by chiral composition. Such underlying structures are investigated using crystal structure prediction, a computational methodology rarely applied to molecular materials, and linked to the difference in charge transport. These results illustrate that chirality may be used as a key tuning parameter in future device applications.

JOURNAL ARTICLE

Brandt JR, Salerno F, Fuchter MJ, 2017, The added value of small-molecule chirality in technological applications, NATURE REVIEWS CHEMISTRY, Vol: 1, ISSN: 2397-3358

JOURNAL ARTICLE

Sundriyal S, Chen PB, Lubin AS, Lueg GA, Li F, White AJP, Malmquist NA, Vedadi M, Scherf A, Fuchter MJet al., 2017, Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity, MEDCHEMCOMM, Vol: 8, Pages: 1069-1092, ISSN: 2040-2503

JOURNAL ARTICLE

Hazel P, Kroll SHB, Bondke A, Barbazanges M, Patel H, Fuchter MJ, Coombes RC, Ali S, Barrett AGM, Freemont PSet al., 2017, Inhibitor Selectivity for Cyclin-Dependent Kinase7: AStructural, Thermodynamic, and Modelling Study, CHEMMEDCHEM, Vol: 12, Pages: 372-380, ISSN: 1860-7179

JOURNAL ARTICLE

Weston CE, Kraemer A, Colin F, Yildiz O, Baud MGJ, Meyer-Almes F-J, Fuchter MJet al., 2017, Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors, ACS INFECTIOUS DISEASES, Vol: 3, Pages: 152-161, ISSN: 2373-8227

JOURNAL ARTICLE

Sundriyal S, Moniot S, Mahmud Z, Yao S, Di Fruscia P, Reynolds CR, Dexter DT, Sternberg MJ, Lam EW, Steegborn C, Fuchter MJet al., 2017, Thienopyrimidinone based sirtuin-2 (SIRT2)-selective inhibitors bind in the ligand induced 'selectivity pocket'., Journal of Medicinal Chemistry, Vol: 60, Pages: 1928-1945, ISSN: 0022-2623

Sirtuins (SIRTs) are NAD-dependent deacylases, known to be involved in a variety of pathophysiological processes and thus remain promising therapeutic targets for further validation. Previously, we reported a novel thienopyrimidinone SIRT2 inhibitor with good potency and excellent selectivity for SIRT2. Herein, we report an extensive SAR study of this chemical series and identify the key pharmacophoric elements and physiochemical properties that underpin the excellent activity observed. New analogues have been identified with submicromolar SIRT2 inhibtory activity and good to excellent SIRT2 subtype-selectivity. Importantly, we report a co-crystal structure of one of our compounds (29c) bound to SIRT2. This reveals our series to induce the formation of a previously reported 'selectivity pocket', but to bind in an inverted fashion to what might be intuitively expected. We believe these findings will contribute significantly to understanding of the mechanism of action of SIRT2 inhibitors and to the identification of refined, second generation inhibitors.

JOURNAL ARTICLE

Calbo J, Weston CE, White AJP, Rzepa HS, Contreras-Garcia J, Fuchter MJet al., 2017, Tuning Azoheteroarene Photoswitch Performance through Heteroaryl Design, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 139, Pages: 1261-1274, ISSN: 0002-7863

JOURNAL ARTICLE

Scott DJ, Phillips NA, Sapsford JS, Deacy AC, Fuchter MJ, Ashley AEet al., 2016, Versatile Catalytic Hydrogenation Using A Simple Tin(IV) Lewis Acid, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 55, Pages: 14738-14742, ISSN: 1433-7851

JOURNAL ARTICLE

Davidson RWM, Fuchter MJ, 2016, Direct NHC-catalysed redox amidation using CO2 for traceless masking of amine nucleophiles, CHEMICAL COMMUNICATIONS, Vol: 52, Pages: 11638-11641, ISSN: 1359-7345

JOURNAL ARTICLE

Weston CE, Richardson RD, Haycock PR, White AJP, Fuchter MJet al., 2016, "Arylazopyrazoles: Azoheteroarene Photoswitches Offering Quantitative Isomerization and Long Thermal Half-Lives (vol 136, pg 11878, 2014), JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 138, Pages: 10716-10716, ISSN: 0002-7863

JOURNAL ARTICLE

Ali S, Patel H, Periyasamy M, Bondke A, Slafer BW, Ottaviani S, Harrod A, Buluwela L, Fuchter MJ, Barrett AGM, Coombes RCet al., 2016, ICEC0942, an orally bioavailable selective inhibitor of CDK7 for breast cancer, UK Breast Cancer Research Symposium, Publisher: Springer Verlag, Pages: 195-195, ISSN: 0167-6806

CONFERENCE PAPER

Brandt JR, Wang X, Yang Y, Campbell AJ, Fuchter MJet al., 2016, Circularly Polarized Phosphorescent Electroluminescence with a High Dissymmetry Factor from PHOLEDs Based on a Platinahelicene, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 138, Pages: 9743-9746, ISSN: 0002-7863

JOURNAL ARTICLE

Chen PB, Ding S, Zanghi G, Soulard V, DiMaggio PA, Fuchter MJ, Mecheri S, Mazier D, Scherf A, Malmquist NAet al., 2016, Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

Weston CE, Richardson RD, Fuchter MJ, 2016, Photoswitchable basicity through the use of azoheteroarenes, CHEMICAL COMMUNICATIONS, Vol: 52, Pages: 4521-4524, ISSN: 1359-7345

JOURNAL ARTICLE

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