Imperial College London

ProfessorMarjo-RiittaJarvelin

Faculty of MedicineSchool of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3345m.jarvelin

 
 
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Location

 

156Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
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1367 results found

Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, Bradfield JP, Kreiner-Moller E, Huikari V, Metrustry S, Lunetta KL, Painter JN, Hottenga J-J, Allard C, Barton SJ, Espinosa A, Marsh JA, Potter C, Zhang G, Ang W, Berry DJ, Bouchard L, Das S, Hakonarson H, Heikkinen J, Helgeland O, Hocher B, Hofman A, Inskip HM, Jones SE, Kogevinas M, Lind PA, Marullo L, Medland SE, Murray A, Murray JC, Njolstad PR, Nohr EA, Reichetzeder C, Ring SM, Ruth KS, Santa-Marina L, Scholtens DM, Sebert S, Sengpiel V, Tuke MA, Vaudel M, Weedon MN, Willemsen G, Wood AR, Yaghootkar H, Muglia LJ, Bartels M, Relton CL, Pennell CE, Chatzi L, Estivill X, Holloway JW, Boomsma DI, Montgomery GW, Murabito JM, Spector TD, Power C, Jarvelin M-R, Bisgaard H, Grant SFA, Sorensen TIA, Jaddoe VW, Jacobsson B, Melbye M, McCarthy MI, Hattersley AT, Hayes MG, Frayling TM, Hivert M-F, Felix JF, Hypponen E, Lowe WL, Evans DM, Lawlor DA, Feenstra B, Freathy RMet al., 2018, Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics, HUMAN MOLECULAR GENETICS, Vol: 27, Pages: 742-756, ISSN: 0964-6906

JOURNAL ARTICLE

Björkqvist J, Pesonen A-K, Kuula L, Matinolli H-M, Lano A, Sipola-Leppänen M, Tikanmäki M, Wolke D, Järvelin M-R, Eriksson JG, Andersson S, Vääräsmäki M, Heinonen K, Räikkönen K, Hovi P, Kajantie Eet al., 2018, Premature birth and circadian preference in young adulthood: evidence from two birth cohorts., Chronobiol Int, Pages: 1-10

A preference for eveningness (being a "night owl") and preterm birth (<37 weeks of gestation) are associated with similar adversities, such as elevated blood pressure, impaired glucose regulation, poorer physical fitness, and lower mood. Yet, it remains unclear if and how preterm birth is associated with circadian preference. The aim of this study was to assess this association across the whole gestation range, using both objective and subjective measurements of circadian preference. Circadian preference was measured among 594 young adults (mean age 24.3 years, SD 1.3) from two cohorts: the ESTER study and the Arvo Ylppö Longitudinal Study. We compared 83 participants born early preterm (<34 weeks) and 165 late preterm (34 to <37 weeks) with those born at term (≥37 weeks, n = 346). We also compared very low birth weight (VLBW, <1500 g) participants with term-born controls. We obtained objective sleep data with actigraphs that were worn for a mean period of 6.8 (SD 1.4) nights. Our primary outcome was sleep midpoint during weekdays and weekend. The sleep midpoint is the half-way time between falling asleep and waking up, and it represents sleep timing. We also investigated subjective chronotype with the Morningness-Eveningness Questionnaire (MEQ) in 688 (n = 138/221/329) ESTER participants. The MEQ consists of 19 questions, which estimates the respondent to be of a "morning", "evening," or "intermediate" chronotype, based on the Morningness-Eveningness Score (MES). We analyzed the data from the actigraphs and the MES with three linear regression models, and analyzed distribution of the chronotype class with Pearson χ2. There were no consistent differences across the study groups in sleep midpoint. As compared with those born at term, the mean differences in minutes:seconds and 95% confidence intervals for the sleep midpoint were: early preterm weekdays 11

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Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmueller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bonnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Alves AC, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliovaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin M-R, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kahonen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee Y-A, Lehtimaki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Marenholz I, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Melen E, Meyers D, Michel S, Mohamdi H, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Pershagen G, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Schlunssen V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Siroux V, Smith LJ, Solodilova M, Standl M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Tiesler CMT, Torgerson DG, Tsunoda T, Uitterlinden AG, van der Valk RJP, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Widen E, Willemsen G, Williams LK, Wouterset al., 2018, Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks, NATURE GENETICS, Vol: 50, Pages: 42-+, ISSN: 1061-4036

