Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3345m.jarvelin

 
 
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Location

 

156Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Palaniswamy:2019:10.1016/j.jtemb.2018.09.003,
author = {Palaniswamy, S and Piltonen, T and Koiranen, M and Mazej, D and Järvelin, M-R and Abass, K and Rautio, A and Sebert, S},
doi = {10.1016/j.jtemb.2018.09.003},
journal = {Journal of Trace Elements in Medicine and Biology},
pages = {12--18},
title = {The association between blood copper concentration and biomarkers related to cardiovascular disease risk - analysis of 206 individuals in the Northern Finland Birth Cohort 1966},
url = {http://dx.doi.org/10.1016/j.jtemb.2018.09.003},
volume = {51},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Copper is an abundant trace element in humans where alterations in the circulating concentration could inform on chronic disease aetiology. To date, data are lacking to study how copper may associate with cardiovascular disease (CVD) risk factors in young and healthy population. Molecular evidence suggests an important role of copper in liver metabolism, an essential organ in maintaining cardiovascular health and inflammation, therefore supporting copper as an associated biomarker of the risk. OBJECTIVE: We performed a cross-sectional analysis to examine the possible associations between blood copper levels and risk factors for CVD and pre-inflammatory process. DESIGN: The data has been collected from a sub-sample set of the Northern Finland Birth Cohort 1966 (NFBC1966) at 31 years. PARTICIPANTS: The study included 206 individuals, 116 men and 90 women. To reduce environmental individual variations affecting both copper and the metabolic profile in the study sample, the participants were selected as: i) being born in Finnish Lapland and ii) living in their birth place for the last five years preceding blood sampling. MAIN OUTCOME MEASURES: Fasting blood copper concentration was measured by inductively coupled plasma mass spectrometer. The CVD risk factors included 6 metabolic clusters (30 cardiovascular and pro-inflammatory factors) assessed by nuclear magnetic resonance. Multivariate linear regression analysis was performed to test the linear association between blood copper and 6 metabolic clusters for CVD risk. Associations were assessed under correction for multiple testing. RESULTS: Copper (Cu) levels were comparable in men and women, with no difference between sexes (p-value <0.60). In multiple regression models, sex adjusted, copper was associated with 9 metabolites from 4 metabolic clusters. After adjustment with BMI, copper was associated with 4 metabolites from 3 metabolic clusters: glutamine, beta-hydroxybutyrate, alpha-1-acid glycoprotein
AU  - Palaniswamy,S
AU  - Piltonen,T
AU  - Koiranen,M
AU  - Mazej,D
AU  - Järvelin,M-R
AU  - Abass,K
AU  - Rautio,A
AU  - Sebert,S
DO  - 10.1016/j.jtemb.2018.09.003
EP  - 18
PY  - 2019///
SN  - 0946-672X
SP  - 12
TI  - The association between blood copper concentration and biomarkers related to cardiovascular disease risk - analysis of 206 individuals in the Northern Finland Birth Cohort 1966
T2  - Journal of Trace Elements in Medicine and Biology
UR  - http://dx.doi.org/10.1016/j.jtemb.2018.09.003
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30466920
UR  - http://hdl.handle.net/10044/1/64933
VL  - 51
ER  -
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