Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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m.jarvelin

 
 
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302School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nasanen-Gilmore:2018:10.1371/journal.pone.0205979,
author = {Nasanen-Gilmore, P and Sipola-Leppanen, M and Tikanmaki, M and Matinolli, H-M and Eriksson, JG and Jarvelin, M-R and Vaarasmaki, M and Hovi, P and Kajantie, E},
doi = {10.1371/journal.pone.0205979},
journal = {PLoS One},
pages = {1--15},
title = {Lung function in adults born preterm},
url = {http://dx.doi.org/10.1371/journal.pone.0205979},
volume = {13},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Very preterm birth, before the gestational age (GA) of 32 weeks, increases the risk of obstructed airflow in adulthood. We examined whether all preterm births (GA<37 weeks) are associated with poorer adult lung function and whether any associations are explained by maternal, early life/neonatal, or current life factors. Participants of the ESTER Preterm Birth Study, born between 1985 and 1989 (during the pre-surfactant era), at the age of 23 years participated in a clinical study in which they performed spirometry and provided detailed medical history. Of the participants, 139 were born early preterm (GA<34 weeks), 239 late preterm (GA: 34-<37 weeks), and 341 full-term (GA≥37 weeks). Preterm birth was associated with poorer lung function. Mean differences between individuals born early preterm versus full-term were -0.23 standard deviation (SD) (95% confidence interval (CI): -0.40, -0.05)) for forced vital capacity z-score (zFVC), -0.44 SD (95% CI -0.64, -0.25) for forced expiratory volume z-score (zFEV1), and -0.29 SD (95% CI -0.47, -0.10) for zFEV1/FVC. For late preterm, mean differences with full-term controls were -0.02 SD (95% CI -0.17, 0.13), -0.12 SD (95% CI -0.29, 0.04) and -0.13 SD (95% CI -0.29, 0.02) for zFVC, zFEV1, and zFEV1/FVC, respectively. Examination of finer GA subgroups suggested an inverse non-linear association between lung function and GA, with the greatest impact on zFEV1 for those born extremely preterm. The subgroup means were GA<28 weeks: -0.98 SD; 28-<32 weeks: -0.29 SD; 32-<34 weeks: -0.44 SD; 34-<36 weeks: -0.10 SD; 36-<37weeks: -0.11 SD; term-born controls (≥37weeks): 0.02 SD. Corresponding means for zFEV1/FVC were -1.79, -0.44, -0.47, -0.48, -0.29, and -0.02. Adjustment for maternal pregnancy conditions and socioeconomic and lifestyle factors had no major impact on the relationship. Preterm birth is associated with airflow limitation in adult life. The association appears to be attributable predominantly
AU  - Nasanen-Gilmore,P
AU  - Sipola-Leppanen,M
AU  - Tikanmaki,M
AU  - Matinolli,H-M
AU  - Eriksson,JG
AU  - Jarvelin,M-R
AU  - Vaarasmaki,M
AU  - Hovi,P
AU  - Kajantie,E
DO  - 10.1371/journal.pone.0205979
EP  - 15
PY  - 2018///
SN  - 1932-6203
SP  - 1
TI  - Lung function in adults born preterm
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0205979
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000447761400030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205979
UR  - http://hdl.handle.net/10044/1/85446
VL  - 13
ER  -
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