Summary
Professor of Critical Care Medicine at the National Heart and Lung Institute and Consultant Physician at St Bartholomew's Hospital, London. Having qualified at London University in 1987, he was appointed as a consultant in 2002.
Clinical interests include ARDS, ICU acquired weakness, human models of ARDS and other aspects of critical illness, and extra-corporeal gas exchange techniques.
His research is focussed on cellular and molecular mechanisms of acute lung injury and repair. Current, focus of research is the effect of mechanical forces on lung injury and repair; current models include cellular stretch, in vivo murine ventilator-induced lung injury (with Prof Takata, SORA ICL), EVLP and surgical models of acute lung injury and multiple organ dysfunction. He is involved in multidisciplinary translational research which integrates basic science with clinical studies, thereby providing novel insights into critical illness.
Publications
Journals
Upton PD, Park JES, De Souza PM, et al., 2020, The endothelial protective factors, BMP9 and BMP10, inhibit CCL2 release by human vascular endothelial cells, Journal of Cell Science, Vol:133, ISSN:0021-9533
Kemp P, Paul R, Neil D, et al., 2020, Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU acquired weakness, Journal of Cachexia, Sarcopenia and Muscle, ISSN:2190-6009
Powell N, 2020, Adaptation of the British Society of Gastroenterology guidelines on the management of acute severe ulcerative colitis in the context of the COVID-19 pandemic: a RAND appropriateness panel, Gut, Vol:69, ISSN:0017-5749, Pages:1769-1777
Ujma S, Carse S, Chetty A, et al., 2019, Surfactant Protein A Impairs Genital HPV16 Pseudovirus Infection by Innate Immune Cell Activation in A Murine Model, Pathogens, Vol:8
Akram K, Yates L, Mongey R, et al., 2019, Time-lapse imaging of alveologenesis in mouse precision-cut lung slices, Bio-protocol, Vol:9, ISSN:2331-8325