102 results found
Ferner RE, Hughes RAC, Hall SM, et al., 2004, Neurofibromatous neuropathy in neurofibromatosis 1 (NF1), JOURNAL OF MEDICAL GENETICS, Vol: 41, Pages: 837-841, ISSN: 0022-2593
Taylor I, Marini C, Johnson MR, et al., 2004, Juvenile myoclonic epilepsy and idiopathic photosensitive occipital lobe epilepsy: is there overlap?, BRAIN, Vol: 127, Pages: 1878-1886, ISSN: 0006-8950
Johnson MR, Milne RL, Torn-Broers Y, et al., 2003, A twin study of genetic influences on epilepsy outcome, Twin Research, Pages: 1-7
Johnson MR, 2003, GABA receptors and refractory temporal lobe epilepsy (Commentary), Neurology
Kinton L, Johnson MR, Smith SJM, et al., 2002, Partial epilepsy with pericentral spikes: A new familial epilepsy syndrome with evidence for linkage to chromosome 4p15, ANNALS OF NEUROLOGY, Vol: 51, Pages: 740-749, ISSN: 0364-5134
Rees JH, Hain SF, Johnson MR, et al., 2001, The role of [18F]fluoro-2-deoxyglucose-PET scanning in the diagnosis of paraneoplastic neurological disorders., Brain, Vol: 124, Pages: 2223-2231, ISSN: 0006-8950
The detection of an occult tumour in a patient with a suspected paraneoplastic neurological disorder (PND) may be difficult because of the limitations of conventional imaging techniques. [(18)F]fluoro-2-deoxyglucose-PET (FDG-PET) can visualize a small tumour anywhere within the body. We retrospectively reviewed the case notes of 43 unselected patients with suspected PND referred for FDG-PET scanning to determine how useful this technique was when conventional imaging was negative. All patients had undergone standard radiological investigations and bronchoscopy (where appropriate) prior to PET scanning. There were discrete areas of hypermetabolism suggestive of malignancy (positive) in 16 patients (37%). A tissue diagnosis of cancer was subsequently made in seven patients (two at post-mortem), further radiological studies were suggestive of cancer in one patient, one patient subsequently presented with a metastatic deposit which was biopsied, and four patients died shortly afterwards without a post-mortem. In three patients, subsequent investigations were negative for cancer. Serum anti-neuronal antibodies were present in 43% and CSF oligoclonal bands were present in 46% of patients with positive PET scans compared with 16 and 26%, respectively, in PET-negative patients, but this was not significant. Only one patient with a negative scan has been diagnosed subsequently as having malignancy on prolonged follow-up. These findings confirm that FDG-PET scanning is a useful technique in the detection of small tumours in patients with suspected PND. False positives and false negatives do occur, but at a sufficiently low frequency to justify the clinical usefulness of this technique.
Johnson MR, Good CD, Penny WD, et al., 2001, Lesson of the week - Playing the odds in clinical decision making: lessons from berry aneurysms undetected by magnetic resonance angiography, BRITISH MEDICAL JOURNAL, Vol: 322, Pages: 1347-1349, ISSN: 0959-535X
Johnson MR, Goode CD, Penny W, et al., 2001, Playing the odds in clinical decision making: lessons from Berry aneurysms undetected by magnetic resonance angiography, British Medical Journal, Pages: 1347-1349
Johnson MR, Ferner R, Hughes RAC, et al., 2000, Detailed analysis of the oligodendrocyte myelin glycoprotein gene in four patients with neurofibromatosis 1 and primary progressive multiple sclerosis, J Neurol Neurosurg Psych, Pages: 643-646
Ferner RE, Hughes RA, Johnson MR, 1995, Neurofibromatosis 1 and multiple sclerosis., Journal of Neurology, Neurosurgery & Psychiatry, Vol: 58, Pages: 582-585, ISSN: 0022-3050
Clark AJL, Lavender PM, Coates P, et al., 1990, In Vitroandin VivoAnalysis of the Processing and Fate of the Peptide Products of the Short Proopiomelanocortin mRNA, Molecular Endocrinology, Vol: 4, Pages: 1737-1743, ISSN: 0888-8809
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