Honorary Principal Research Fellow at the National Heart and Lung Institute and Consultant Physician at St Bartholomew's Hospital, London. Having qualified at London University in 1987, he was appointed as a consultant in 2001.
Clinical interests include ARDS, ICU acquired weakness, human models of ARDS and other aspects of critical illness, and extra-corporeal gas exchange techniques.
His research is focussed on cellular and molecular mechanisms of acute lung injury and repair. Current, focus of research is the effect of mechanical forces on lung injury and repair; current models include cellular stretch, in vivo murine ventilator-induced lung injury (with Prof Takata, SORA ICL), EVLP and surgical models of acute lung injury and multiple organ dysfunction. He is involved in multidisciplinary translational research which integrates basic science with clinical studies, thereby providing novel insights into critical illness.
et al., miR-422a suppresses SMAD4 protein expression and promotes resistance to muscle loss, Journal of Cachexia Sarcopenia and Muscle, ISSN:2190-5991
et al., 2017, miR-542 Promotes Mitochondrial Dysfunction and SMAD Activity and is Raised in ICU Acquired Weakness., Am J Respir Crit Care Med, ISSN:1073-449X
et al., 2017, Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema, Thorax, Vol:72, ISSN:0040-6376, Pages:510-521
et al., 2017, Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair, Disease Models & Mechanisms, Vol:10, ISSN:1754-8403, Pages:409-423
et al., Inflation pressures are associated with outcomes in ventilated patients after lung transplantation, The European Respiratory Society Annual Meeting, Pages:P259-P259, ISSN:1399-3003