Imperial College London
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Professor Matthew J. Fuchter

Faculty of Natural Sciences, Department of Chemistry

Professor of Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5815m.fuchter

 
 
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Location

 

110DMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rushworth:2020:10.1021/acsabm.0c00529,
author = {Rushworth, J and Montgomery, K and Cao, B and Brown, R and Dibb, N and Nilsson, SK and Chiefari, J and Fuchter, MJ},
doi = {10.1021/acsabm.0c00529},
journal = {ACS Applied Bio Materials},
pages = {5775--5786},
title = {Glycosylated nanoparticles derived from RAFT polymerization for effective drug delivery to macrophages},
url = {http://dx.doi.org/10.1021/acsabm.0c00529},
volume = {3},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The functional group tolerance and simplicity of reversible addition fragmentation chain transfer (RAFT) polymerization enable its use in the preparation of a wide range of functional polymer architectures for a variety of applications, including drug delivery. Given the role of tumor-associated macrophages (TAMs) in cancer and their dependence on the tyrosine kinase receptor FMS (CSF-1R), the key aim of this work was to achieve effective delivery of an FMS inhibitor to cells using a polymer delivery system. Such a system has the potential to exploit biological features specific to macrophages and therefore provide enhanced selectivity. Building on our prior work, we have prepared RAFT polymers based on a poly(butyl methacrylate-co-methacrylic acid) diblock, which were extended with a hydrophilic block, a cross-linker, and a mannose-based monomer scaffold, exploiting the abundance of macrophage mannose receptors (MMRs, CD206) on the surface of macrophages. We demonstrate that the prepared polymers can be assembled into nanoparticles and are successfully internalized into macrophages, in part, via the MMR (CD206). Finally, we showcase the developed nanoparticles in the delivery of an FMS inhibitor to cells, resulting in inhibition of the FMS receptor. As such, this study lays the groundwork for further drug-delivery studies aimed at specifically targeting TAMs with molecularly targeted therapeutics.
AU  - Rushworth,J
AU  - Montgomery,K
AU  - Cao,B
AU  - Brown,R
AU  - Dibb,N
AU  - Nilsson,SK
AU  - Chiefari,J
AU  - Fuchter,MJ
DO  - 10.1021/acsabm.0c00529
EP  - 5786
PY  - 2020///
SN  - 2576-6422
SP  - 5775
TI  - Glycosylated nanoparticles derived from RAFT polymerization for effective drug delivery to macrophages
T2  - ACS Applied Bio Materials
UR  - http://dx.doi.org/10.1021/acsabm.0c00529
UR  - https://pubs.acs.org/doi/10.1021/acsabm.0c00529
UR  - http://hdl.handle.net/10044/1/81702
VL  - 3
ER  -
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