Imperial College London

Dr Mark Griffiths

Faculty of MedicineNational Heart & Lung Institute

Honorary Principal Research Fellow



m.griffiths Website




363Sir Alexander Fleming BuildingSouth Kensington Campus





Honorary Principal Research Fellow at the National Heart and Lung Institute and Consultant Physician at St Bartholomew's Hospital, London. Having qualified at London University in 1987, he was appointed as a consultant in 2001.

Clinical interests include ARDS, ICU acquired weakness, human models of ARDS and other aspects of critical illness, and extra-corporeal gas exchange techniques. 

His research is focussed on cellular and molecular mechanisms of acute lung injury and repair. Current, focus of research is the effect of mechanical forces on lung injury and repair; current models include cellular stretch, in vivo murine ventilator-induced lung injury (with Prof Takata, SORA ICL), EVLP and surgical models of acute lung injury and multiple organ dysfunction. He is involved in multidisciplinary translational research which integrates basic science with clinical studies, thereby providing novel insights into critical illness.



Kemp P, Connolly, Paul R, et al., miR-424-5p reduces rRNA and protein synthesis in muscle wasting, Journal of Cachexia, Sarcopenia and Muscle, ISSN:2190-6009

Farre Garros R, Paul R, Connolly M, et al., 2017, miR-542 Promotes Mitochondrial Dysfunction and SMAD Activity and is Raised in ICU Acquired Weakness., Am J Respir Crit Care Med

Mason C, Dooley N, Griffiths M, 2017, Acute respiratory distress syndrome ., Clin Med (lond), Vol:17, Pages:439-443

McNamee JJ, Gillies MA, Barrett NA, et al., 2017, pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure., J Intensive Care Soc, Vol:18, ISSN:1751-1437, Pages:159-169


Thakuria L, Davey R, Romano R, et al., Inflation pressures are associated with outcomes in ventilated patients after lung transplantation, The European Respiratory Society Annual Meeting, Pages:P259-P259, ISSN:1399-3003

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