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Dijk FN, Xu C, Melén E, Carsin A-E, Kumar A, Nolte IM, Gruzieva O, Pershagen G, Grotenboer NS, Savenije OEM, Antó JM, Lavi I, Dobaño C, Bousquet J, van der Vlies P, van der Valk RJP, de Jongste JC, Nawijn MC, Guerra S, Postma DS, Koppelman GHet al., 2018, Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma., Eur Respir J, Vol: 51

Interleukin-1 receptor-like 1 (IL1RL1) is an important asthma gene. (Epi)genetic regulation of IL1RL1 protein expression has not been established. We assessed the association between IL1RL1 single nucleotide polymorphisms (SNPs), IL1RL1 methylation and serum IL1RL1-a protein levels, and aimed to identify causal pathways in asthma.Associations of IL1RL1 SNPs with asthma were determined in the Dutch Asthma Genome-wide Association Study cohort and three European birth cohorts, BAMSE (Children/Barn, Allergy, Milieu, Stockholm, an Epidemiological survey), INMA (Infancia y Medio Ambiente) and PIAMA (Prevention and Incidence of Asthma and Mite Allergy), participating in the Mechanisms of the Development of Allergy study. We performed blood DNA IL1RL1 methylation quantitative trait locus (QTL) analysis (n=496) and (epi)genome-wide protein QTL analysis on serum IL1RL1-a levels (n=1462). We investigated the association of IL1RL1 CpG methylation with asthma (n=632) and IL1RL1-a levels (n=548), with subsequent causal inference testing. Finally, we determined the association of IL1RL1-a levels with asthma and its clinical characteristics (n=1101).IL1RL1 asthma-risk SNPs strongly associated with IL1RL1 methylation (rs1420101; p=3.7×10-16) and serum IL1RL1-a levels (p=2.8×10-56). IL1RL1 methylation was not associated with asthma or IL1RL1-a levels. IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associated IL1RL1 SNPs strongly regulate IL1RL1 methylation and serum IL1RL1-a levels, yet neither these IL1RL1-methylation CpG sites nor IL1RL1-a levels are associated with asthma.

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Felix JF, Joubert BR, Baccarelli AA, Sharp GC, Almqvist C, Annesi-Maesano I, Arshad H, Baiz N, Bakermans-Kranenburg MJ, Bakulski KM, Binder EB, Bouchard L, Breton CV, Brunekreef B, Brunst KJ, Burchard EG, Bustamante M, Chatzi L, Munthe-Kaas MC, Corpeleijn E, Czamara D, Dabelea D, Smith GD, De Boever P, Duijts L, Dwyer T, Eng C, Eskenazi B, Everson TM, Falahi F, Fallin MD, Farchi S, Fernandez MF, Gao L, Gaunt TR, Ghantous A, Gillman MW, Gonseth S, Grote V, Gruzieva O, Haberg SE, Herceg Z, Hivert M-F, Holland N, Holloway JW, Hoyo C, Hu D, Huang R-C, Huen K, Jarvelin M-R, Jima DD, Just AC, Karagas MR, Karlsson R, Karmaus W, Kechris KJ, Kere J, Kogevinas M, Koletzko B, Koppelman GH, Kupers LK, Ladd-Acosta C, Lahti J, Lambrechts N, Langie SAS, Lie RT, Liu AH, Magnus MC, Magnus P, Maguire RL, Marsit CJ, McArdle W, Melen E, Melton P, Murphy SK, Nawrot TS, Nistico L, Nohr EA, Nordlund B, Nystad W, Oh SS, Oken E, Page CM, Perron P, Pershagen G, Pizzi C, Plusquin M, Raikkonen K, Reese SE, Reischl E, Richiardi L, Ring S, Roy RP, Rzehak P, Schoeters G, Schwartz DA, Sebert S, Snieder H, Sorensen TIA, Starling AP, Sunyer J, ATaylor J, Tiemeier H, Ullemar V, Vafeiadi M, Van Ijzendoorn MH, Vonk JM, Vriens A, Vrijheid M, Wang P, Wiemels JL, Wilcox AJ, Wright RJ, Xu C-J, Xu Z, Yang IV, Yousefi P, Zhang H, Zhang W, Zhao S, Agha G, Relton CL, Jaddoe VWV, London SJet al., 2018, Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 47, Pages: 22-+, ISSN: 0300-5771

