922 results found
Palaniswamy S, Piltonen T, Koiranen M, et al., 2019, The association between blood copper concentration and biomarkers related to cardiovascular disease risk - analysis of 206 individuals in the Northern Finland Birth Cohort 1966., J Trace Elem Med Biol, Vol: 51, Pages: 12-18
BACKGROUND: Copper is an abundant trace element in humans where alterations in the circulating concentration could inform on chronic disease aetiology. To date, data are lacking to study how copper may associate with cardiovascular disease (CVD) risk factors in young and healthy population. Molecular evidence suggests an important role of copper in liver metabolism, an essential organ in maintaining cardiovascular health and inflammation, therefore supporting copper as an associated biomarker of the risk. OBJECTIVE: We performed a cross-sectional analysis to examine the possible associations between blood copper levels and risk factors for CVD and pre-inflammatory process. DESIGN: The data has been collected from a sub-sample set of the Northern Finland Birth Cohort 1966 (NFBC1966) at 31 years. PARTICIPANTS: The study included 206 individuals, 116 men and 90 women. To reduce environmental individual variations affecting both copper and the metabolic profile in the study sample, the participants were selected as: i) being born in Finnish Lapland and ii) living in their birth place for the last five years preceding blood sampling. MAIN OUTCOME MEASURES: Fasting blood copper concentration was measured by inductively coupled plasma mass spectrometer. The CVD risk factors included 6 metabolic clusters (30 cardiovascular and pro-inflammatory factors) assessed by nuclear magnetic resonance. Multivariate linear regression analysis was performed to test the linear association between blood copper and 6 metabolic clusters for CVD risk. Associations were assessed under correction for multiple testing. RESULTS: Copper (Cu) levels were comparable in men and women, with no difference between sexes (p-value <0.60). In multiple regression models, sex adjusted, copper was associated with 9 metabolites from 4 metabolic clusters. After adjustment with BMI, copper was associated with 4 metabolites from 3 metabolic clusters: glutamine, beta-hydroxybutyrate, alpha-1-acid glycoprotein
Evangelou E, Warren HR, Mosen-Ansorena D, et al., 2018, Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (vol 50, pg 1412, 2018), NATURE GENETICS, Vol: 50, Pages: 1755-1755, ISSN: 1061-4036
Parmar P, Lowry E, Cugliari G, et al., 2018, Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults, EBIOMEDICINE, Vol: 38, Pages: 206-216, ISSN: 2352-3964
Ollila M-ME, Kaikkonen K, Järvelin M-R, et al., 2018, Self-reported Polycystic Ovary Syndrome is Associated with Hypertension: A Northern Finland Birth Cohort 1966 Study., J Clin Endocrinol Metab
Context: PCOS is associated with many traditional cardiovascular disease risk factors, but it is unclear whether PCOS is an independent risk factor for hypertension. Objective: To investigate in a population-based set-up whether PCOS associates with the risk of hypertension independently of body-mass-index (BMI), and with cardiovascular manifestations. Design: Cross-sectional assessments in the Northern Finland Birth Cohort 1966 at ages 31 and 46. Setting: General community. Participants: Women who reported both oligo/amenorrhea and hirsutism at age 31 and/or diagnosis of PCOS by age 46 (self-reported PCOS [srPCOS], n=279) and women without PCOS symptoms or diagnosis (n=1577). Intervention: None. Main Outcome Measures: Blood pressure (BP), BMI, cardiovascular manifestations. Results: Use of antihypertensive medication was significantly more common in women with srPCOS. At age 31, women with srPCOS had significantly higher systolic (SBP) and diastolic BP (DBP) than control women (SBP: normal-weight: 119.9±13.2 vs. 116.9±11.4mmHg, P=0.017; overweight/obese: 126.1±14.3 vs. 123.0±11.9mmHg, P=0.031; and DBP: normal-weight: 75.5±10.0 vs. 72.4±9.6mmHg, P=0.003; overweight/obese: 80.7±11.8 vs. 78.0±10.6mmHg, P=0.031). At age 46, srPCOS was significantly associated with hypertension (AOR=1.56 [1.14-2.13]) independently of BMI, and with higher cardiovascular morbidity (6.8% vs. 3.4%, P=0.011). Hypertensive srPCOS displayed consistent, unfavorable changes in cardiac structure and function compared with controls. Conclusion: Women with srPCOS displayed higher BP compared with controls already at early age and srPCOS was associated with hypertension independently of overweight/obesity. srPCOS was associated with increased cardiovascular morbidity in premenopausal women, suggesting that cardiovascular disease risk factors should be screened and efficiently managed early enough in women with PCOS.
