Imperial College London

Dr Mark Griffiths

Faculty of MedicineNational Heart & Lung Institute

Honorary Principal Research Fellow



m.griffiths Website




363Sir Alexander Fleming BuildingSouth Kensington Campus





Honorary Principal Research Fellow at the National Heart and Lung Institute and Consultant Physician at St Bartholomew's Hospital, London. Having qualified at London University in 1987, he was appointed as a consultant in 2001.

Clinical interests include ARDS, ICU acquired weakness, human models of ARDS and other aspects of critical illness, and extra-corporeal gas exchange techniques. 

His research is focussed on cellular and molecular mechanisms of acute lung injury and repair. Current, focus of research is the effect of mechanical forces on lung injury and repair; current models include cellular stretch, in vivo murine ventilator-induced lung injury (with Prof Takata, SORA ICL), EVLP and surgical models of acute lung injury and multiple organ dysfunction. He is involved in multidisciplinary translational research which integrates basic science with clinical studies, thereby providing novel insights into critical illness.



Paul R, Lee J, Donaldson AV, et al., 2018, miR-422a suppresses SMAD4 protein expression and promotes resistance to muscle loss., J Cachexia Sarcopenia Muscle, Vol:9, Pages:119-128

Proudfoot A, Bayliffe A, O'Kane CM, et al., 2018, Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury., Thorax

Ng-Blichfeldt J-P, Alcada J, Montero MA, et al., 2017, Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema, Thorax, Vol:72, ISSN:0040-6376, Pages:510-521

McNamee JJ, Gillies MA, Barrett NA, et al., 2017, pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure., J Intensive Care Soc, Vol:18, ISSN:1751-1437, Pages:159-169

Poobalasingam T, Yates LL, Walker SA, et al., 2017, Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair, Disease Models & Mechanisms, Vol:10, ISSN:1754-8403, Pages:409-423

More Publications