Imperial College London

ProfessorMichaelGatzoulis

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 2723m.gatzoulis

 
 
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Location

 

, CardiobiologyChelsea WingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

420 results found

Blanche C, Alonso-Gonzalez R, Uribarri A, Kempny A, Swan L, Price L, Wort SJ, Beghetti M, Dimopoulos Ket al., 2018, Use of intravenous iron in cyanotic patients with congenital heart disease and/or pulmonary hypertension, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: ELSEVIER IRELAND LTD, Pages: 79-83, ISSN: 0167-5273

Conference paper

Tutarel O, Alonso-Gonzalez R, Montanaro C, Schiff R, Uribarri A, Kempny A, Grubler MR, Uebing A, Swan L, Diller G-P, Dimopoulos K, Gatzoulis MAet al., 2018, Infective endocarditis in adults with congenital heart disease remains a lethal disease, Congress of the European-Society-of-Cardiology (ESC), Publisher: BMJ PUBLISHING GROUP, Pages: 161-+, ISSN: 1355-6037

Conference paper

Boutsikou M, Uebing A, Kilner P, Li W, Kempny A, Gatzoulis MAet al., 2015, Brock procedure: 52 years of effective palliation for Tetralogy of Fallot, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 199, Pages: 195-196, ISSN: 0167-5273

Journal article

Wald RM, Valente AM, Gauvreau K, Babu-Narayan SV, Assenza GE, Schreier J, Gatzoulis MA, Kilner PJ, Koyak Z, Mulder B, Powell AJ, Geva Tet al., 2015, Cardiac magnetic resonance markers of progressive RV dilation and dysfunction after tetralogy of Fallot repair, HEART, Vol: 101, Pages: 1724-1730, ISSN: 1355-6037

Journal article

Heng EL, Gatzoulis MA, Babu-Narayan SV, 2015, Tailoring counselling after pulmonary valve surgery in repaired tetralogy of Fallot, HEART, Vol: 101, Pages: 1695-1696, ISSN: 1355-6037

Journal article

Gelson E, Curry R, Gatzoulis MA, Swan L, Lupton M, Steer PJ, Johnson MRet al., 2015, Maternal cardiac and obstetric performance in consecutive pregnancies in women with heart disease, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 122, Pages: 1552-1559, ISSN: 1470-0328

Journal article

Babu-Narayan SV, Giannakoulas G, Valente AM, Li W, Gatzoulis MAet al., 2015, Imaging of congenital heart disease in adults., European Heart Journal, Vol: 37, Pages: 1182-1195, ISSN: 1522-9645

Imaging is fundamental to the lifelong care of adult congenital heart disease (ACHD) patients. Echocardiography remains the first line imaging for inpatient, outpatient, or perioperative care. Cross-sectional imaging with cardiovascular magnetic resonance (CMR) or computed tomography (CT) provides complementary and invaluable information on cardiac and vascular anatomy and other intra-thoracic structures. Furthermore, CMR provides quantification of cardiac function and vascular flow. Cardiac catheterization is mostly reserved for assessment of pulmonary vascular resistance, ventricular end-diastolic pressure, and percutaneous interventions. There have been further advances in non-invasive imaging for ACHD including the application of advanced echocardiographic techniques, faster automated CMR imaging, and radiation dose reduction in CT. As a result ACHD, a heterogeneous population, benefit from appropriate application of multiple imaging modalities matched with tertiary ACHD expertise.

Journal article

Orwat MI, Kempny A, Bauer U, Gatzoulis MA, Baumgartner H, Diller G-Pet al., 2015, The importance of national and international collaboration in adult congenital heart disease: A network analysis of research output, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 195, Pages: 155-162, ISSN: 0167-5273

Journal article

Diller G-P, Kempny A, Alonso-Gonzalez R, Swan L, Uebing A, Li W, Babu-Narayan S, Wort SJ, Dimopoulos K, Gatzoulis MAet al., 2015, Survival prospects and circumstances of death in contemporary adult congenital heart disease patients under follow-up at a large tertiary centre, Circulation, Vol: 132, Pages: 2118-2125, ISSN: 0009-7322