Smith SB, Parisien M, Bair E, et al., 2018, Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males., Pain
Painful temporomandibular disorders (TMD) is the leading cause of chronic orofacial pain, but its underlying molecular mechanisms remain obscure. While many environmental factors have been associated with higher risk of developing painful TMD, family and twin studies support a heritable genetic component as well. We performed a GWAS assuming an additive genetic model of TMD in a discovery cohort of 999 cases and 2031 TMD-free controls from the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) study. Using logistic models adjusted for sex, age, enrollment site, and race, we identified three distinct loci that were significant in combined or sex-segregated analyses. A single nucleotide polymorphism (SNP) on chromosome 3 (rs13078961) was significantly associated with TMD in males only (odds ratio [OR]=2.9, 95% CI: 2.02-4.27, P=2.2x10). This association was nominally replicated in a meta-analysis of seven independent orofacial pain cohorts including 160,194 participants (OR=1.16, 95% CI: 1.0-1.35, P = 2.3x10). Functional analysis in human dorsal root ganglia (DRG) and blood indicated this variant is an expression quantitative trait locus (eQTL), with the minor allele associated with decreased expression of the nearby muscle RAS oncogene homolog (MRAS) gene (beta = -0.51, P = 2.43x10). Male mice, but not female mice, with a null mutation of Mras displayed persistent mechanical allodynia in a model of inflammatory pain. Genetic and behavioral evidence support a novel mechanism by which genetically-determined MRAS expression moderates the resiliency to chronic pain. This effect is male-specific and may contribute to the lower rates of painful TMD in men.Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a "work of the United States Government" for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to
Ramsay H, Barnett JH, Murray GK, et al., 2018, Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts, PSYCHOLOGICAL MEDICINE, Vol: 48, Pages: 2609-2623, ISSN: 0033-2917
Ramsay H, Barnett JH, Murray GK, et al., 2018, Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts (vol 48, pg 2609, 2018), PSYCHOLOGICAL MEDICINE, Vol: 48, Pages: 2628-2628, ISSN: 0033-2917
Ligthart S, Vaez A, Vosa U, et al., 2018, Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 103, Pages: 691-706, ISSN: 0002-9297
Evensen KAI, Tikanmäki M, Heinonen K, et al., 2018, Musculoskeletal pain in adults born preterm: Evidence from two birth cohort studies., Eur J Pain
BACKGROUND: Individuals born preterm are at risk of later developmental problems and long-term morbidities. There is conflicting evidence regarding musculoskeletal pain in young adulthood. We investigated the prevalence of self-reported musculoskeletal pain in young adults born across the range of preterm birth compared with a term-born reference group. METHODS: From two Finnish birth cohorts, 184 individuals born early preterm (<34 weeks), 350 late preterm (34 to <37 weeks) and 641 at term completed a self-report questionnaire of musculoskeletal pain at mean age 24.1 (SD: 1.4) years. Group differences were examined by logistic regression models adjusting for sex, age and cohort (Model 1), potential early life confounders (Model 2) and lifestyle factors related to physical (Model 3) and mental health (Model 4). RESULTS: The late preterm group had lower odds for reporting neck pain (0.73; 95% confidence interval (CI): 0.56-0.96), which was further reduced when adjusting for early life confounders and lifestyle factors (Model 4). Odds for reporting peripheral pain were 0.69 (95% CI: 0.48-0.99, Model 4) in the early preterm group. The odds for reporting any pain, shoulder, low back or widespread pain did not differ significantly between groups, although odds for reporting widespread pain were 0.77 (95% CI: 0.58-1.03, Model 4) in the late preterm group. CONCLUSIONS: We did not find evidence of increased prevalence of musculoskeletal pain in adults born early or late preterm. In contrast, our results suggest that adults born preterm have a slightly lower risk of reporting musculoskeletal pain, also when we adjusted for lifestyle factors. SIGNIFICANCE: Young adults born preterm do not have increased rates of musculoskeletal pain. Our findings rather suggest that these rates may be slightly lower than among those born at term.
