Imperial College London

Dr Kuimova

Faculty of Natural SciencesDepartment of Chemistry

Reader in Chemical Physics
 
 
 
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Contact

 

+44 (0)20 7594 8558m.kuimova

 
 
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Location

 

134bChemistrySouth Kensington Campus

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Summary

 

Summary

Dr Marina Kuimova received a M.Sc. in Chemistry from Moscow State University in 2001, and a Ph.D from Nottingham University in 2005.   She is currently a Reader (Associate Professor) in the Department of Chemistry.

Research

My research interests include elucidation of biologically relevant processes using different types of fluorescence imaging and time-resolved spectroscopy. The detailed description of my research activities can be found here

The popular article and the video clip where I talk to the media can be found here.

For a bit of fun, read the NatureChem 'The Sceptical Chymist' blog entry here

Opportunities

We are always looking to recruit talented and dedicated scientists. If you are interested in joining the group, please get in touch! It is likely that the funding for one or more PhD projects will be available for the 2017/2018 start date.

Prospective PhD students please make note of the President's PhD Scholarship Scheme

Funded positions will be advertised here when available:

NEW!! A PDRA position in PLIM probes:

Applications are invited for a postdoctoral position in my group, in collaboration with Prof Ramon Vilar and Dr Jean-Baptise Vannier, working on the development  of phosphorescence lifetime imaging (PLIM) probes for DNA G-quadruplexes. Please check the jobs.ac.uk advert here

Two PDRA positions are available:

Applications are invited for two postdoctoral positions in my group, in collaboration with Prof Ramon Vilar and Dr Jean-Baptise Vannier, working on the development  of novel probes for DNA G-quadruplexes. Please check the jobs.ac.uk adverts for the research associate positions in the Synthesis of Optical Probes and in Optical Spectroscopy and Imaging 

One DTC PhD studentship is available:

Applications are invited for an Medical Imaging CDT fully funded MRes+PhD studentship for a 2017/18 start. Please check our studentship Novel probes to correlate microscopic and macroscopic tumour structures (collaboration with Dr Gilbert Fruhwirth).

NEWS

*March 2017: 
Our bid for Imperial Excellence Fund for Frontier Research in collaboration with Prof Ramon Vilar and Dr Jean-Baptiste Vannier was successful! Read about 'Searching for DNA quadruplexes' here.

*February 2017: 
Thanos Athanasiadis has successfully defended his PhD Thesis. Congratulations to Thanos!

*November 2016: 
Mike Dent has successfully defended his PhD Thesis. Congratulations to Mike!

*October 2016: 
Aurimas has successfully defended his PhD Thesis. He has also started an EPSRC Doctoral Prize Fellowship in the group on the 1st October. Congratulations to Aurimas!

*July 2016:
Marketa Kubankova won the best talk prize in the Imaging, Sensing and Analytical Chemistry Section' of the final year postgraduate symposium at Imperial. Congratulations to Marketa!

*March 2016:
Our new paper entitled 'Direct imaging of changes in aerosol particle viscosity upon hydration and chemical aging' has appeared in Chemical Science. Here we report imaging of microscopic viscosity in model atmospheric aerosols.

A recent developement on this technioque, enabling optical levitation of aerosol particles under investigation, has been published in PCCP1 and PCCP2. 

*August-July 2015:
Our new paper entitled 'Unravelling the effect of temperature on viscosity-sensitive fluorescent molecular rotors' has appeared in Chemical Science. Here we report simultaneous imaging of viscosity and temperature using a single fluorophore.

Also please read about a red-emitting BODIPY-based temperature sensor, working via FLIM, here

*July 2015:
Our new paper entitled 'Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors' has appeared in PCCP. Check it out for comparison between molecular rotors, FCS and MD simulations to calculate the viscosity of membranes. Congratulations to Mike and Ismael!

*June 2015:
Aurimas Vysniauskas won the best talk prize in the 'Physical and Analytical Section' of the final year postgraduate symposium at Imperial. Congratulations to Aurimas!

 

Recent publications 

N. A. Hosny et al Direct imaging of changes in aerosol particle viscosity upon hydration and chemical aging, Chem. Sci., 2016, 7, 1357-1367

T.T. Vu et al Tuning BODIPY molecular rotors into the red: sensitivity to viscosity vs temperature, J. Mater. Chem. C, 2016, 4, 2828 - 2833

A. Shivalingam, et al The interactions between a small molecule and G-quadruplexes are visualised by fluorescence lifetime imaging microscopy. Nature Commun., 2015, 6, 8178

A. Vysniauskas et al Unravelling the effect of temperature on viscosity-sensitive fluorescent molecular rotors, Chem Sci., 2015, DOI: 10.1039/C5SC02248G

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I. Lopez-Duarte, T. T. Vu, et al A molecular rotor for measuring viscosity in plasma membranes of live cells, Chem. Commun., 2014, DOI: 10.1039/C3CC47530A (Emerging investigators issue)

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Neveen A. Hosny et al Mapping microbubble viscosity using fluorescence lifetime imaging of molecular rotors, PNAS, 2013

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M.K. Kuimova Mapping viscosity in cells using molecular rotors, PCCP, 2012, 14, 12671-12686

 PCCP

M. K. Kuimova, S. W. Botchway, A. W. Parker, M. Balaz, H. A. Collins, H. L. Anderson, K. Suhling, P. R. Ogilby, Imaging Intracellular Viscosity of a Single Cell During Photoinduced Cell Death, Nature Chem., 2009, 1, 69 

cell death

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Publications

Journals

Carugo D, Aron M, Sezgin E, et al., 2017, Modulation of the molecular arrangement in artificial and biological membranes by phospholipid-shelled microbubbles., Biomaterials, Vol:113, Pages:105-117

Davidson N, Tong H-J, Kalberer M, et al., 2017, Measurement of the Raman spectra and hygroscopicity of four pharmaceutical aerosols as they travel from pressurised metered dose inhalers (pMDI) to a model lung, International Journal of Pharmaceutics, Vol:520, ISSN:0378-5173, Pages:59-69

Kubánková M, López-Duarte I, Bull JA, et al., 2017, Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors., Biomaterials, Vol:139, Pages:195-201

Sherin PS, Lopez-Duarte I, Dent MR, et al., 2017, Visualising the membrane viscosity of porcine eye lens cells using molecular rotors, Chemical Science, Vol:8, ISSN:2041-6520, Pages:3523-3528

Shimolina LE, Izquierdo MA, Lopez-Duarte I, et al., 2017, Imaging tumor microscopic viscosity in vivo using molecular rotors, Scientific Reports, Vol:7, ISSN:2045-2322

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