Background—Adult congenital heart disease (ACHD) patients have ongoing morbidity and reduced long-term survival. Recently, the importance of specialized follow-up at tertiary ACHD centers has been highlighted. We aimed to assess survival prospects and clarify causes of death in a large cohort of patients at a single, tertiary center.Methods and Results—We included 6969 adult patients (age 29.9±15.4 years) under follow-up at our institution between 1991 and 2013. Causes of death were ascertained from official death certificates. Survival was compared with the expected survival in the general age- and sex-matched population, and standardized mortality rates were calculated. Over a median follow-up time of 9.1 years (interquartile range, 5.2–14.5), 524 patients died. Leading causes of death were chronic heart failure (42%), pneumonia (10%), sudden-cardiac death (7%), cancer (6%), and hemorrhage (5%), whereas perioperative mortality was comparatively low. Isolated simple defects exhibited mortality rates similar to those in the general population, whereas patients with Eisenmenger syndrome, complex congenital heart disease, and Fontan physiology had much poorer long-term survival (P<0.0001 for all). The probability of cardiac death decreased with increasing patient’s age, whereas the proportion of patients dying from noncardiac causes, such as cancer, increased.Conclusions—ACHD patients continue to be afflicted by increased mortality in comparision with the general population as they grow older. Highest mortality rates were observed among patients with complex ACHD, Fontan physiology, and Eisenmenger syndrome. Our data provide an overview over causes of mortality and especially the spectrum of noncardiac causes of death in contemporary ACHD patients.

Journal article

Diller G-P, Braeutigam A, Kempny A, Uebing A, Alonso-Gonzalez R, Swan L, Babu-Narayan SV, Baumgartner H, Dimopoulos K, Gatzoulis AAet al., 2015, Depression requiring anti-depressant drug therapy in adult congenital heart disease: prevalence, risk factors, and prognostic value, European Heart Journal, Vol: 37, Pages: 771-782, ISSN: 1522-9645

Background Depression is prevalent in adults with congenital heart disease (ACHD), but limited data on the frequency of anti-depressant drug (ADD) therapy and its impact on outcome are available.Methods and results We identified all ACHD patients treated with ADDs between 2000 and 2011 at our centre. Of 6162 patients under follow-up, 204 (3.3%) patients were on ADD therapy. The majority of patients were treated with selective serotonin-reuptake inhibitors (67.4%), while only 17.0% of patients received tricyclic anti-depressants. Twice as many female patients used ADDs compared with males (4.4 vs. 2.2%, P < 0.0001). The percentage of patients on ADDs increased with disease complexity (P < 0.0001) and patient age (P < 0.0001). Over a median follow-up of 11.1 years, 507 (8.2%) patients died. After propensity score matching, ADD use was found to be significantly associated with worse outcome in male ACHD patients [hazard ratio 1.44 (95% confidence interval 1.17–1.84)]. There was no evidence that this excess mortality was directly related to ADD therapy, QT-prolongation, or malignant arrhythmias. However, males taking ADDs were also more likely to miss scheduled follow-up appointments compared with untreated counterparts, while no such difference in clinic attendance was seen in females.Conclusions The use of ADD therapy in ACHD relates to gender, age, and disease complexity. Although, twice as many female patients were on ADDs, it were their male counterparts, who were at increased mortality risk on therapy. Furthermore, males on ADDs had worse adherence to scheduled appointments suggesting the need for special medical attention and possibly psychosocial intervention for this group of patients.

Journal article

Rydman R, Gatzoulis MA, Ho SY, Ernst S, Swan L, Li W, Wong T, Sheppard M, McCarthy KP, Roughton M, Kilner PJ, Pennell DJ, Babu-Narayan SVet al., 2015, Systemic Right Ventricular Fibrosis Detected by Cardiovascular Magnetic Resonance Is Associated With Clinical Outcome, Mainly New-Onset Atrial Arrhythmia, in Patients After Atrial Redirection Surgery for Transposition of the Great Arteries, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 8, ISSN: 1941-9651

Journal article

Di Mario C, Kilic ID, Yeh JSM, Pighi M, Serdoz R, Gatzoulis MA, Dimopoulos Ket al., 2015, Exclusion of a giant aneurysm post-Kawasaki disease with novel polyurethane covered stents, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 184, Pages: 664-666, ISSN: 0167-5273

Journal article

Heng EL, Bolger AP, Kempny A, Davlouros PA, Davidson S, Swan L, Uebing A, Pennell DJ, Gatzoulis MA, Babu-Narayan SVet al., 2015, Neurohormonal activation and its relation to outcomes late after repair of tetralogy of Fallot, HEART, Vol: 101, Pages: 447-454, ISSN: 1355-6037

