Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3345m.jarvelin

 
 
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Location

 

156Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kreiner:2017:10.1016/j.jaci.2016.10.055,
author = {Kreiner, E and Waage, J and Standl, M and Brix, S and Pers, TH and Couto, Alves A and Warrington, NM and Tiesler, CM and Fuertes, E and Franke, L and Hirschhorn, JN and James, A and Simpson, A and Tung, JY and Koppelman, GH and Postma, DS and Pennell, CE and Jarvelin, MR and Custovic, A and Timpson, N and Ferreira, MA and Strachan, DP and Henderson, J and Hinds, D and Bisgaard, H and Bønnelykke, K},
doi = {10.1016/j.jaci.2016.10.055},
journal = {Journal of Allergy and Clinical Immunology},
pages = {771--781},
title = {Shared genetic variants suggest common pathways in allergy and autoimmune diseases.},
url = {http://dx.doi.org/10.1016/j.jaci.2016.10.055},
volume = {140},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The relationship between allergy and autoimmune disorders is complex and poorly understood. OBJECTIVE: We sought to investigate commonalities in genetic loci and pathways between allergy and autoimmune diseases to elucidate shared disease mechanisms. METHODS: We meta-analyzed 2 genome-wide association studies on self-reported allergy and sensitization comprising a total of 62,330 subjects. These results were used to calculate enrichment for single nucleotide polymorphisms (SNPs) previously associated with autoimmune diseases. Furthermore, we probed for enrichment within genetic pathways and of transcription factor binding sites and characterized commonalities in variant burden on tissue-specific regulatory sites by calculating the enrichment of allergy SNPs falling in gene regulatory regions in various cells using Encode Roadmap DNase-hypersensitive site data. Finally, we compared the allergy data with those of all known diseases. RESULTS: Among 290 loci previously associated with 16 autoimmune diseases, we found a significant enrichment of loci also associated with allergy (P = 1.4e-17) encompassing 29 loci at a false discovery rate of less than 0.05. Such enrichment seemed to be a general characteristic for autoimmune diseases. Among the common loci, 48% had the same direction of effect for allergy and autoimmune diseases. Additionally, we observed an enrichment of allergy SNPs falling within immune pathways and regions of chromatin accessible in immune cells that was also represented in patients with autoimmune diseases but not those with other diseases. CONCLUSION: We identified shared susceptibility loci and commonalities in pathways between allergy and autoimmune diseases, suggesting shared disease mechanisms. Further studies of these shared genetic mechanisms might help in understanding the complex relationship between these diseases, including the parallel increase in disease prevalence.
AU  - Kreiner,E
AU  - Waage,J
AU  - Standl,M
AU  - Brix,S
AU  - Pers,TH
AU  - Couto,Alves A
AU  - Warrington,NM
AU  - Tiesler,CM
AU  - Fuertes,E
AU  - Franke,L
AU  - Hirschhorn,JN
AU  - James,A
AU  - Simpson,A
AU  - Tung,JY
AU  - Koppelman,GH
AU  - Postma,DS
AU  - Pennell,CE
AU  - Jarvelin,MR
AU  - Custovic,A
AU  - Timpson,N
AU  - Ferreira,MA
AU  - Strachan,DP
AU  - Henderson,J
AU  - Hinds,D
AU  - Bisgaard,H
AU  - Bønnelykke,K
DO  - 10.1016/j.jaci.2016.10.055
EP  - 781
PY  - 2017///
SN  - 1097-6825
SP  - 771
TI  - Shared genetic variants suggest common pathways in allergy and autoimmune diseases.
T2  - Journal of Allergy and Clinical Immunology
UR  - http://dx.doi.org/10.1016/j.jaci.2016.10.055
UR  - http://hdl.handle.net/10044/1/45543
VL  - 140
ER  -
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