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@article{Merritt:2015:10.1186/s12916-015-0484-3,
author = {Merritt, MA and Riboli, E and Murphy, N and Kadi, M and Tjønneland, A and Olsen, A and Overvad, K and Dossus, L and Dartois, L and Clavel-Chapelon, F and Fortner, RT and Katzke, VA and Boeing, H and Trichopoulou, A and Lagiou, P and Trichopoulos, D and Palli, D and Sieri, S and Tumino, R and Sacerdote, C and Panico, S and Bueno-de-Mesquita, HB and Peeters, PH and Lund, E and Nakamura, A and Weiderpass, E and Quirós, JR and Agudo, A and Molina-Montes, E and Larrañaga, N and Dorronsoro, M and Cirera, L and Barricarte, A and Olsson, A and Butt, S and Idahl, A and Lundin, E and Wareham, N and Key, TJ and Brennan, P and Ferrari, P and Wark, PA and Norat, T and Cross, AJ and Gunter, MJ},
doi = {10.1186/s12916-015-0484-3},
journal = {BMC Medicine},
title = {Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study},
url = {http://dx.doi.org/10.1186/s12916-015-0484-3},
volume = {13},
year = {2015}
}

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TY  - JOUR
AB  - Background: Reproductive events are associated with important physiologic changes yet little is known abouthow reproductive factors influence long term health in women. Our objective was to assess the relation ofreproductive characteristics with all-cause and cause-specific mortality risk.Methods: The analysis was performed in the European Investigation into Cancer and Nutrition prospectivecohort study that enrolled >500,000 women and men (1992-2000) who were residing in a giventown/geographic area in 10 European countries. The current analysis included 322,972 eligible women aged 25-70 years with 99% complete follow-up for vital status. We assessed reproductive characteristics reported at thestudy baseline including parity, age at the first birth, breastfeeding, infertility, oral contraceptive use, age atmenarche and menopause, total ovulatory years and history of oophorectomy/hysterectomy. Hazard ratios(HRs) and 95% confidence intervals (CIs) for mortality were determined using Cox proportional hazardsregression models adjusted for menopausal status, body mass index, physical activity, education level andsmoking status/intensity and duration.Results: During a mean follow-up of 12.9 years, 14,383 deaths occurred. The HR (95% CI) for risk of all-causemortality was lower in parous versus nulliparous women, 0.80 (0.76-0.84), in women who had ever versusnever breastfed, 0.92 (0.87-0.97), in ever versus never users of oral contraceptives (among non-smokers), 0.90(0.86-0.95), and in women reporting a later age at menarche (≥15 years versus <12), 0.90 (0.85-0.96), P fortrend=0.038.Conclusions: Childbirth, breastfeeding, oral contraceptive use, and a later age at menarche were associated withbetter health outcomes. These findings may contribute to the development of improved strategies to promotebetter long term health in women.
AU  - Merritt,MA
AU  - Riboli,E
AU  - Murphy,N
AU  - Kadi,M
AU  - Tjønneland,A
AU  - Olsen,A
AU  - Overvad,K
AU  - Dossus,L
AU  - Dartois,L
AU  - Clavel-Chapelon,F
AU  - Fortner,RT
AU  - Katzke,VA
AU  - Boeing,H
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Trichopoulos,D
AU  - Palli,D
AU  - Sieri,S
AU  - Tumino,R
AU  - Sacerdote,C
AU  - Panico,S
AU  - Bueno-de-Mesquita,HB
AU  - Peeters,PH
AU  - Lund,E
AU  - Nakamura,A
AU  - Weiderpass,E
AU  - Quirós,JR
AU  - Agudo,A
AU  - Molina-Montes,E
AU  - Larrañaga,N
AU  - Dorronsoro,M
AU  - Cirera,L
AU  - Barricarte,A
AU  - Olsson,A
AU  - Butt,S
AU  - Idahl,A
AU  - Lundin,E
AU  - Wareham,N
AU  - Key,TJ
AU  - Brennan,P
AU  - Ferrari,P
AU  - Wark,PA
AU  - Norat,T
AU  - Cross,AJ
AU  - Gunter,MJ
DO  - 10.1186/s12916-015-0484-3
PY  - 2015///
SN  - 1741-7015
TI  - Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-015-0484-3
UR  - http://hdl.handle.net/10044/1/26680
VL  - 13
ER  -

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