Journal article

Kempny A, Diller G-P, Alonso-Gonzalez R, Uebing A, Rafiq I, Li W, Swan L, Hooper J, Donovan J, Wort SJ, Gatzoulis MA, Dimopoulos Ket al., 2015, Hypoalbuminaemia predicts outcome in adult patients with congenital heart disease, Heart, Vol: 101, Pages: 699-705, ISSN: 1355-6037

Background In patients with acquired heart failure, hypoalbuminaemia is associated with increased risk of death. The prevalence of hypoproteinaemia and hypoalbuminaemia and their relation to outcome in adult patients with congenital heart disease (ACHD) remains, however, unknown.Methods Data on patients with ACHD who underwent blood testing in our centre within the last 14 years were collected. The relation between laboratory, clinical or demographic parameters at baseline and mortality was assessed using Cox proportional hazards regression analysis.Results A total of 2886 patients with ACHD were included. Mean age was 33.3 years (23.6–44.7) and 50.1% patients were men. Median plasma albumin concentration was 41.0 g/L (38.0–44.0), whereas hypoalbuminaemia (<35 g/L) was present in 13.9% of patients. The prevalence of hypoalbuminaemia was significantly higher in patients with great complexity ACHD (18.2%) compared with patients with moderate (11.3%) or simple ACHD lesions (12.1%, p<0.001). During a median follow-up of 5.7 years (3.3–9.6), 327 (11.3%) patients died. On univariable Cox regression analysis, hypoalbuminaemia was a strong predictor of outcome (HR 3.37, 95% CI 2.67 to 4.25, p<0.0001). On multivariable Cox regression, after adjusting for age, sodium and creatinine concentration, liver dysfunction, functional class and disease complexity, hypoalbuminaemia remained a significant predictor of death.Conclusions Hypoalbuminaemia is common in patients with ACHD and is associated with a threefold increased risk of risk of death. Hypoalbuminaemia, therefore, should be included in risk-stratification algorithms as it may assist management decisions and timing of interventions in the growing ACHD population.

Journal article

Bedair R, Babu-Narayan SV, Dimopoulos K, Quyam S, Doyle A-M, Swan L, Gatzoulis MA, Wong Tet al., 2015, Acceptance and psychological impact of implantable defibrillators amongst adults with congenital heart disease, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 181, Pages: 218-224, ISSN: 0167-5273

Journal article

Moceri P, Kempny A, Liodakis E, Gonzales RA, Germanakis I, Diller G-P, Swana L, Marino PS, Wort SJ, Babu-Narayan SV, Ferrari E, Gatzoulis MA, Li W, Dimopoulos Ket al., 2015, Physiological differences between various types of Eisenmenger syndrome and relation to outcome, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 179, Pages: 455-460, ISSN: 0167-5273

Journal article

Gatzoulis MA, Beghetti M, Landzberg MJ, Galie Net al., 2014, Pulmonary arterial hypertension associated with congenital heart disease: Recent advances and future directions, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 177, Pages: 340-347, ISSN: 0167-5273

Journal article

Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, Gomez Sanchez MA, Kumar RK, Landzberg M, Machado RF, Olschewski H, Robbins IM, Souza Ret al., 2014, [Updated clinical classification of pulmonary hypertension]., Turk Kardiyol Dern Ars, Vol: 42 Suppl 1, Pages: 45-54, ISSN: 1016-5169

In 1998, a clinical classification of pulmonary hypertension (PH) was established, categorizing PH into groups which share similar pathological and hemodynamic characteristics and therapeutic approaches. During the 5th World Symposium held in Nice, France, in 2013, the consensus was reached to maintain the general scheme of previous clinical classifications. However, modifications and updates especially for Group 1 patients (pulmonary arterial hypertension [PAH]) were proposed. The main change was to withdraw persistent pulmonary hypertension of the newborn (YPPH) from Group 1 because this entity carries more differences than similarities with other PAH subgroups. In the current classification, PPHN is now designated number 1". Pulmonary hypertension associated with chronic hemolytic anemia has been moved from Group 1 PAH to Group 5, unclear/multifactorial mechanism. In addition, it was decided to add specific items related to pediatric pulmonary hypertension in order to create a comprehensive, common classification for both adults and children. Therefore, congenital or acquired left-heart inflow/outflow obstructive lesions and congenital cardiomyopathies have been added to Group 2, and segmental pulmonary hypertension has been added to Group 5. Last, there were no changes for Groups 2, 3, and 4. (J Am Coll Cardiol 2013;62:D34-41) a 2013 by the American College of Cardiology Foundation.

