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@article{Herberg:2013:infdis/jit348,
author = {Herberg, JA and Kaforou, M and Gormley, S and Sumner, ER and Patel, S and Jones, KDJ and Paulus, S and Fink, C and Martinon-Torres, F and Montana, G and Wright, VJ and Levin, M},
doi = {infdis/jit348},
journal = {Journal of Infectious Diseases},
pages = {1664--1668},
title = {Transcriptomic Profiling in Childhood H1N1/09 Influenza Reveals Reduced Expression of Protein Synthesis Genes},
url = {http://dx.doi.org/10.1093/infdis/jit348},
volume = {208},
year = {2013}
}

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TY  - JOUR
AB  - We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterized the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalized with H1N1/09 infection.
AU  - Herberg,JA
AU  - Kaforou,M
AU  - Gormley,S
AU  - Sumner,ER
AU  - Patel,S
AU  - Jones,KDJ
AU  - Paulus,S
AU  - Fink,C
AU  - Martinon-Torres,F
AU  - Montana,G
AU  - Wright,VJ
AU  - Levin,M
DO  - infdis/jit348
EP  - 1668
PY  - 2013///
SN  - 1537-6613
SP  - 1664
TI  - Transcriptomic Profiling in Childhood H1N1/09 Influenza Reveals Reduced Expression of Protein Synthesis Genes
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jit348
UR  - http://hdl.handle.net/10044/1/29042
VL  - 208
ER  -

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myrsini kaforou

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