Publications

BibTex format

@article{Gunter:2017:10.7326/M16-2945,
author = {Gunter, MJ and Murphy, N and Cross, A and Dossus, L and Dartois, L and Fagherazzzi, G and Kaaks, R and Kuhn, T and Boeing, H and Aleksandrova, K and Tjonneland, A and Olsen, A and Overvad, K and Larsen, SC and Redondo, Cornejo ML and Agudo, A and Sanchez, Perez MJ and Altzibar, JM and Navarro, C and Ardanaz, E and Khaw, KT and Butterworth, A and Bradbury, KE and Trichopoulou, A and Lagiou, P and Trichopoulos, D and Palli, D and Grioni, S and Vineis, P and Panico, S and Tumino, R and Bueno-de-Mesquita, B and Siersema, P and Landberg, R and Weiderpass, E and Skeie, G and Braaten, T and Brennan, P and Licaj, I and Muller, DC and Sinha, R and Wareham, N and Riboli, E},
doi = {10.7326/M16-2945},
journal = {Annals of Internal Medicine},
pages = {236--247},
title = {Coffee drinking and mortality in 10 European countries:  a multinational cohort Study},
url = {http://dx.doi.org/10.7326/M16-2945},
volume = {167},
year = {2017}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear.Objective:To examine whether coffee consumption is associated with all-cause and cause-specific mortality.Design:Prospective cohort study.Setting:10 European countries.Participants:521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition).Measurements:Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800).Results:During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; γ-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels.Limitations:Reverse causality may have biased the findings; however, results did not differ afte
AU  - Gunter,MJ
AU  - Murphy,N
AU  - Cross,A
AU  - Dossus,L
AU  - Dartois,L
AU  - Fagherazzzi,G
AU  - Kaaks,R
AU  - Kuhn,T
AU  - Boeing,H
AU  - Aleksandrova,K
AU  - Tjonneland,A
AU  - Olsen,A
AU  - Overvad,K
AU  - Larsen,SC
AU  - Redondo,Cornejo ML
AU  - Agudo,A
AU  - Sanchez,Perez MJ
AU  - Altzibar,JM
AU  - Navarro,C
AU  - Ardanaz,E
AU  - Khaw,KT
AU  - Butterworth,A
AU  - Bradbury,KE
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Trichopoulos,D
AU  - Palli,D
AU  - Grioni,S
AU  - Vineis,P
AU  - Panico,S
AU  - Tumino,R
AU  - Bueno-de-Mesquita,B
AU  - Siersema,P
AU  - Landberg,R
AU  - Weiderpass,E
AU  - Skeie,G
AU  - Braaten,T
AU  - Brennan,P
AU  - Licaj,I
AU  - Muller,DC
AU  - Sinha,R
AU  - Wareham,N
AU  - Riboli,E
DO  - 10.7326/M16-2945
EP  - 247
PY  - 2017///
SN  - 1539-3704
SP  - 236
TI  - Coffee drinking and mortality in 10 European countries:  a multinational cohort Study
T2  - Annals of Internal Medicine
UR  - http://dx.doi.org/10.7326/M16-2945
UR  - http://hdl.handle.net/10044/1/48614
VL  - 167
ER  -

Download

ProfessorMarcGunter

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)