Journal article

Kempny A, Diller GP, Dimopoulos K, Alonso-Gonzalez R, Uebing A, Li W, Babu-Narayan S, Swan L, Wort SJ, Gatzoulis MAet al., 2014, Attendance of outpatient clinic appointments amongst adults with congenital heart disease: predictors and relation to outcome, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 517-518, ISSN: 0195-668X

Conference paper

Kempny A, Diller GP, Alonso-Gonzalez R, Uebing A, Li W, Swan L, Wort SJ, Gatzoulis MA, Dimopoulos Ket al., 2014, Hypoalbuminemia predicts outcome in adult patients with congenital heart disease, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 516-516, ISSN: 0195-668X

Conference paper

Diller GP, Braeutigam A, Kempny A, Uebing A, Dimopoulos K, Swan L, Baumgartner H, Gatzoulis MAet al., 2014, Depressive symptoms requiring antidepressant drug therapy in adult congenital heart disease, relate to gender and disease severity and are independently associated with higher mortality, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 517-517, ISSN: 0195-668X

Conference paper

Radke RM, Giardini A, Buys R, Kohalmi D, Cervi E, Alam S, Gatzoulis MA, Budts W, Diller GP, Hager Aet al., 2014, Predicting survival of patients with cyanotic congenital heart disease: The value of cardiopulmonary exercise testing. Results from an international multicentre study, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 517-517, ISSN: 0195-668X

Conference paper

Diller GP, Kempny A, Inuzuka R, Radke R, Gatzoulis MA, Baumgartner H, Dimopoulos Ket al., 2014, Poor survival prospects of treatment naive Eisenmenger patients in the current era - a systematic review and report of own experience, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 44-44, ISSN: 0195-668X

Conference paper

Scognamiglio G, Kempny A, Price LC, Alonso-Gonzalez R, Marino P, Swan L, D'Alto M, Hooper J, Gatzoulis MA, Dimopoulos K, Wort SJet al., 2014, C-reactive protein in adults with pulmonary arterial hypertension associated with congenital heart disease and its prognostic value, HEART, Vol: 100, Pages: 1335-1341, ISSN: 1355-6037

Journal article

Diller G-P, Kempny A, Inuzuka R, Radke R, Wort SJ, Baumgartner H, Gatzoulis MA, Dimopoulos Ket al., 2014, Survival prospects of treatment naive patients with Eisenmenger: a systematic review of the literature and report of own experience, HEART, Vol: 100, Pages: 1366-1372, ISSN: 1355-6037

Journal article

Kempny A, Dimopoulos K, Gatzoulis MA, 2014, Single-ventricle physiology in the UK: an ongoing challenge of growing numbers and of growing complexity of congenital heart disease, HEART, Vol: 100, Pages: 1315-1316, ISSN: 1355-6037

Journal article

Corte TJ, Keir GJ, Dimopoulos K, Howard L, Corris PA, Parfitt L, Foley C, Yanez-Lopez M, Babalis D, Marino P, Maher TM, Renzoni EA, Spencer L, Elliot CA, Birring SS, O'Reilly K, Gatzoulis MA, Wells AU, Wort SJet al., 2014, Bosentan in Pulmonary Hypertension Associated with Fibrotic Idiopathic Interstitial Pneumonia, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 190, Pages: 208-217, ISSN: 1073-449X

Journal article

Prapa S, Mccarthy KP, Krexi D, Gatzoulis MA, Ho SYet al., 2014, The aortic root phenotype in bicuspid aortic valve disease: evidence of shared Smad2 activation in aortic regions of distinct embryologic origin, 3rd Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology, Publisher: OXFORD UNIV PRESS, ISSN: 0008-6363

Conference paper

Kahr PC, Alonso-Gonzalez R, Kempny A, Orwat S, Uebing A, Dimopoulos K, Swan L, Baumgartner H, Gatzoulis MA, Diller G-Pet al., 2014, Long-term natural history and postoperative outcome of double-chambered right ventricle-Experience from two tertiary adult congenital heart centres and review of the literature, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 174, Pages: 662-668, ISSN: 0167-5273

Journal article

Giannakoulas G, Mouratoglou S-A, Gatzoulis MA, Karvounis Het al., 2014, Blood biomarkers and their potential role in pulmonary arterial hypertension associated with congenital heart disease. A systematic review, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 174, Pages: 618-623, ISSN: 0167-5273

Journal article

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