Imperial College London
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ProfessorMarcGunter

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 2623m.gunter

 
 
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Location

 

VC2Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schmidt:2015:10.1038/ejcn.2015.144,
author = {Schmidt, JA and Rinaldi, S and Scalbert, A and Ferrari, P and Achaintre, D and Gunter, MJ and Appleby, PN and Key, TJ and Travis, RC},
doi = {10.1038/ejcn.2015.144},
journal = {European Journal of Clinical Nutrition},
pages = {306--312},
title = {Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort},
url = {http://dx.doi.org/10.1038/ejcn.2015.144},
volume = {70},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background/Objectives: We aimed to investigate the differences in plasma concentrations and in intakes of amino acids between male meat-eaters, fish-eaters, vegetarians and vegans in the Oxford arm of the European Prospective Investigation into Cancer and Nutrition.Subjects/Methods: This cross-sectional analysis included 392 men, aged 30–49 years. Plasma amino acid concentrations were measured with a targeted metabolomic approach using mass spectrometry, and dietary intake was assessed using a food frequency questionnaire. Differences between diet groups in mean plasma concentrations and intakes of amino acids were examined using analysis of variance, controlling for potential confounding factors and multiple testing.Results: In plasma, concentrations of 6 out of 21 amino acids varied significantly by diet group, with differences of −13% to +16% between meat-eaters and vegans. Concentrations of methionine, tryptophan and tyrosine were highest in fish-eaters and vegetarians, followed by meat-eaters, and lowest in vegans. A broadly similar pattern was seen for lysine, whereas alanine concentration was highest in fish-eaters and lowest in meat-eaters. For glycine, vegans had the highest concentration and meat-eaters the lowest. Intakes of all 18 dietary amino acids differed by diet group; for the majority of these, intake was highest in meat-eaters followed by fish-eaters, then vegetarians and lowest in vegans (up to 47% lower than in meat-eaters).Conclusions: Men belonging to different habitual diet groups have significantly different plasma concentrations of lysine, methionine, tryptophan, alanine, glycine and tyrosine. However, the differences in plasma concentrations were less marked than and did not necessarily mirror those seen for amino acid intakes.
AU  - Schmidt,JA
AU  - Rinaldi,S
AU  - Scalbert,A
AU  - Ferrari,P
AU  - Achaintre,D
AU  - Gunter,MJ
AU  - Appleby,PN
AU  - Key,TJ
AU  - Travis,RC
DO  - 10.1038/ejcn.2015.144
EP  - 312
PY  - 2015///
SN  - 1476-5640
SP  - 306
TI  - Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort
T2  - European Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.1038/ejcn.2015.144
UR  - http://hdl.handle.net/10044/1/41272
VL  - 70
ER  -
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