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Jiang X, O'Reilly PF, Aschard H, Hsu Y-H, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Voelzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang W-Y, Van Schoor NM, van der Velde N, de Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu C-T, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, van Heemst D, Kleber ME, Maerz W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin M-R, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaelsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimaki T, Lyytikainen L-P, Kahonen M, Raitakari OT, Mikkila V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw K-T, Butterworth AS, Danesh J, Spector T, Wang TJ, Hypponen E, Kraft P, Kiel DPet al., 2018, Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723

JOURNAL ARTICLE

Liuhanen J, Suvisaari J, Kajantie E, Miettunen J, Sarin A-P, Jarvelin M-R, Lonnqvist J, Veijola J, Paunio Tet al., 2018, Interaction between compound genetic risk for schizophrenia and high birth weight contributes to social anhedonia and schizophrenia in women, PSYCHIATRY RESEARCH, Vol: 259, Pages: 148-153, ISSN: 0165-1781

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Matinolli H-M, Männistö S, Sipola-Leppänen M, Tikanmäki M, Heinonen K, Eriksson JG, Wolke D, Lano A, Järvelin M-R, Vääräsmäki M, Räikkönen K, Kajantie Eet al., 2018, Food and nutrient intakes in young adults born preterm., Pediatr Res, Vol: 83, Pages: 589-596

BackgroundAdults born preterm have higher levels of cardiometabolic risk factors than their term-born peers. Studies have suggested that at least those born smallest eat less healthily. We examined the association between early (<34 weeks) and late (34-36 weeks) preterm birth and diet and food preferences in adult age.MethodsParticipants of two cohort studies located in Finland completed a validated food frequency questionnaire (FFQ) at the age of 24 years to assess their usual diet and the adherence to healthy eating guidelines by using a recommended diet index (RDI). Overall, 182 were born early preterm, 352 late preterm, and 631 were term-born controls.ResultsYoung women born early preterm scored 0.77 points (95% confidence interval (CI) 0.03, 1.51) lower in RDI when adjusted for sex, age, parental education, and early-life confounders, indicating a lower quality of diet. There were no differences between young women born late preterm and controls or among men. When food groups were assessed separately, men born early preterm had lower consumption of fruits and berries than controls.ConclusionsYoung women born early preterm have poorer adherence to the healthy eating guidelines than their peers born at term. Differences in diet may contribute to an increased cardiometabolic risk among adults born early preterm.

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Melén E, Barouki R, Barry M, Boezen HM, Hoffmann B, Krauss-Etschmann S, Koppelman GH, Forsberg Bet al., 2018, Promoting respiratory public health through epigenetics research: an ERS Environment Health Committee workshop report., Eur Respir J, Vol: 51

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Schierding W, Antony J, Karhunen V, Vaarasmaki M, Franks S, Elliott P, Kajantie E, Sebert S, Blakemore A, Horsfield JA, Jarvelin M-R, O'Sullivan JM, Cutfield WSet al., 2018, GWAS on prolonged gestation (post-term birth): analysis of successive Finnish birth cohorts, JOURNAL OF MEDICAL GENETICS, Vol: 55, Pages: 55-63, ISSN: 0022-2593

JOURNAL ARTICLE

Abass K, Koiranen M, Mazej D, Tratnik JS, Horvat M, Hakkola J, Jarvelin M-R, Rautio Aet al., 2017, Arsenic, cadmium, lead and mercury levels in blood of Finnish adults and their relation to diet, lifestyle habits and sociodemographic variables, ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, Vol: 24, Pages: 1347-1362, ISSN: 0944-1344

JOURNAL ARTICLE

Alves AC, Valcarcel B, Maekinen V-P, Morin-Papunen L, Sebert S, Kangas AJ, Soininen P, Das S, De Iorio M, Coin L, Ala-Korpela M, Jaervelin M-R, Franks Set al., 2017, Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity, INTERNATIONAL JOURNAL OF OBESITY, Vol: 41, Pages: 1331-1340, ISSN: 0307-0565

