Publications

BibTex format

@article{Kong:2015:10.1158/1055-9965.EPI-15-0422,
author = {Kong, SY and Takeuchi, M and Hyogo, H and McKeown-Eyssen, G and Yamagishi, S-I and Chayama, K and O'Brien, PJ and Ferrari, P and Overvad, K and Olsen, A and Tjonneland, A and Boutron-Ruault, M-C and Bastide, N and Carbonnel, F and Kuehn, T and Kaaks, R and Boeing, H and Aleksandrova, K and Trichopoulou, A and Lagiou, P and Vasilopoulou, E and Masala, G and Pala, V and De, Magistris MS and Tumino, R and Naccarati, A and Bueno-De-Mesquita, HB and Peeters, PH and Weiderpass, E and Quiros, JR and Jakszyn, P and Sanchez, M-J and Dorronsoro, M and Gavrila, D and Ardanaz, E and Rutegard, M and Nystroem, H and Wareham, NJ and Khaw, K-T and Bradbury, KE and Romieu, I and Freisling, H and Stavropoulou, F and Gunter, MJ and Cross, AJ and Riboli, E and Jenab, M and Bruce, WR},
doi = {10.1158/1055-9965.EPI-15-0422},
journal = {Cancer Epidemiology Biomarkers & Prevention},
pages = {1855--1863},
title = {The association between glyceraldehyde-derived advanced glycation end-products and colorectal cancer risk},
url = {http://dx.doi.org/10.1158/1055-9965.EPI-15-0422},
volume = {24},
year = {2015}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehyde-derived advanced glycation end-products (glycer-AGEs), which may promote colorectal cancer through their proinflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of colorectal cancer.Methods: A total of 1,055 colorectal cancer cases (colon n = 659; rectal n = 396) were matchced (1:1) to control subjects. Circulating glycer-AGEs were measured by a competitive ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (95% CI), adjusting for potential confounding factors, including smoking, alcohol, physical activity, body mass index, and diabetes status.Results: Elevated glycer-AGEs levels were not associated with colorectal cancer risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82–1.49). Subgroup analyses showed possible divergence by anatomical subsites (OR for colon cancer, 0.83; 95% CI, 0.57–1.22; OR for rectal cancer, 1.90; 95% CI, 1.14–3.19; Pheterogeneity = 0.14).Conclusions: In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer.Impact: Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in colorectal cancer development.
AU  - Kong,SY
AU  - Takeuchi,M
AU  - Hyogo,H
AU  - McKeown-Eyssen,G
AU  - Yamagishi,S-I
AU  - Chayama,K
AU  - O'Brien,PJ
AU  - Ferrari,P
AU  - Overvad,K
AU  - Olsen,A
AU  - Tjonneland,A
AU  - Boutron-Ruault,M-C
AU  - Bastide,N
AU  - Carbonnel,F
AU  - Kuehn,T
AU  - Kaaks,R
AU  - Boeing,H
AU  - Aleksandrova,K
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Vasilopoulou,E
AU  - Masala,G
AU  - Pala,V
AU  - De,Magistris MS
AU  - Tumino,R
AU  - Naccarati,A
AU  - Bueno-De-Mesquita,HB
AU  - Peeters,PH
AU  - Weiderpass,E
AU  - Quiros,JR
AU  - Jakszyn,P
AU  - Sanchez,M-J
AU  - Dorronsoro,M
AU  - Gavrila,D
AU  - Ardanaz,E
AU  - Rutegard,M
AU  - Nystroem,H
AU  - Wareham,NJ
AU  - Khaw,K-T
AU  - Bradbury,KE
AU  - Romieu,I
AU  - Freisling,H
AU  - Stavropoulou,F
AU  - Gunter,MJ
AU  - Cross,AJ
AU  - Riboli,E
AU  - Jenab,M
AU  - Bruce,WR
DO  - 10.1158/1055-9965.EPI-15-0422
EP  - 1863
PY  - 2015///
SN  - 1538-7755
SP  - 1855
TI  - The association between glyceraldehyde-derived advanced glycation end-products and colorectal cancer risk
T2  - Cancer Epidemiology Biomarkers & Prevention
UR  - http://dx.doi.org/10.1158/1055-9965.EPI-15-0422
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000366129100007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/42694
VL  - 24
ER  -

Download

ProfessorMarcGunter

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)