Dr Mark Griffiths

Faculty of Medicine, National Heart & Lung Institute

Professor of Critical Care Medicine

Contact

Location

363Sir Alexander Fleming BuildingSouth Kensington Campus

Summary

Honorary Principal Research Fellow at the National Heart and Lung Institute and Consultant Physician at St Bartholomew's Hospital, London. Having qualified at London University in 1987, he was appointed as a consultant in 2001.

Clinical interests include ARDS, ICU acquired weakness, human models of ARDS and other aspects of critical illness, and extra-corporeal gas exchange techniques.

His research is focussed on cellular and molecular mechanisms of acute lung injury and repair. Current, focus of research is the effect of mechanical forces on lung injury and repair; current models include cellular stretch, in vivo murine ventilator-induced lung injury (with Prof Takata, SORA ICL), EVLP and surgical models of acute lung injury and multiple organ dysfunction. He is involved in multidisciplinary translational research which integrates basic science with clinical studies, thereby providing novel insights into critical illness.

Publications

Journals

Proudfoot A, Bayliffe A, O'Kane CM, et al.Proudfoot A, Bayliffe A, O'Kane CM, Wright T, Serone A, Bareille PJ, Brown V, Hamid UI, Chen Y, Wilson R, Cordy J, Morley P, de Wildt R, Elborn S, Hind M, Chilvers ER, Griffiths M, Summers C, McAuley DF close, 2018, Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury, Thorax, Vol:73, ISSN:0040-6376, Pages:723-730

Dunning J, Blankley S, Hoang LT, et al.Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJM close, 2018, Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza, Nature Immunology, Vol:19, ISSN:1529-2908, Pages:625-+

Connolly M, Paul R, Farre-Garros R, et al.Connolly M, Paul R, Farre-Garros R, Natanek SA, Bloch S, Lee J, Lorenzo JP, Patel H, Cooper C, Sayer AA, Wort SJ, Griffiths M, Polkey MI, Kemp PR close, 2018, miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting, Journal of Cachexia Sarcopenia and Muscle, Vol:9, ISSN:2190-6009, Pages:400-416

Paul R, Lee J, Donaldson AV, et al.Paul R, Lee J, Donaldson AV, Connolly M, Sharif M, Natanek SA, Rosendahl U, Polkey MI, Griffiths M, Kemp PR close, 2018, miR-422a suppresses SMAD4 protein expression and promotes resistance to muscle loss, Journal of Cachexia Sarcopenia and Muscle, Vol:9, ISSN:2190-6009, Pages:119-128

Ng-Blichfeldt J-P, Alcada J, Montero MA, et al.Ng-Blichfeldt J-P, Alcada J, Montero MA, Dean CH, Griesenbach U, Griffiths MJ, Hind M close, 2017, Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema, Thorax, Vol:72, ISSN:0040-6376, Pages:510-521

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