Nedelec R, Jokelainen J, Miettunen J, et al., 2018, Early determinants of metabolically healthy obesity in young adults: study of the Northern Finland Birth Cohort 1966, INTERNATIONAL JOURNAL OF OBESITY, Vol: 42, Pages: 1704-1714, ISSN: 0307-0565
Evangelou E, Warren HR, Mosen-Ansorena D, et al., 2018, Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits, NATURE GENETICS, Vol: 50, Pages: 1412-+, ISSN: 1061-4036
Macare C, Ducci F, Zhang Y, et al., 2018, A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 28, Pages: 1103-1114, ISSN: 0924-977X
Anasanti MD, Kaakinen M, Jarvelin M-R, et al., 2018, Addressing the missing data issue in multi-phenotype genome-wide association studies, 27th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Publisher: WILEY, Pages: 686-686, ISSN: 0741-0395
Draisma H, Kaakinen M, Prelot L, et al., 2018, Epigenome-wide association study of change in body mass index from young- to middle adulthood in 626 northern Finland birth cohort 1966 participants, 27th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Publisher: WILEY, Pages: 724-725, ISSN: 0741-0395
Karhunen V, Wiklund P, Jarvelin M-R, et al., 2018, Joint genetic factors of body mass index and ADHD components, 27th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Publisher: WILEY, Pages: 709-709, ISSN: 0741-0395
Balkhiyarova Z, Kaakinen MA, Draisma HHM, et al., 2018, Dissecting shared pathophysiology of type 2 diabetes and depressive symptoms using multi-phenotype genome-wide association study, 54th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S128-S128, ISSN: 0012-186X
Kaakinen M, Prelot L, Draisma H, et al., 2018, Machine learning in multi-omics data to assess longitudinal predictors of glycaemic trait levels, 27th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Publisher: WILEY, Pages: 709-709, ISSN: 0741-0395
Ramzi NH, Yiorkas AM, Sebert S, et al., 2018, Relationship between BMI and emotion-handling capacity in an adult Finnish population: The Northern Finland Birth Cohort 1966, PLOS ONE, Vol: 13, ISSN: 1932-6203
Waage J, Standl M, Curtin JA, et al., 2018, Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis (vol 50, pg 1072, 2018), NATURE GENETICS, Vol: 50, Pages: 1343-1343, ISSN: 1061-4036
Huels A, Kluemper C, MacIntyre EA, et al., 2018, Atopic dermatitis: Interaction between genetic variants of GSTP1, TNF, TLR2, and TLR4 and air pollution in early life, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 29, Pages: 596-605, ISSN: 0905-6157
Beckmeyer-Borowko A, Imboden M, Rezwan FI, et al., 2018, SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts, RESPIRATORY RESEARCH, Vol: 19, ISSN: 1465-993X
Lowry E, Rautio N, Karhunen V, et al., 2018, Understanding the complexity of glycaemic health: systematic bio-psychosocial modelling of fasting glucose in middle-age adults; a DynaHEALTH study., Int J Obes (Lond)
BACKGROUND: The prevention of the risk of type 2 diabetes (T2D) is complicated by multidimensional interplays between biological and psychosocial factors acting at the individual level. To address the challenge we took a systematic approach, to explore the bio-psychosocial predictors of blood glucose in mid-age. METHODS: Based on the 31-year and 46-year follow-ups (5,078 participants, 43% male) of Northern Finland Birth Cohort 1966, we used a systematic strategy to select bio-psychosocial variables at 31 years to enable a data-driven approach. As selection criteria, the variable must be (i) a component of the metabolic syndrome or an indicator of psychosocial