JOURNAL ARTICLE

Aschard H, Tobin MD, Hancock DB, Skurnik D, Sood A, James A, Smith AV, Manichaikul A, Campbell A, Prins BP, Hayward C, Loth D, Porteous DJ, Strachan DP, Zeggini E, O'Connor GT, Brusselle GG, Boezen HM, Schulz H, Deary IJ, Hall IP, Rudan I, Kaprio J, Wilson JF, Wilk JB, Huffman JE, Zhao JH, de Jong K, Lyytikainen L-P, Wain LV, Jarvelin M-R, Kahonen M, Fornage M, Polasek O, Cassano PA, Barr RG, Rawal R, Harris SE, Gharib SA, Enroth S, Heckbert SR, Lehtimaki T, Gyllensten U, Jackson VE, Gudnason V, Tang W, Dupuis J, Artigas MS, Joshi AD, London SJ, Kraft Pet al., 2017, Evidence for large-scale gene-by-smoking interaction effects on pulmonary function, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 46, Pages: 894-904, ISSN: 0300-5771

JOURNAL ARTICLE

Benner C, Havulinna AS, Jarvelin M-R, Salomaa V, Ripatti S, Pirinen Met al., 2017, Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 101, Pages: 539-551, ISSN: 0002-9297

JOURNAL ARTICLE

Berry DJ, Dutton J, Fraser WD, Jarvelin M-R, Hypponen Eet al., 2017, Harmonization Study Between LC-MS/MS and Diasorin RIA for Measurement of 25-Hydroxyvitamin D Concentrations in a Large Population Survey, JOURNAL OF CLINICAL LABORATORY ANALYSIS, Vol: 31, ISSN: 0887-8013

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Carpaij OA, Nieuwenhuis MAE, Koppelman GH, van den Berge M, Postma DS, Vonk JMet al., 2017, Childhood factors associated with complete and clinical asthma remission at 25 and 49 years., Eur Respir J, Vol: 49

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Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, Altmaier E, Amini M, Barbieri CM, Boutin T, Campbell A, Demerath E, Giri A, He C, Hottenga JJ, Karlsson R, Kolcic I, Loh P-R, Lunetta KL, Mangino M, Marco B, McMahon G, Medland SE, Nolte IM, Noordam R, Nutile T, Paternoster L, Perjakova N, Porcu E, Rose LM, Schraut KE, Segre AV, Smith AV, Stolk L, Teumer A, Andrulis IL, Bandinelli S, Beckmann MW, Benitez J, Bergmann S, Bochud M, Boerwinkle E, Bojesen SE, Bolla MK, Brand JS, Brauch H, Brenner H, Broer L, Bruning T, Buring JE, Campbell H, Catamo E, Chanock S, Chenevix-Trench G, Corre T, Couch FJ, Cousminer DL, Cox A, Crisponi L, Czene K, Smith GD, de Geus EJCN, de Mutsert R, De Vivo I, Dennis J, Devilee P, dos-Santos-Silva I, Dunning AM, Eriksson JG, Fasching PA, Fernandez-Rhodes L, Ferrucci L, Flesch-Janys D, Franke L, Gabrielson M, Gandin I, Giles GG, Grallert H, Gudbjartsson DF, Guenel P, Hall P, Hallberg E, Hamann U, Harris TB, Hartman CA, Heiss G, Hooning MJ, Hopper JL, Hu F, Hunter DJ, Ikram MA, Im HK, Jarvelin M-R, Joshi PK, Karasik D, Kellis M, Kutalik Z, LaChance G, Lambrechts D, Langenberg C, Launer LJ, Laven JSE, Lenarduzzi S, Li J, Lind PA, Lindstrom S, Liu Y, Luan J, Magi R, Mannermaa A, Mbarek H, McCarthy MI, Meisinger C, Meitinger T, Menni C, Metspalu A, Michailidou K, Milani L, Milne RL, Montgomery GW, Mulligan AM, Nalls MA, Navarro P, Nevanlinna H, Nyholt DR, Oldehinkel AJ, O'Mara TA, Padmanabhan S, Palotie A, Pedersen N, Peters A, Peto J, Pharoah PDP, Pouta A, Radice P, Rahman I, Ring SM, Robino A, Rosendaal FR, Rudan I, Rueedi R, Ruggiero D, Sala CF, Schmidt MK, Scott RA, Shah M, Sorice R, Southey MC, Sovio U, Stampfer M, Steri M, Strauch K, Tanaka T, Tikkanen E, Timpson NJ, Traglia M, Truong T, Tyrer JP, Uitterlinden AG, Edwards DRV, Vitart V, Voelker U, Vollenweider P, Wang Q, Widen E, van Dijk KW, Willemsen G, Winqvist R, Wolffenbuttel BHR, Zhao JH, Zoledziewska M, Zygmunt M, Alizadeh BZ Bet al., 2017, Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk, NATURE GENETICS, Vol: 49, Pages: 834-+, ISSN: 1061-4036

