Imperial College London

ProfessorMichaelJohnson

Faculty of MedicineDepartment of Brain Sciences

Professor of Neurology and Genomic Medicine
 
 
 
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Contact

 

m.johnson Website

 
 
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Location

 

E419Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Heavin:2019:10.1002/epi4.12360,
author = {Heavin, SB and McCormack, M and Wolking, S and Slattery, L and Walley, N and Avbersek, A and Novy, J and Sinha, SR and Radtke, R and Doherty, C and Auce, P and Craig, J and Johnson, MR and Koeleman, BPC and Krause, R and Kunz, WS and Marson, AG and O'Brien, TJ and Sander, JW and Sills, GJ and Stefansson, H and Striano, P and Zara, F and EPIGEN, Consortium and EpiPGX, Consortium and Depondt, C and Sisodiya, S and Goldstein, D and Lerche, H and Cavalleri, GL and Delanty, N},
doi = {10.1002/epi4.12360},
journal = {Epilepsia Open},
pages = {563--571},
title = {Genomic and clinical predictors of lacosamide response in refractory epilepsies},
url = {http://dx.doi.org/10.1002/epi4.12360},
volume = {4},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Objective: Clinical and genetic predictors of response to antiepileptic drugs (AEDs) are largely unknown. We examined predictors of lacosamide response in a real-world clinical setting. Methods: We tested the association of clinical predictors with treatment response using regression modeling in a cohort of people with refractory epilepsy. Genetic assessment for lacosamide response was conducted via genome-wide association studies and exome studies, comprising 281 candidate genes. Results: Most patients (479/483) were treated with LCM in addition to other AEDs. Our results corroborate previous findings that patients with refractory genetic generalized epilepsy (GGE) may respond to treatment with LCM. No clear clinical predictors were identified. We then compared 73 lacosamide responders, defined as those experiencing greater than 75% seizure reduction or seizure freedom, to 495 nonresponders (<25% seizure reduction). No variants reached the genome-wide significance threshold in our case-control analysis. Significance: No genetic predictor of lacosamide response was identified. Patients with refractory GGE might benefit from treatment with lacosamide.
AU - Heavin,SB
AU - McCormack,M
AU - Wolking,S
AU - Slattery,L
AU - Walley,N
AU - Avbersek,A
AU - Novy,J
AU - Sinha,SR
AU - Radtke,R
AU - Doherty,C
AU - Auce,P
AU - Craig,J
AU - Johnson,MR
AU - Koeleman,BPC
AU - Krause,R
AU - Kunz,WS
AU - Marson,AG
AU - O'Brien,TJ
AU - Sander,JW
AU - Sills,GJ
AU - Stefansson,H
AU - Striano,P
AU - Zara,F
AU - EPIGEN,Consortium
AU - EpiPGX,Consortium
AU - Depondt,C
AU - Sisodiya,S
AU - Goldstein,D
AU - Lerche,H
AU - Cavalleri,GL
AU - Delanty,N
DO - 10.1002/epi4.12360
EP - 571
PY - 2019///
SN - 2470-9239
SP - 563
TI - Genomic and clinical predictors of lacosamide response in refractory epilepsies
T2 - Epilepsia Open
UR - http://dx.doi.org/10.1002/epi4.12360
UR - https://www.ncbi.nlm.nih.gov/pubmed/31819912
UR - http://hdl.handle.net/10044/1/76021
VL - 4
ER -