Imperial College London
Portrait Picture

ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
//

Contact

 

m.jarvelin

 
 
//

Location

 

302School of Public HealthWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Demenais:2017:10.1038/s41588-017-0014-7,
author = {Demenais, F and Margaritte-Jeannin, P and Barnes, KC and Cookson, WOC and Altmüller, J and Ang, W and Barr, RG and Beaty, TH and Becker, AB and Beilby, J and Bisgaard, H and Bjornsdottir, US and Bleecker, E and Bønnelykke, K and Boomsma, DI and Bouzigon, E and Brightling, CE and Brossard, M and Brusselle, GG and Burchard, E and Burkart, KM and Bush, A and Chan-Yeung, M and Chung, KF and Couto, Alves A and Curtin, JA and Custovic, A and Daley, D and de, Jongste JC and Del-Rio-Navarro, BE and Donohue, KM and Duijts, L and Eng, C and Eriksson, JG and Farrall, M and Fedorova, Y and Feenstra, B and Ferreira, MA and Australian, Asthma Genetics Consortium AAGC collaborators and Freidin, MB and Gajdos, Z and Gauderman, J and Gehring, U and Geller, F and Genuneit, J and Gharib, SA and Gilliland, F and Granell, R and Graves, PE and Gudbjartsson, DF and Haahtela, T and Heckbert, SR and Heederik, D and Heinrich, J and Heliövaara, M and Henderson, J and Himes, BE and Hirose, H and Hirschhorn, JN an},
doi = {10.1038/s41588-017-0014-7},
journal = {Nature Genetics},
pages = {42--53},
title = {Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks},
url = {http://dx.doi.org/10.1038/s41588-017-0014-7},
volume = {50},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
AU  - Demenais,F
AU  - Margaritte-Jeannin,P
AU  - Barnes,KC
AU  - Cookson,WOC
AU  - Altmüller,J
AU  - Ang,W
AU  - Barr,RG
AU  - Beaty,TH
AU  - Becker,AB
AU  - Beilby,J
AU  - Bisgaard,H
AU  - Bjornsdottir,US
AU  - Bleecker,E
AU  - Bønnelykke,K
AU  - Boomsma,DI
AU  - Bouzigon,E
AU  - Brightling,CE
AU  - Brossard,M
AU  - Brusselle,GG
AU  - Burchard,E
AU  - Burkart,KM
AU  - Bush,A
AU  - Chan-Yeung,M
AU  - Chung,KF
AU  - Couto,Alves A
AU  - Curtin,JA
AU  - Custovic,A
AU  - Daley,D
AU  - de,Jongste JC
AU  - Del-Rio-Navarro,BE
AU  - Donohue,KM
AU  - Duijts,L
AU  - Eng,C
AU  - Eriksson,JG
AU  - Farrall,M
AU  - Fedorova,Y
AU  - Feenstra,B
AU  - Ferreira,MA
AU  - Australian,Asthma Genetics Consortium AAGC collaborators
AU  - Freidin,MB
AU  - Gajdos,Z
AU  - Gauderman,J
AU  - Gehring,U
AU  - Geller,F
AU  - Genuneit,J
AU  - Gharib,SA
AU  - Gilliland,F
AU  - Granell,R
AU  - Graves,PE
AU  - Gudbjartsson,DF
AU  - Haahtela,T
AU  - Heckbert,SR
AU  - Heederik,D
AU  - Heinrich,J
AU  - Heliövaara,M
AU  - Henderson,J
AU  - Himes,BE
AU  - Hirose,H
AU  - Hirschhorn,JN
AU  - Hofman,A
AU  - Holt,P
AU  - Hottenga,J
AU  - Hudson,TJ
AU  - Hui,J
AU  - Imboden,M
AU  - Ivanov,V
AU  - Jaddoe,VWV
AU  - James,A
AU  - Janson,C
AU  - Jarvelin,M-R
AU  - Jarvis,D
AU  - Jones,G
AU  - Jonsdottir,I
AU  - Jousilahti,P
AU  - Kabesch,M
AU  - Kähönen,M
AU  - Kantor,DB
AU  - Karunas,AS
AU  - Khusnutdinova,E
AU  - Koppelman,GH
AU  - Kozyrskyj,AL
AU  - Kreiner,E
AU  - Kubo,M
AU  - Kumar,R
AU  - Kumar,A
AU  - Kuokkanen,M
AU  - Lahousse,L
AU  - Laitinen,T
AU  - Laprise,C
AU  - Lathrop,M
AU  - Lau,S
AU  - Lee,Y-A
AU  - Lehtimäki,T
AU  - Letort,S
AU  - Levin,AM
AU  - Li,G
AU  - Liang,L
AU  - Loehr,LR
AU  - London,SJ
AU  - Loth,DW
AU  - Manichaikul,A
AU  - Marenholz,I
AU  - Martinez,FJ
AU  - Matheson,MC
AU  - Mathias,RA
AU  - Matsumoto,K
AU  - Mbarek,H
AU  - McArdle,WL
AU  - Melbye,M
AU  - Melén,E
AU  - Meyers,D
AU  - Michel,S
AU  - Mohamdi,H
AU  - Musk,AW
AU  - Myers,RA
AU  - Nieuwenhuis,MAE
AU  - Noguchi,E
AU  - O'Connor,GT
AU  - Ogorodova,LM
AU  - Palmer,CD
AU  - Palotie,A
AU  - Park,JE
AU  - Pennell,CE
AU  - Pershagen,G
AU  - Polonikov,A
AU  - Postma,DS
AU  - Probst-Hensch,N
AU  - Puzyrev,VP
AU  - Raby,BA
AU  - Raitakari,OT
AU  - Ramasamy,A
AU  - Rich,SS
AU  - Robertson,CF
AU  - Romieu,I
AU  - Salam,MT
AU  - Salomaa,V
AU  - Schlünssen,V
AU  - Scott,R
AU  - Selivanova,PA
AU  - Sigsgaard,T
AU  - Simpson,A
AU  - Siroux,V
AU  - Smith,LJ
AU  - Solodilova,M
AU  - Standl,M
AU  - Stefansson,K
AU  - Strachan,DP
AU  - Stricker,BH
AU  - Takahashi,A
AU  - Thompson,PJ
AU  - Thorleifsson,G
AU  - Thorsteinsdottir,U
AU  - Tiesler,CMT
AU  - Torgerson,DG
AU  - Tsunoda,T
AU  - Uitterlinden,AG
AU  - van,der Valk RJP
AU  - Vaysse,A
AU  - Vedantam,S
AU  - von,Berg A
AU  - von,Mutius E
AU  - Vonk,JM
AU  - Waage,J
AU  - Wareham,NJ
AU  - Weiss,ST
DO  - 10.1038/s41588-017-0014-7
EP  - 53
PY  - 2017///
SN  - 1061-4036
SP  - 42
TI  - Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/s41588-017-0014-7
UR  - https://www.nature.com/articles/s41588-017-0014-7
UR  - http://hdl.handle.net/10044/1/55618
VL  - 50
ER  -
Download