Honorary Principal Research Fellow at the National Heart and Lung Institute and Consultant Physician at St Bartholomew's Hospital, London. Having qualified at London University in 1987, he was appointed as a consultant in 2001.
Clinical interests include ARDS, ICU acquired weakness, human models of ARDS and other aspects of critical illness, and extra-corporeal gas exchange techniques.
His research is focussed on cellular and molecular mechanisms of acute lung injury and repair. Current, focus of research is the effect of mechanical forces on lung injury and repair; current models include cellular stretch, in vivo murine ventilator-induced lung injury (with Prof Takata, SORA ICL), EVLP and surgical models of acute lung injury and multiple organ dysfunction. He is involved in multidisciplinary translational research which integrates basic science with clinical studies, thereby providing novel insights into critical illness.
et al., 2017, Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema, Thorax, Vol:72, ISSN:0040-6376, Pages:510-521
et al., 2017, pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure., J Intensive Care Soc, Vol:18, ISSN:1751-1437, Pages:159-169
et al., 2017, Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair, Disease Models & Mechanisms, Vol:10, ISSN:1754-8403, Pages:409-423
et al., 2017, miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting., J Cachexia Sarcopenia Muscle
et al., 2017, Surfactant Metabolism During Normothermic Ex Vivo Lung Perfusion, 37th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation (ISHLT), ELSEVIER SCIENCE INC, Pages:S91-S91, ISSN:1053-2498