Summary
Professor of Critical Care Medicine at the National Heart and Lung Institute and Consultant Physician at St Bartholomew's Hospital, London. Having qualified at London University in 1987, he was appointed as a consultant in 2002.
Clinical interests include ARDS, ICU acquired weakness, human models of ARDS and other aspects of critical illness, and extra-corporeal gas exchange techniques.
His research is focussed on cellular and molecular mechanisms of acute lung injury and repair. Current, focus of research is the effect of mechanical forces on lung injury and repair; current models include cellular stretch, in vivo murine ventilator-induced lung injury (with Prof Takata, SORA ICL), EVLP and surgical models of acute lung injury and multiple organ dysfunction. He is involved in multidisciplinary translational research which integrates basic science with clinical studies, thereby providing novel insights into critical illness.
Publications
Journals
Dean C, Akram K, Yates L, et al., Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour, Nature Communications, ISSN:2041-1723
Kemp PR, Griffiths M, Polkey MI, 2018, Muscle wasting in the presence of disease, why is it so variable?, Biol Rev Camb Philos Soc
Proudfoot A, Bayliffe A, O'Kane CM, et al., 2018, Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury, Thorax, Vol:73, ISSN:0040-6376, Pages:723-730
Dunning J, Blankley S, Hoang LT, et al., 2018, Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza, Nature Immunology, Vol:19, ISSN:1529-2908, Pages:625-+
Connolly M, Paul R, Farre-Garros R, et al., 2018, miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting, Journal of Cachexia Sarcopenia and Muscle, Vol:9, ISSN:2190-6009, Pages:400-416