Imperial College London

ProfessorMichaelJohnson

Faculty of MedicineDepartment of Brain Sciences

Professor of Neurology and Genomic Medicine
 
 
 
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Contact

 

m.johnson Website

 
 
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Location

 

E419Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Johnson:2019:10.1016/j.neuropharm.2019.107868,
author = {Johnson, MR and Kaminski, RM},
doi = {10.1016/j.neuropharm.2019.107868},
journal = {Neuropharmacology},
pages = {1--15},
title = {A systems-level framework for anti-epilepsy drug discovery},
url = {http://dx.doi.org/10.1016/j.neuropharm.2019.107868},
volume = {170},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Modern anti-seizure drug development yielded benefits in terms of improved pharmacokinetics, safety and tolerability profiles, but offered no advances in efficacy compared to previous older generations of anti-seizure drugs. Despite significant advances in our understanding of the genetic bases to epilepsy, and a welcome renewed interest on the severe monogenic epilepsies, modern genetics has yet to directly inform more effective or disease-modifying anti-seizure drugs. Here, we describe a new approach to the identification of novel disease modifying anti-epilepsy drugs. The systems genetics approach aims to first identify pathophysiological mechanisms by integrating polygenic risk with cellular gene expression profiles and then to relate these molecular mechanisms to druggable targets using a gene regulatory (regulome) framework. The approach offers an exciting and flexible framework for future drug discovery in epilepsy, and is applicable to any disease for which appropriate cell-type and disease-context specific data exist.
AU - Johnson,MR
AU - Kaminski,RM
DO - 10.1016/j.neuropharm.2019.107868
EP - 15
PY - 2019///
SN - 0028-3908
SP - 1
TI - A systems-level framework for anti-epilepsy drug discovery
T2 - Neuropharmacology
UR - http://dx.doi.org/10.1016/j.neuropharm.2019.107868
UR - https://www.ncbi.nlm.nih.gov/pubmed/31785261
UR - https://www.sciencedirect.com/science/article/pii/S0028390819304344?via%3Dihub
UR - http://hdl.handle.net/10044/1/75471
VL - 170
ER -