Imperial College London
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ProfessorMichaelJohnson

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology and Genomic Medicine
 
 
 
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Contact

 

m.johnson Website

 
 
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Location

 

E419Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Scott:2016:10.1016/j.seizure.2016.10.023,
author = {Scott, G and Mahmud, M and Owen, DR and Johnson, MR},
doi = {10.1016/j.seizure.2016.10.023},
journal = {Seizure-European Journal of Epilepsy},
pages = {42--47},
title = {Microglial positron emission tomography (PET) imaging in epilepsy: applications, opportunities and pitfalls},
url = {http://dx.doi.org/10.1016/j.seizure.2016.10.023},
volume = {44},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Neuroinflammation is increasingly implicated in epileptogenesis and epilepsy. Microglia are an important mediator of central nervous system inflammation, and the development of positron emission tomography (PET) radioligands which bind the Translocator Protein (TSPO), an outer mitochondrial membrane protein expressed by microglia, has enabled in vivo measurement of neuroinflammation. Here, we outline the principles and potential pitfalls of TSPO PET imaging in relation to epilepsy, and opportunities for using TSPO imaging as a biomarker for future anti-inflammatory based therapeutics in epilepsy.
AU  - Scott,G
AU  - Mahmud,M
AU  - Owen,DR
AU  - Johnson,MR
DO  - 10.1016/j.seizure.2016.10.023
EP  - 47
PY  - 2016///
SN  - 1059-1311
SP  - 42
TI  - Microglial positron emission tomography (PET) imaging in epilepsy: applications, opportunities and pitfalls
T2  - Seizure-European Journal of Epilepsy
UR  - http://dx.doi.org/10.1016/j.seizure.2016.10.023
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27884611
UR  - http://hdl.handle.net/10044/1/43103
VL  - 44
ER  -
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