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@article{Merritt:2016:10.3945/ajcn.115.118588,
author = {Merritt, MA and Tzoulaki, J and van, den Brandt PA and Schouten, LJ and Tsilidis, KK and Weiderpass, E and Patel, CJ and Tjonneland, A and Hansen, L and Overvad, K and His, M and Dartois, L and Boutron-Ruault, M-C and Fortner, RT and Kaaks, R and Aleksandrova, K and Boeing, H and Trichopoulou, A and Lagiou, P and Bamia, C and Palli, D and Krogh, V and Tumino, R and Ricceri, F and Mattiello, A and Bueno-de-Mesquita, HB and Onland-Moret, NC and Peeters, PH and Skeie, G and Jareid, M and Quiros, JR and Obon-Santacana, M and Sanchez, M-J and Chamosa, S and Huerta, JM and Barricarte, A and Dias, JA and Sonestedt, E and Idahl, A and Lundin, E and Wareham, NJ and Khaw, K-T and Travis, RC and Ferrari, P and Riboli, E and Gunter, MJ},
doi = {10.3945/ajcn.115.118588},
journal = {American Journal of Clinical Nutrition},
pages = {161--167},
title = {Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study},
url = {http://dx.doi.org/10.3945/ajcn.115.118588},
volume = {103},
year = {2016}
}

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TY  - JOUR
AB  - Background: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.Objective: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.Design: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.Results: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).Conclusion: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.
AU  - Merritt,MA
AU  - Tzoulaki,J
AU  - van,den Brandt PA
AU  - Schouten,LJ
AU  - Tsilidis,KK
AU  - Weiderpass,E
AU  - Patel,CJ
AU  - Tjonneland,A
AU  - Hansen,L
AU  - Overvad,K
AU  - His,M
AU  - Dartois,L
AU  - Boutron-Ruault,M-C
AU  - Fortner,RT
AU  - Kaaks,R
AU  - Aleksandrova,K
AU  - Boeing,H
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Bamia,C
AU  - Palli,D
AU  - Krogh,V
AU  - Tumino,R
AU  - Ricceri,F
AU  - Mattiello,A
AU  - Bueno-de-Mesquita,HB
AU  - Onland-Moret,NC
AU  - Peeters,PH
AU  - Skeie,G
AU  - Jareid,M
AU  - Quiros,JR
AU  - Obon-Santacana,M
AU  - Sanchez,M-J
AU  - Chamosa,S
AU  - Huerta,JM
AU  - Barricarte,A
AU  - Dias,JA
AU  - Sonestedt,E
AU  - Idahl,A
AU  - Lundin,E
AU  - Wareham,NJ
AU  - Khaw,K-T
AU  - Travis,RC
AU  - Ferrari,P
AU  - Riboli,E
AU  - Gunter,MJ
DO  - 10.3945/ajcn.115.118588
EP  - 167
PY  - 2016///
SN  - 1938-3207
SP  - 161
TI  - Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study
T2  - American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.3945/ajcn.115.118588
UR  - http://hdl.handle.net/10044/1/60115
VL  - 103
ER  -

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