health using WHO guidelines, (ii) easily obtainable in general health check-ups and (iii) associated with fasting blood glucose at 46 years (P < 0.10). Exploratory and confirmatory factor analysis were used to derive latent factors, and stepwise linear regression allowed exploration of relationships between factors and fasting glucose. RESULTS: Of all 26 variables originally considered, 19 met the selection criteria and were included in an exploratory factor analysis. Two variables were further excluded due to low loading (<0.3). We derived four latent factors, which we named as socioeconomic, metabolic, psychosocial and blood pressure status. The combination of metabolic and psychosocial factors, adjusted for sex, provided best prediction of fasting glucose at 46 years (explaining 10.7% of variation in glucose; P < 0.001). Regarding different bio-psychosocial pathways and relationships, the importance of psychosocial factors in addition to established metabolic risk factors was highlighted. CONCLUSIONS: The present study supports evidence for the bio-psychosocial nature of adult glycemic health and exemplifies an evidence-based approach to model the bio-psychosocial relationships. The factorial model may help further research and public health practice in focusing also on p
Lee JJ, Wedow R, Okbay A, et al., 2018, Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals, NATURE GENETICS, Vol: 50, Pages: 1112-+, ISSN: 1061-4036
Waage J, Standl M, Curtin JA, et al., 2018, Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis, NATURE GENETICS, Vol: 50, Pages: 1072-+, ISSN: 1061-4036
Yang Y, Zhao H, Boomsma DI, et al., 2018, Molecular genetic overlap between migraine and major depressive disorder., Eur J Hum Genet, Vol: 26, Pages: 1202-1216
Migraine and major depressive disorder (MDD) are common brain disorders that frequently co-occur. Despite epidemiological evidence that migraine and MDD share a genetic basis, their overlap at the molecular genetic level has not been thoroughly investigated. Using single-nucleotide polymorphism (SNP) and gene-based analysis of genome-wide association study (GWAS) genotype data, we found significant genetic overlap across the two disorders. LD Score regression revealed a significant SNP-based heritability for both migraine (h2 = 12%) and MDD (h2 = 19%), and a significant cross-disorder genetic correlation (rG = 0.25; P = 0.04). Meta-analysis of results for 8,045,569 SNPs from a migraine GWAS (comprising 30,465 migraine cases and 143,147 control samples) and the top 10,000 SNPs from a MDD GWAS (comprising 75,607 MDD cases and 231,747 healthy controls), implicated three SNPs (rs146377178, rs672931, and rs11858956) with novel genome-wide significant association (PSNP ≤ 5 × 10-8) to migraine and MDD. Moreover, gene-based association analyses revealed significant enrichment of genes nominally associated (Pgene-based ≤ 0.05) with both migraine and MDD (Pbinomial-test = 0.001). Combining results across migraine and MDD, two genes, ANKDD1B and KCNK5, produced Fisher's combined gene-based P values that surpassed the genome-wide significance threshold (PFisher's-combined ≤ 3.6 × 10-6). Pathway analysis of genes with PFisher's-combined ≤ 1 × 10-3 suggested several pathways, foremost neural-related pathways of signalling and ion channel regulation, to be involved in migraine and MDD aetiology. In conclusion, our study provides strong molecular genetic support for shared genetically determined biological mechanisms underlying migraine and MDD.
