Imperial College London

ProfessorMichaelJohnson

Faculty of MedicineDepartment of Brain Sciences

Professor of Neurology and Genomic Medicine
 
 
 
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Contact

 

m.johnson Website

 
 
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Location

 

E419Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

102 results found

Ferner RE, Hughes RAC, Hall SM, Upadhyaya M, Johnson MRet al., 2004, Neurofibromatous neuropathy in neurofibromatosis 1 (NF1), JOURNAL OF MEDICAL GENETICS, Vol: 41, Pages: 837-841, ISSN: 0022-2593

Journal article

Taylor I, Marini C, Johnson MR, Turner S, Berkovic SF, Scheffer IEet al., 2004, Juvenile myoclonic epilepsy and idiopathic photosensitive occipital lobe epilepsy: is there overlap?, BRAIN, Vol: 127, Pages: 1878-1886, ISSN: 0006-8950

Journal article

Johnson MR, Milne RL, Torn-Broers Y, Hopper JL, Scheffer IE, Berkovic SFet al., 2003, A twin study of genetic influences on epilepsy outcome, Twin Research, Pages: 1-7

Journal article

Johnson MR, 2003, GABA receptors and refractory temporal lobe epilepsy (Commentary), Neurology

Journal article

Kinton L, Johnson MR, Smith SJM, Farrell F, Stevens J, Rance JB, Claudino AM, Duncan JS, Davis MB, Wood NW, Sander JWAet al., 2002, Partial epilepsy with pericentral spikes: A new familial epilepsy syndrome with evidence for linkage to chromosome 4p15, ANNALS OF NEUROLOGY, Vol: 51, Pages: 740-749, ISSN: 0364-5134

Journal article

Rees JH, Hain SF, Johnson MR, Hughes RA, Costa DC, Ell PJ, Keir G, Rudge Pet al., 2001, The role of [18F]fluoro-2-deoxyglucose-PET scanning in the diagnosis of paraneoplastic neurological disorders., Brain, Vol: 124, Pages: 2223-2231, ISSN: 0006-8950

The detection of an occult tumour in a patient with a suspected paraneoplastic neurological disorder (PND) may be difficult because of the limitations of conventional imaging techniques. [(18)F]fluoro-2-deoxyglucose-PET (FDG-PET) can visualize a small tumour anywhere within the body. We retrospectively reviewed the case notes of 43 unselected patients with suspected PND referred for FDG-PET scanning to determine how useful this technique was when conventional imaging was negative. All patients had undergone standard radiological investigations and bronchoscopy (where appropriate) prior to PET scanning. There were discrete areas of hypermetabolism suggestive of malignancy (positive) in 16 patients (37%). A tissue diagnosis of cancer was subsequently made in seven patients (two at post-mortem), further radiological studies were suggestive of cancer in one patient, one patient subsequently presented with a metastatic deposit which was biopsied, and four patients died shortly afterwards without a post-mortem. In three patients, subsequent investigations were negative for cancer. Serum anti-neuronal antibodies were present in 43% and CSF oligoclonal bands were present in 46% of patients with positive PET scans compared with 16 and 26%, respectively, in PET-negative patients, but this was not significant. Only one patient with a negative scan has been diagnosed subsequently as having malignancy on prolonged follow-up. These findings confirm that FDG-PET scanning is a useful technique in the detection of small tumours in patients with suspected PND. False positives and false negatives do occur, but at a sufficiently low frequency to justify the clinical usefulness of this technique.

Journal article

Johnson MR, Good CD, Penny WD, Barnes PRJ, Scadding JWet al., 2001, Lesson of the week - Playing the odds in clinical decision making: lessons from berry aneurysms undetected by magnetic resonance angiography, BRITISH MEDICAL JOURNAL, Vol: 322, Pages: 1347-1349, ISSN: 0959-535X

Journal article

Johnson MR, Johnson MR, Sander JWAS, Sander JWASet al., 2001, The clinical impact of epilepsy genetics, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 70, Pages: 428-430, ISSN: 0022-3050

Journal article

Johnson MR, Goode CD, Penny W, Barnes P, Scadding JWet al., 2001, Playing the odds in clinical decision making: lessons from Berry aneurysms undetected by magnetic resonance angiography, British Medical Journal, Pages: 1347-1349

Journal article

Johnson MR, Ferner R, Hughes RAC, Bobrow Met al., 2000, Detailed analysis of the oligodendrocyte myelin glycoprotein gene in four patients with neurofibromatosis 1 and primary progressive multiple sclerosis, J Neurol Neurosurg Psych, Pages: 643-646

Journal article

Ferner RE, Hughes RA, Johnson MR, 1995, Neurofibromatosis 1 and multiple sclerosis., Journal of Neurology, Neurosurgery & Psychiatry, Vol: 58, Pages: 582-585, ISSN: 0022-3050

Journal article

Clark AJL, Lavender PM, Coates P, Johnson MR, Rees LHet al., 1990, In Vitroandin VivoAnalysis of the Processing and Fate of the Peptide Products of the Short Proopiomelanocortin mRNA, Molecular Endocrinology, Vol: 4, Pages: 1737-1743, ISSN: 0888-8809

Journal article

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