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Ferreira DLS, Williams DM, Kangas AJ, Soininen P, Ala-Korpela M, Smith GD, Jarvelin M-R, Lawlor DAet al., 2017, Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts, PLOS MEDICINE, Vol: 14, ISSN: 1549-1676

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Gill D, Sheehan NA, Wielscher M, Shrine N, Amaral AFS, Thompson JR, Granell R, Leynaert B, Real FG, Hall IP, Tobin MD, Auvinen J, Ring SM, Jarvelin M-R, Wain LV, Henderson J, Jarvis D, Minelli Cet al., 2017, Age at menarche and lung function: a Mendelian randomization study, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 32, Pages: 701-710, ISSN: 0393-2990

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Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renstrom F, Quaye L, Eicher JD, Hayes JE, Cornelis M, Kutalik Z, Lim E, Luan J, Huffman JE, Zhang W, Zhao W, Griffin PJ, Haller T, Ahmad S, Marques-Vidal PM, Bien S, Yengo L, Teumer A, Smith AV, Kumari M, Harder MN, Justesen JM, Kleber ME, Hollensted M, Lohman K, Rivera NV, Whitfield JB, Zhao JH, Stringham HM, Lyytikainen L-P, Huppertz C, Willemsen G, Peyrot WJ, Wu Y, Kristiansson K, Demirkan A, Fornage M, Hassinen M, Bielak LF, Cadby G, Tanaka T, Magl R, Van der Most PJ, Jackson AU, Bragg-Gresham JL, Vitart V, Marten J, Navarro P, Bellis C, Pasko D, Johansson A, Snitker S, Cheng Y-C, Eriksson J, Lim U, Aadahl M, Adair LS, Amin N, Balkau B, Auvinen J, Beilby J, Bergman RN, Bergmann S, Bertoni AG, Blangero J, Bonnefond A, Bonnycastle LL, Borja JB, Brage S, Busonero F, Buyske S, Campbell H, Chines PS, Collins FS, Corre T, Smith GD, Delgado GE, Dueker N, Doerr M, Ebeling T, Eiriksdottir G, Esko T, Faul JD, Fu M, Faerch K, Gieger C, Glaeser S, Gong J, Gordon-Larsen P, Grallert H, Grammer TB, Grarup N, van Grootheest G, Harald K, Hastie ND, Havulinna AS, Hernandez D, Hindorff L, Hocking LJ, Holmens OL, Holzapfel C, Hottenga JJ, Huang J, Huang T, Hui J, Huth C, Hutri-Kahonen N, James AL, Jansson J-O, Jhun MA, Juonala M, Kinnunen L, Koistinen HA, Kolcic I, Komulainen P, Kuusisto J, Kvaloy K, Kahonen M, Lakka TA, Launer LJ, Lehne B, Lindgren CM, Lorentzon M, Luben R, Marre M, Milaneschi Y, Monda KL, Montgomery GW, De Moor MHM, Mulas A, Mueller-Nurasyid M, Musk AW, Mannikko R, Mannisto S, Narisu N, Nauck M, Nettleton JA, Nolte IM, Oldehinkel AJ, Olden M, Ong KK, Padmanabhan S, Paternoster L, Perez J, Perola M, Peters A, Peters U, Peyser PA, Prokopenko I, Puolijoki H, Raitakari OT, Rankinen T, Rasmussen-Torvik LJ, Rawal R, Ridker PM, Rose LM, Rudan I, Sarti C, Sarzynski MA, Savonen K, Scott WR Set al., 2017, Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults, PLOS GENETICS, Vol: 13, ISSN: 1553-7404

