Imperial College London

Mark Griffiths

Faculty of MedicineNational Heart & Lung Institute

Professor of Critical Care Medicine



m.griffiths Website




363Sir Alexander Fleming BuildingSouth Kensington Campus





Professor of Critical Care Medicine at the National Heart and Lung Institute and Consultant Physician at St Bartholomew's Hospital, London. Having qualified at London University in 1987, he was appointed as a consultant in 2002.

Clinical interests include ARDS, ICU acquired weakness, human models of ARDS and other aspects of critical illness, and extra-corporeal gas exchange techniques. 

His research is focussed on cellular and molecular mechanisms of acute lung injury and repair. Current, focus of research is the effect of mechanical forces on lung injury and repair; current models include cellular stretch, in vivo murine ventilator-induced lung injury (with Prof Takata, SORA ICL), EVLP and surgical models of acute lung injury and multiple organ dysfunction. He is involved in multidisciplinary translational research which integrates basic science with clinical studies, thereby providing novel insights into critical illness.



Proudfoot A, Bayliffe A, O'Kane CM, et al., 2018, Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury, Thorax, Vol:73, ISSN:0040-6376, Pages:723-730

Dunning J, Blankley S, Hoang LT, et al., 2018, Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza, Nature Immunology, Vol:19, ISSN:1529-2908, Pages:625-+

Connolly M, Paul R, Farre-Garros R, et al., 2018, miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting, Journal of Cachexia Sarcopenia and Muscle, Vol:9, ISSN:2190-6009, Pages:400-416

Paul R, Lee J, Donaldson AV, et al., 2018, miR-422a suppresses SMAD4 protein expression and promotes resistance to muscle loss, Journal of Cachexia Sarcopenia and Muscle, Vol:9, ISSN:2190-6009, Pages:119-128


Alcada J, Shao DS, Griffiths MJD, et al., 2017, MECHANISMS OF REGENERATION: RETINOIC ACID ACTS VIA THE ENDOTHELIUM TO DRIVE HUMAN LUNG REPAIR, Winter Meeting of the British-Thoracic-Society, BMJ PUBLISHING GROUP, Pages:A106-A107, ISSN:0040-6376

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