Pluymen LPM, Wijga AH, Gehring U, et al., 2018, Early introduction of complementary foods and childhood overweight in breastfed and formula-fed infants in the Netherlands: the PIAMA birth cohort study., Eur J Nutr, Vol: 57, Pages: 1985-1993
PURPOSE: To investigate whether early introduction of complementary foods (CF) is associated with an increased risk of overweight during childhood, and whether this association differs between formula-fed and breastfed infants. METHODS: We included 2611 participants that were born at term from a Dutch population-based birth cohort (n = 3963) designed to investigate the development of asthma and allergies. Parents kept records of their infant's age when CF were first introduced. Weight and height were parent reported yearly from age 1 to 8 years, and at ages 11, 14 and 17 years. We used multivariate generalized estimating equations analysis to investigate the association between timing of CF introduction (before 4 months vs at or after 4 months of age) and overweight at ages 1-17 years. RESULTS: Children with CF introduction before 4 months had higher odds of being overweight during childhood than children with CF introduction at or after 4 months (OR 1.32, 95% CI 1.19, 1.47). This association was observed in formula-fed infants (OR 1.51, 95% CI 1.17, 1.94) and breastfed infants (OR 1.32, 95% CI 1.19, 1.47). The duration of breastfeeding modified the association between CF introduction and overweight: children breastfed for shorter than 4 months, but not children breastfed for 4 months or longer with CF introduction before 4 months had higher odds of being overweight (OR 1.37, 95% CI 1.19, 1.57 and 1.07, 95% CI 0.87, 1.32, respectively), compared to those with CF introduction at or after 4 months. CONCLUSIONS: In children born at term, formula-fed infants and infants who were breastfed for shorter than 4 months, but not infants who were breastfed for 4 months or longer, had a higher risk of being overweight during childhood when being introduced to CF before 4 months of age.
, 2018, Prediction of the severity of allergic reactions to foods, Allergy: European Journal of Allergy and Clinical Immunology, Vol: 73, Pages: 1532-1540, ISSN: 0105-4538
© 2018 The Authors. Allergy published by John Wiley & Sons Ltd. Background: There is currently considerable uncertainty regarding what the predictors of the severity of diagnostic or accidental food allergic reactions are, and to what extent the severity of such reactions can be predicted. Objective: To identify predictors for the severity of diagnostic and accidental food allergic reactions and to quantify their impact. Methods: The study population consisted of children with a double-blind, placebo-controlled food challenge (DBPCFC)–confirmed food allergy to milk, egg, peanut, cashew nut, and/or hazelnut. The data were analyzed using multiple linear regression analysis. Missing values were imputed using multiple imputation techniques. Two scoring systems were used to determine the severity of the reactions. Results: A total of 734 children were included. Independent predictors for the severity of the DBPCFC reaction were age (B = 0.04, P =.001), skin prick test ratio (B = 0.30, P <.001), eliciting dose (B = −0.09, P <.001), level of specific immunoglobulin E (B = 0.15, P <.001), reaction time during the DBPCFC (B = −0.01, P =.004), and severity of accidental reaction (B = 0.08, P =.015). The total explained variance of this model was 23.5%, and the eliciting dose only contributed 4.4% to the model. Independent predictors for more severe accidental reactions with an explained variance of 7.3% were age (B = 0.03, P =.014), milk as causative food (B = 0.77, P <.001), cashew as causative food (B = 0.54, P <.001), history of atopic dermatitis (B = −0.47, P =.006), and severity of DBPCFC reaction (B = 0.12, P =.003). Conclusions: The severity of DBPCFCs and accidental reactions to food remains largely unpredictable. Clinicians should not use the eliciting dose obtained from a graded food challenge for the purposes of making risk-related management decisions.
Karjula S, Morin-Papunen L, Auvinen J, et al., 2018, Long-term health related quality of life (HRQoL), life satisfaction and health status in women with PCOS-a population-based follow-up analysis at ages 31 and 46, 34th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 444-445, ISSN: 0268-1161
Laru J, Nedelec R, Ojaniemi M, et al., 2018, Childhood and adolescence body mass index associates with impaired reproductive function - a prospective, population-based cohort study, 34th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 448-449, ISSN: 0268-1161
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.