Imperial College London
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Professor Matthew J. Fuchter

Faculty of Natural Sciences, Department of Chemistry

Professor of Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5815m.fuchter

 
 
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Location

 

110DMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Montgomery:2017:10.1039/c7py01363a,
author = {Montgomery, KS and Davidson, RWM and Cao, B and Williams, B and Simpson, GW and Nilsson, SK and Chiefari, J and Fuchter, MJ},
doi = {10.1039/c7py01363a},
journal = {Polymer Chemistry},
pages = {131--137},
title = {Effective macrophage delivery using RAFT copolymer derived nanoparticles},
url = {http://dx.doi.org/10.1039/c7py01363a},
volume = {9},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Reversible addition fragmentation chain transfer (RAFT) polymerisation provides a highly controlled means to assemble copolymers of different architectures for a variety of applications, including drug delivery. Polymers consisting of a butyl methacrylate-co-methacrylic acid p(BMA-co-MAA) hydrophobic block and a poly(ethylene glycol) methyl ether methacrylate p(PEGMA-475) hydrophilic block were synthesised via RAFT polymerisation and self-assembled into micelles. A range of micelle particles of different sizes were obtained by varying the composition of the block copolymers. The micelles were crosslinked to form nanoparticles and fluorescently labelled to study cellular internalisation. The prepared nanoparticles were extensively taken up by primary murine macrophages and a promising candidate was identified. To demonstrate effective delivery of a cell impenetrable cargo a fluorescent dye, 4′,6-diamidino-2-phenylindole (DAPI), was encapsulated inside the nanoparticles and successfully delivered to macrophages. The nanoparticles’ stability at increased temperatures and at low concentrations, the tunability of their synthesis and their extensive internalisation by macrophages and performance makes them highly promising delivery vehicles for a range of therapeutics and imaging agents.
AU  - Montgomery,KS
AU  - Davidson,RWM
AU  - Cao,B
AU  - Williams,B
AU  - Simpson,GW
AU  - Nilsson,SK
AU  - Chiefari,J
AU  - Fuchter,MJ
DO  - 10.1039/c7py01363a
EP  - 137
PY  - 2017///
SN  - 1759-9954
SP  - 131
TI  - Effective macrophage delivery using RAFT copolymer derived nanoparticles
T2  - Polymer Chemistry
UR  - http://dx.doi.org/10.1039/c7py01363a
UR  - http://hdl.handle.net/10044/1/55799
VL  - 9
ER  -
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