Dr Maria Kyrgiou is a Clinical Reader (Associate Professor) at Imperial College London and a Consultant Surgeon in Gynaecology and Gynaecologic Oncology at the West London Gynaecological Cancer Centre, Imperial Healthcare NHS Trust.
The primary focus of her research is traslational research in gynaecological diseases and cancers, in particular cervical, endometrial and ovarian cancer with an emphasis on prevention and personalised treatment.
She has an interest in cervical pre-invasive and invasive disease, primary cervical screening and HPV vaccines. She has led research into the impact of treatment for cervical pre-invasive and early invasive cervical disease on reproductive outcomes and the clinical use of HPV biomarkers in personalising the management of women with abnormal findings at primary population-based screening.
She runs a research group investigating the impact of obesity and metabolic disorders in the development of gynaecological cancers with an emphasis on endometrial cancer.
She further investigates the role of the genital tract and gut microbiome and host interactions in the development and treatment response of gynaecological cancers.
et al., 2017, Adiposity and cancer at major anatomical sites: umbrella review of the literature, British Medical Journal, Vol:356, ISSN:1756-1833
et al., 2015, Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity, Scientific Reports, Vol:5, ISSN:2045-2322
et al., 2006, Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis, The Lancet, Vol:367, ISSN:0140-6736, Pages:489-498
et al., 2008, Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis, British Medical Journal, Vol:337, ISSN:0959-535X
et al., 2014, Histology Verification Demonstrates That Biospectroscopy Analysis of Cervical Cytology Identifies Underlying Disease More Accurately than Conventional Screening: Removing the Confounder of Discordance, PLOS One, Vol:9, ISSN:1932-6203
et al., 2012, Centralisation of services for gynaecological cancer, Cochrane Database of Systematic Reviews, ISSN:1469-493X
et al., 2006, Survival benefits with diverse chemotherapy regimens for ovarian cancer: Meta-analysis of multiple treatments, Journal of the National Cancer Institute, Vol:98, ISSN:0027-8874, Pages:1655-1663
et al., 2014, Management of stage Ia1 squamous cervical cancer and the importance of excision margins: a retrospective study of long-term outcome after 25 years of follow-up, American Journal of Obstetrics and Gynecology, Vol:211, ISSN:0002-9378
et al., 2014, Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: systematic review and meta-analysis, British Medical Journal, Vol:349, ISSN:1756-1833
et al., 2015, Extracting biomarkers of commitment to cancer development: potential role of vibrational spectroscopy in systems biology, Expert Review of Molecular Diagnostics, Vol:15, ISSN:1473-7159, Pages:693-713