Imperial College London
Portrait Picture

ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
//

Contact

 

m.jarvelin

 
 
//

Location

 

302School of Public HealthWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Jiang:2018:10.1038/s41467-017-02662-2,
author = {Jiang, X and O'Reilly, PF and Aschard, H and Hsu, Y-H and Richards, JB and Dupuis, J and Ingelsson, E and Karasik, D and Pilz, S and Berry, D and Kestenbaum, B and Zheng, J and Luan, J and Sofianopoulou, E and Streeten, EA and Albanes, D and Lutsey, PL and Yao, L and Tang, W and Econs, MJ and Wallaschofski, H and Voelzke, H and Zhou, A and Power, C and McCarthy, MI and Michos, ED and Boerwinkle, E and Weinstein, SJ and Freedman, ND and Huang, W-Y and Van, Schoor NM and van, der Velde N and de, Groot LCPGM and Enneman, A and Cupples, LA and Booth, SL and Vasan, RS and Liu, C-T and Zhou, Y and Ripatti, S and Ohlsson, C and Vandenput, L and Lorentzon, M and Eriksson, JG and Shea, MK and Houston, DK and Kritchevsky, SB and Liu, Y and Lohman, KK and Ferrucci, L and Peacock, M and Gieger, C and Beekman, M and Slagboom, E and Deelen, J and van, Heemst D and Kleber, ME and Maerz, W and de, Boer IH and Wood, AC and Rotter, JI and Rich, SS and Robinson-Cohen, C and den, Heijer M and Jarvelin, M-},
doi = {10.1038/s41467-017-02662-2},
journal = {Nature Communications},
pages = {1--12},
title = {Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels},
url = {http://dx.doi.org/10.1038/s41467-017-02662-2},
volume = {9},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10−9 at rs8018720 in SEC23A, and P = 1.9×10−14 at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene–gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.
AU  - Jiang,X
AU  - O'Reilly,PF
AU  - Aschard,H
AU  - Hsu,Y-H
AU  - Richards,JB
AU  - Dupuis,J
AU  - Ingelsson,E
AU  - Karasik,D
AU  - Pilz,S
AU  - Berry,D
AU  - Kestenbaum,B
AU  - Zheng,J
AU  - Luan,J
AU  - Sofianopoulou,E
AU  - Streeten,EA
AU  - Albanes,D
AU  - Lutsey,PL
AU  - Yao,L
AU  - Tang,W
AU  - Econs,MJ
AU  - Wallaschofski,H
AU  - Voelzke,H
AU  - Zhou,A
AU  - Power,C
AU  - McCarthy,MI
AU  - Michos,ED
AU  - Boerwinkle,E
AU  - Weinstein,SJ
AU  - Freedman,ND
AU  - Huang,W-Y
AU  - Van,Schoor NM
AU  - van,der Velde N
AU  - de,Groot LCPGM
AU  - Enneman,A
AU  - Cupples,LA
AU  - Booth,SL
AU  - Vasan,RS
AU  - Liu,C-T
AU  - Zhou,Y
AU  - Ripatti,S
AU  - Ohlsson,C
AU  - Vandenput,L
AU  - Lorentzon,M
AU  - Eriksson,JG
AU  - Shea,MK
AU  - Houston,DK
AU  - Kritchevsky,SB
AU  - Liu,Y
AU  - Lohman,KK
AU  - Ferrucci,L
AU  - Peacock,M
AU  - Gieger,C
AU  - Beekman,M
AU  - Slagboom,E
AU  - Deelen,J
AU  - van,Heemst D
AU  - Kleber,ME
AU  - Maerz,W
AU  - de,Boer IH
AU  - Wood,AC
AU  - Rotter,JI
AU  - Rich,SS
AU  - Robinson-Cohen,C
AU  - den,Heijer M
AU  - Jarvelin,M-R
AU  - Cavadino,A
AU  - Joshi,PK
AU  - Wilson,JF
AU  - Hayward,C
AU  - Lind,L
AU  - Michaelsson,K
AU  - Trompet,S
AU  - Zillikens,MC
AU  - Uitterlinden,AG
AU  - Rivadeneira,F
AU  - Broer,L
AU  - Zgaga,L
AU  - Campbell,H
AU  - Theodoratou,E
AU  - Farrington,SM
AU  - Timofeeva,M
AU  - Dunlop,MG
AU  - Valdes,AM
AU  - Tikkanen,E
AU  - Lehtimaki,T
AU  - Lyytikainen,L-P
AU  - Kahonen,M
AU  - Raitakari,OT
AU  - Mikkila,V
AU  - Ikram,MA
AU  - Sattar,N
AU  - Jukema,JW
AU  - Wareham,NJ
AU  - Langenberg,C
AU  - Forouhi,NG
AU  - Gundersen,TE
AU  - Khaw,K-T
AU  - Butterworth,AS
AU  - Danesh,J
AU  - Spector,T
AU  - Wang,TJ
AU  - Hypponen,E
AU  - Kraft,P
AU  - Kiel,DP
DO  - 10.1038/s41467-017-02662-2
EP  - 12
PY  - 2018///
SN  - 2041-1723
SP  - 1
TI  - Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-017-02662-2
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000422650500011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41467-017-02662-2
UR  - http://hdl.handle.net/10044/1/85672
VL  - 9
ER  -
Download