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Graversen L, Howe LD, Sorensen TIA, Sovio U, Hohwu L, Tilling K, Laitinen J, Taanila A, Pouta A, Jarvelin M-R, Obel Cet al., 2017, Body mass index trajectories from 2 to 18years-exploring differences between European cohorts, PEDIATRIC OBESITY, Vol: 12, Pages: 102-109, ISSN: 2047-6310

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Grgic O, Medina-Gomez C, Dhamo B, Trajanoska K, Vucic S, Ongkosuwito EM, Jaddoe VWV, Uitterlinden AG, Jarvelin M-R, Timpson N, Evans DM, Wolvius EB, Rivadeneira Fet al., 2017, Genome-Wide Association Study Identifies Three Novel Genetic Determinants of Dental Maturation., Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), Publisher: WILEY, Pages: S132-S132, ISSN: 0884-0431

CONFERENCE PAPER

January S-AA, Mason WA, Savolainen J, Solomon S, Chmelka MB, Miettunen J, Veijola J, Moilanen I, Taanila A, Jarvelin M-Ret al., 2017, Longitudinal Pathways from Cumulative Contextual Risk at Birth to School Functioning in Adolescence: Analysis of Mediation Effects and Gender Moderation, JOURNAL OF YOUTH AND ADOLESCENCE, Vol: 46, Pages: 180-196, ISSN: 0047-2891

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Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, Ngwa JS, Ahluwalia TS, Chu AY, Heard-Costa NL, Lim E, Perez J, Eicher JD, Kutalik Z, Xue L, Mahajan A, Renstrom F, Wu J, Qi Q, Ahmad S, Alfred T, Amin N, Bielak LF, Bonnefond A, Bragg J, Cadby G, Chittani M, Coggeshall S, Corre T, Direk N, Eriksson J, Fischer K, Gorski M, Harder MN, Horikoshi M, Huang T, Huffman JE, Jackson AU, Justesen JM, Kanoni S, Kinnunen L, Kleber ME, Komulainen P, Kumari M, Lim U, Luan J, Lyytikainen L-P, Mangino M, Manichaikul A, Marten J, Middelberg RPS, Mueller-Nurasyid M, Navarro P, Perusse L, Pervjakova N, Sarti C, Smith AV, Smith JA, Stancakova A, Strawbridge RJ, Stringham HM, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van der Most PJ, Van Vliet-Ostaptchouk JV, Vedantam SL, Verweij N, Vink JM, Vitart V, Wu Y, Yengo L, Zhang W, Zhao JH, Zimmermann ME, Zubair N, Abecasis GR, Adair LS, Afaq S, Afzal U, Bakker SJL, Bartz TM, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Braga D, Buckley BM, Buyske S, Campbell H, Chambers JC, Collins FS, Curran JE, de Borst GJ, de Craen AJM, de Geus EJC, Dedoussis G, Delgado GE, den Ruijter HM, Eiriksdottir G, Eriksson AL, Esko T, Faul JD, Ford I, Forrester T, Gertow K, Gigante B, Glorioso N, Gong J, Grallert H, Grammer TB, Grarup N, Haitjema S, Hallmans G, Hamsten A, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie ND, Heath AC, Hernandez D, Hindorff L, Hocking LJ, Hollensted M, Holmen OL, Homuth G, Hottenga JJ, Huang J, Hung J, Hutri-Kahonen N, Ingelsson E, James AL, Jansson J-O, Jarvelin M-R, Jhun MA, Jorgensen ME, Juonala M, Kahonen M, Karlsson M, Koistinen HA, Kolcic I, Kolovou G, Kooperberg C, Kramer BK, Kuusisto J, Kvaloy K, Lakka TA, Langenberg C, Launer LJ, Leander K, Lee NR, Lind L, Lindgren CM, Linneberg A, Lobbens S, Loh M, Lorentzon M, Luben R, Lubke G, Ludolph-Donislawski A, Lupoli S, Madden PAF, Mannikko R, Marques-Vidalet al., 2017, Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723

