Imperial College London
Alternate

myrsini kaforou

Faculty of Medicine, Department of Infectious Disease

Senior Lecturer in Bioinformatics
 
 
 
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Contact

 

+44 (0)20 7594 3915m.kaforou

 
 
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Location

 

231Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gliddon:2017:10.1111/imm.12841,
author = {Gliddon, HD and Herberg, JA and Levin, M and Kaforou, M},
doi = {10.1111/imm.12841},
journal = {Immunology},
pages = {171--178},
title = {Genome-wide host RNA signatures of infectious diseases: discovery and clinical translation.},
url = {http://dx.doi.org/10.1111/imm.12841},
volume = {153},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The use of whole blood gene expression to derive diagnostic biomarkers capable of distinguishing between phenotypically similar diseases holds great promise but remains a challenge. Differential gene expression analysis is used to identify the key genes that undergo changes in expression relative to healthy individuals, as well as to patients with other diseases. These key genes can act as diagnostic, prognostic and predictive markers of disease. Gene expression 'signatures' in the blood hold potential to be used for the diagnosis of infectious diseases, where current diagnostics are unreliable, ineffective or of limited potential. For diagnostic tests based on RNA signatures to be useful clinically, the first step is to identify the minimum set of gene transcripts that accurately identify the disease in question. The second requirement is rapid and cost effective detection of the gene expression levels. Whilst signatures have been described for a number of infectious diseases, 'clinic-ready' technologies for RNA detection from clinical samples are limited, though existing methods such as reverse transcription-polymerase chain reaction (RT-PCR) are likely to be superseded by a number of emerging technologies, which may form the basis of the translation of gene expression signatures into routine diagnostic tests for a range of disease states.
AU  - Gliddon,HD
AU  - Herberg,JA
AU  - Levin,M
AU  - Kaforou,M
DO  - 10.1111/imm.12841
EP  - 178
PY  - 2017///
SN  - 0019-2805
SP  - 171
TI  - Genome-wide host RNA signatures of infectious diseases: discovery and clinical translation.
T2  - Immunology
UR  - http://dx.doi.org/10.1111/imm.12841
UR  - http://hdl.handle.net/10044/1/53291
VL  - 153
ER  -
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