Imperial College London
Portrait Picture

ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
//

Contact

 

m.jarvelin

 
 
//

Location

 

302School of Public HealthWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Justice:2017:10.1038/ncomms14977,
author = {Justice, AE and Winkler, TW and Feitosa, MF and Graff, M and Fisher, VA and Young, K and Barata, L and Deng, X and Czajkowski, J and Hadley, D and Ngwa, JS and Ahluwalia, TS and Chu, AY and Heard-Costa, NL and Lim, E and Perez, J and Eicher, JD and Kutalik, Z and Xue, L and Mahajan, A and Renstrom, F and Wu, J and Qi, Q and Ahmad, S and Alfred, T and Amin, N and Bielak, LF and Bonnefond, A and Bragg, J and Cadby, G and Chittani, M and Coggeshall, S and Corre, T and Direk, N and Eriksson, J and Fischer, K and Gorski, M and Harder, MN and Horikoshi, M and Huang, T and Huffman, JE and Jackson, AU and Justesen, JM and Kanoni, S and Kinnunen, L and Kleber, ME and Komulainen, P and Kumari, M and Lim, U and Luan, J and Lyytikainen, L-P and Mangino, M and Manichaikul, A and Marten, J and Middelberg, RPS and Mueller-Nurasyid, M and Navarro, P and Perusse, L and Pervjakova, N and Sarti, C and Smith, AV and Smith, JA and Stancakova, A and Strawbridge, RJ and Stringham, HM and Sung, YJ and Tanaka,},
doi = {10.1038/ncomms14977},
journal = {NATURE COMMUNICATIONS},
title = {Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits},
url = {http://dx.doi.org/10.1038/ncomms14977},
volume = {8},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
AU  - Justice,AE
AU  - Winkler,TW
AU  - Feitosa,MF
AU  - Graff,M
AU  - Fisher,VA
AU  - Young,K
AU  - Barata,L
AU  - Deng,X
AU  - Czajkowski,J
AU  - Hadley,D
AU  - Ngwa,JS
AU  - Ahluwalia,TS
AU  - Chu,AY
AU  - Heard-Costa,NL
AU  - Lim,E
AU  - Perez,J
AU  - Eicher,JD
AU  - Kutalik,Z
AU  - Xue,L
AU  - Mahajan,A
AU  - Renstrom,F
AU  - Wu,J
AU  - Qi,Q
AU  - Ahmad,S
AU  - Alfred,T
AU  - Amin,N
AU  - Bielak,LF
AU  - Bonnefond,A
AU  - Bragg,J
AU  - Cadby,G
AU  - Chittani,M
AU  - Coggeshall,S
AU  - Corre,T
AU  - Direk,N
AU  - Eriksson,J
AU  - Fischer,K
AU  - Gorski,M
AU  - Harder,MN
AU  - Horikoshi,M
AU  - Huang,T
AU  - Huffman,JE
AU  - Jackson,AU
AU  - Justesen,JM
AU  - Kanoni,S
AU  - Kinnunen,L
AU  - Kleber,ME
AU  - Komulainen,P
AU  - Kumari,M
AU  - Lim,U
AU  - Luan,J
AU  - Lyytikainen,L-P
AU  - Mangino,M
AU  - Manichaikul,A
AU  - Marten,J
AU  - Middelberg,RPS
AU  - Mueller-Nurasyid,M
AU  - Navarro,P
AU  - Perusse,L
AU  - Pervjakova,N
AU  - Sarti,C
AU  - Smith,AV
AU  - Smith,JA
AU  - Stancakova,A
AU  - Strawbridge,RJ
AU  - Stringham,HM
AU  - Sung,YJ
AU  - Tanaka,T
AU  - Teumer,A
AU  - Trompet,S
AU  - van,der Laan SW
AU  - van,der Most PJ
AU  - Van,Vliet-Ostaptchouk JV
AU  - Vedantam,SL
AU  - Verweij,N
AU  - Vink,JM
AU  - Vitart,V
AU  - Wu,Y
AU  - Yengo,L
AU  - Zhang,W
AU  - Zhao,JH
AU  - Zimmermann,ME
AU  - Zubair,N
AU  - Abecasis,GR
AU  - Adair,LS
AU  - Afaq,S
AU  - Afzal,U
AU  - Bakker,SJL
AU  - Bartz,TM
AU  - Beilby,J
AU  - Bergman,RN
AU  - Bergmann,S
AU  - Biffar,R
AU  - Blangero,J
AU  - Boerwinkle,E
AU  - Bonnycastle,LL
AU  - Bottinger,E
AU  - Braga,D
AU  - Buckley,BM
AU  - Buyske,S
AU  - Campbell,H
AU  - Chambers,JC
AU  - Collins,FS
AU  - Curran,JE
AU  - de,Borst GJ
AU  - de,Craen AJM
AU  - de,Geus EJC
AU  - Dedoussis,G
AU  - Delgado,GE
AU  - den,Ruijter HM
AU  - Eiriksdottir,G
AU  - Eriksson,AL
AU  - Esko,T
AU  - Faul,JD
AU  - Ford,I
AU  - Forrester,T
AU  - Gertow,K
AU  - Gigante,B
AU  - Glorioso,N
AU  - Gong,J
AU  - Grallert,H
AU  - Grammer,TB
AU  - Grarup,N
AU  - Haitjema,S
AU  - Hallmans,G
AU  - Hamsten,A
AU  - Hansen,T
AU  - Harris,TB
AU  - Hartman,CA
AU  - Hassinen,M
AU  - Hastie,ND
AU  - Heath,AC
AU  - Hernandez,D
AU  - Hindorff,L
AU  - Hocking,LJ
AU  - Hollensted,M
AU  - Holmen,OL
AU  - Homuth,G
AU  - Hottenga,JJ
AU  - Huang,J
AU  - Hung,J
AU  - Hutri-Kahonen,N
AU  - Ingelsson,E
AU  - James,AL
AU  - Jansson,J-O
AU  - Jarvelin,M-R
AU  - Jhun,MA
AU  - Jorgensen,ME
AU  - Juonala,M
AU  - Kahonen,M
AU  - Karlsson,M
AU  - Koistinen,HA
AU  - Kolcic,I
AU  - Kolovou,G
AU  - Kooperberg,C
AU  - Kramer,BK
AU  - Kuusisto,J
AU  - Kvaloy,K
AU  - Lakka,TA
AU  - Langenberg,C
AU  - Launer,LJ
AU  - Leander,K
AU  - Lee,NR
AU  - Lind,L
AU  - Lindgren,CM
AU  - Linneberg,A
AU  - Lobbens,S
AU  - Loh,M
AU  - Lorentzon,M
AU  - Luben,R
AU  - Lubke,G
AU  - Ludolph-Donislawski,A
AU  - Lupoli,S
AU  - Madden,PAF
AU  - Mannikko,R
AU  - Marques-Vidal
DO  - 10.1038/ncomms14977
PY  - 2017///
SN  - 2041-1723
TI  - Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
T2  - NATURE COMMUNICATIONS
UR  - http://dx.doi.org/10.1038/ncomms14977
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000400064600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48670
VL  - 8
ER  -
Download