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Kaakinen M, Magi R, Fischer K, Heikkinen J, Jarvelin M-R, Morris AP, Prokopenko Iet al., 2017, MARV: a tool for genome-wide multi-phenotype analysis of rare variants, BMC BIOINFORMATICS, Vol: 18, ISSN: 1471-2105

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Kaakinen M, Magi R, Fischer K, Heikkinen J, Jarvelin M-R, Morris AP, Prokopenko Iet al., 2017, A rare-variant test for high-dimensional data, EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 25, Pages: 988-994, ISSN: 1018-4813

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Karjula S, Morin-Papunen L, Auvinen J, Ruokonen A, Puukka K, Franks S, Jarvelin M-R, Tapanainen JS, Jokelainen J, Miettunen J, Piltonen TTet al., 2017, Psychological Distress Is More Prevalent in Fertile Age and Premenopausal Women With PCOS Symptoms: 15-Year Follow-Up, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 102, Pages: 1861-1869, ISSN: 0021-972X

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Kaseva N, Vääräsmäki M, Matinolli H-M, Sipola-Leppänen M, Tikanmäki M, Heinonen K, Lano A, Wolke D, Andersson S, Järvelin M-R, Räikkönen K, Eriksson JG, Kajantie Eet al., 2017, Pre-pregnancy overweight or obesity and gestational diabetes as predictors of body composition in offspring twenty years later: evidence from two birth cohort studies., Int J Obes (Lond)

BACKGROUND: Global prevalence of overweight/obesity and gestational diabetes (GDM) is increasing. In pregnant women both conditions affect offspring's later health. Overweight/obesity is a risk factor of GDM; to what extent maternal overweight/obesity explains long-term effects of GDM in offspring is unknown. OBJECTIVE: To evaluate effects of maternal pre-pregnancy overweight/obesity (body mass index (BMI) ⩾25 kg m-2) and GDM, occurring together or separately, on body composition among adult offspring. METHODS: Participants include 891 individuals aged 24.1 years (s.d. 1.4) from two longitudinal cohort studies (ESTER and AYLS). Adult offspring of normoglycemic mothers with overweight/obesity (ONOO, n=153), offspring of mothers with GDM (OGDM; n=191) and controls (n=547) underwent anthropometric measurements and bioimpedance analysis. Gestational diabetes mellitus was diagnosed by oral glucose tolerance test. Data were analyzed by linear regression models adjusted for confounders. RESULTS: Compared with controls, ONOO-participants showed higher BMI (men 1.64 kg m-2 (95% confidence interval 0.57, 2.72); women 1.41 kg m-2 (0.20, 2.63)) and fat percentage (men 2.70% (0.99, 4.41); women 2.98% (0.87, 5.09)) with larger waist circumferences (men 3.34 cm (0.68, 5.99); women 3.09 cm (0.35, 5.83)). Likewise, OGDM-participants showed higher fat percentage (men 1.97% (0.32, 3.61); women 2.32% (0.24, 4.41)). Body mass index was non-significantly different between OGDM-participants and controls (men 0.88 kg m-2 (-0.17, 1.92); women 0.82 kg m-2 (-0.39, 2.04)). Also waist circumferences were larger (men 2.63 cm (-0.01, 5.28); women 3.39 cm (0.60, 6.18)); this difference was statistically significant in OGDM-women only. Differences in body composition measures were stronger among offspring of women with both GDM and overweight/obesity. For instance, fat mass was higher among OGDM-partic

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Kiviniemi AM, Perkiomaki N, Auvinen J, Niemela M, Tammelin T, Puukka K, Ruokonen A, Keinanen-Kiukaanniemi S, Tulppo MP, Jarvelin M-R, Jamsa T, Huikuri HV, Korpelainen Ret al., 2017, Fitness, Fatness, Physical Activity, and Autonomic Function in Midlife, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Vol: 49, Pages: 2459-2468, ISSN: 0195-9131

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Koot MH, Grooten IJ, Sebert S, Koiranen M, Jarvelin MR, Kajantie E, Painter RC, Roseboom TJet al., 2017, Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow-up of the Northern Finland Birth Cohort 1986, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 124, Pages: 1107-1114, ISSN: 1470-0328

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