Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3345m.jarvelin

 
 
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Location

 

156Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Waage:2018:10.1038/s41588-018-0157-1,
author = {Waage, J and Standl, M and Curtin, JA and Jessen, L and Thorsen, J and The, 23andMe Research Team and AAGC, Collaborators and Abdellaoui, A and Ahluwalia, TS and Alves, A and Amaral, AFS and Anto, JM and Arnold, A and Flores, C and Baurecht, H and Beijstervedldt, TCEM and Bleecker, ER and Bonas-Guarch, S and Boomsma, D and Brix, S and Bunyavanich, S and Burchard, E and Chen, Z and Curjuric, I and Custovic, A and den, Dekker M and Dharmage, SC and Dmitrieva, J and Duijts, L and Ege, M and Barreto-Luis, A and Gauderman, WJ and Georges, M and Gieger, C and Gilliland, F and Granell, R and Gui, H and Hansen, T and Heinrich, J and Henderson, J and Hernandez-Pacheco, N and Hinds, DA and Holt, P and Imboden, M and Jaddoe, V and Jarvelin, M and Jarvis, D and Jensen, KK and Jonsdottir, I and Kabesch, M and Kaprio, J and Kumar, A and Lee, Y and Levin, AM and Li, X and Lorenz-Diaz, F and Melen, E and Mercader, JM and Meyers, DA and Nicolae, DL and Nohr, E and Palvianinen, T and Paternoster, L and },
doi = {10.1038/s41588-018-0157-1},
journal = {Nature Genetics},
pages = {1072--1080},
title = {Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis},
url = {http://dx.doi.org/10.1038/s41588-018-0157-1},
volume = {50},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, and with increasing incidence in westernized countries.1,2  To elucidate the genetic architecture and understand disease mechanisms of allergic rhinitis, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implied genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants of importance for antigen binding. We further performed GWASs of allergic sensitization against inhalant allergens and non-allergic rhinitis suggesting shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis.
AU  - Waage,J
AU  - Standl,M
AU  - Curtin,JA
AU  - Jessen,L
AU  - Thorsen,J
AU  - The,23andMe Research Team
AU  - AAGC,Collaborators
AU  - Abdellaoui,A
AU  - Ahluwalia,TS
AU  - Alves,A
AU  - Amaral,AFS
AU  - Anto,JM
AU  - Arnold,A
AU  - Flores,C
AU  - Baurecht,H
AU  - Beijstervedldt,TCEM
AU  - Bleecker,ER
AU  - Bonas-Guarch,S
AU  - Boomsma,D
AU  - Brix,S
AU  - Bunyavanich,S
AU  - Burchard,E
AU  - Chen,Z
AU  - Curjuric,I
AU  - Custovic,A
AU  - den,Dekker M
AU  - Dharmage,SC
AU  - Dmitrieva,J
AU  - Duijts,L
AU  - Ege,M
AU  - Barreto-Luis,A
AU  - Gauderman,WJ
AU  - Georges,M
AU  - Gieger,C
AU  - Gilliland,F
AU  - Granell,R
AU  - Gui,H
AU  - Hansen,T
AU  - Heinrich,J
AU  - Henderson,J
AU  - Hernandez-Pacheco,N
AU  - Hinds,DA
AU  - Holt,P
AU  - Imboden,M
AU  - Jaddoe,V
AU  - Jarvelin,M
AU  - Jarvis,D
AU  - Jensen,KK
AU  - Jonsdottir,I
AU  - Kabesch,M
AU  - Kaprio,J
AU  - Kumar,A
AU  - Lee,Y
AU  - Levin,AM
AU  - Li,X
AU  - Lorenz-Diaz,F
AU  - Melen,E
AU  - Mercader,JM
AU  - Meyers,DA
AU  - Nicolae,DL
AU  - Nohr,E
AU  - Palvianinen,T
AU  - Paternoster,L
AU  - Pennell,C
AU  - Pershagen,G
AU  - Pino-Yanes,M
AU  - Probst-Hensch,NM
AU  - Ruschendorf,F
AU  - Schoettler,N
AU  - Simpson,A
AU  - Stefansson,K
AU  - Sunyer,J
AU  - Sveinbjornsson,G
AU  - Thiering,E
AU  - Thompson,PJ
AU  - Tian,C
AU  - Torrent,M
AU  - Torrents,D
AU  - Tung,JY
AU  - Wang,C
AU  - Weidinger,S
AU  - Weiss,S
AU  - Willemsen,G
AU  - Williams,LK
AU  - Ober,C
AU  - Ferreira,MA
AU  - Bisgaard,H
AU  - Strachan,D
AU  - Bonnelykke,K
DO  - 10.1038/s41588-018-0157-1
EP  - 1080
PY  - 2018///
SN  - 1061-4036
SP  - 1072
TI  - Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/s41588-018-0157-1
UR  - https://www.nature.com/articles/s41588-018-0157-1
UR  - http://hdl.handle.net/10044/1/60029
VL  - 50
ER  -
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