Imperial College London

Dr Maria Kyrgiou

Faculty of MedicineDepartment of Surgery & Cancer

Clinical Senior Lecturer in Gynaecological Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.kyrgiou Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

128 results found

Domenici L, Nixon K, Sorbi F, Kyrgiou M, Yazbek J, Hall M, Campbell J, Gibbons N, Park W-HE, Gabra H, Fotopoulou Cet al., 2017, Surgery for Recurrent Uterine Cancer: Surgical Outcomes and Implications for SurvivalA Case Series, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 27, Pages: 759-767, ISSN: 1048-891X

JOURNAL ARTICLE

Halliwell DE, Morais CLM, Lima KMG, Trevisan J, Siggel-King MRF, Craig T, Ingham J, Martin DS, Heys K, Kyrgiou M, Mitra A, Paraskevaidis E, Theophilou G, Martin-Hirsch PL, Cricenti A, Luce M, Weightman P, Martin FLet al., 2017, An imaging dataset of cervical cells using scanning near-field optical microscopy coupled to an infrared free electron laser, SCIENTIFIC DATA, Vol: 4, ISSN: 2052-4463

JOURNAL ARTICLE

Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Mitra A, Terzidou V, Bennett P, Martin-Hirsch P, Tsilidis KK, Kyrgiou Met al., 2017, Obesity and gynaecological and obstetric conditions: umbrella review of the literature., BMJ, Vol: 359

Objective To study the strength and validity of associations between adiposity and risk of any type of obstetric or gynaecological conditions.Design An umbrella review of meta-analyses.Data sources PubMed, Cochrane database of systematic reviews, manual screening of references for systematic reviews or meta-analyses of observational and interventional studies evaluating the association between adiposity and risk of any obstetrical or gynaecological outcome.Main outcomes Meta-analyses of cohort studies on associations between indices of adiposity and obstetric and gynaecological outcomes.Data synthesis Evidence from observational studies was graded into strong, highly suggestive, suggestive, or weak based on the significance of the random effects summary estimate and the largest study in the included meta-analysis, the number of cases, heterogeneity between studies, 95% prediction intervals, small study effects, excess significance bias, and sensitivity analysis with credibility ceilings. Interventional meta-analyses were assessed separately.Results 156 meta-analyses of observational studies were included, investigating associations between adiposity and risk of 84 obstetric or gynaecological outcomes. Of the 144 meta-analyses that included cohort studies, only 11 (8%) had strong evidence for eight outcomes: adiposity was associated with a higher risk of endometrial cancer, ovarian cancer, antenatal depression, total and emergency caesarean section, pre-eclampsia, fetal macrosomia, and low Apgar score. The summary effect estimates ranged from 1.21 (95% confidence interval 1.13 to 1.29) for an association between a 0.1 unit increase in waist to hip ratio and risk endometrial cancer up to 4.14 (3.61 to 4.75) for risk of pre-eclampsia for BMI >35 compared with <25. Only three out of these eight outcomes were also assessed in meta-analyses of trials evaluating weight loss interventions. These interventions significantly reduced the ris

JOURNAL ARTICLE

Kottaridi C, Kyrgiou M, Pouliakis A, Magkana M, Aga E, Spathis A, Mitra A, Makris G, Chrelias C, Mpakou V, Paraskevaidis E, Panayiotides JG, Karakitsos Pet al., 2017, Quantitative Measurement of L1 Human Papillomavirus Type 16 Methylation for the Prediction of Preinvasive and Invasive Cervical Disease, JOURNAL OF INFECTIOUS DISEASES, Vol: 215, Pages: 764-771, ISSN: 0022-1899

JOURNAL ARTICLE

Kyrgiou M, Bennett P, 2017, Can we prevent preterm birth after radical trachelectomy?, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 124, Pages: 1737-1737, ISSN: 1470-0328

JOURNAL ARTICLE

Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KKet al., 2017, Adiposity and cancer at major anatomical sites: umbrella review of the literature, BMJ-BRITISH MEDICAL JOURNAL, Vol: 356, ISSN: 1756-1833

JOURNAL ARTICLE

Kyrgiou M, Kalliala I, Mitra A, Ng KYB, Raglan O, Fotopoulou C, Martin-Hirsch P, Paraskevaidis E, Arbyn Met al., 2017, Immediate referral to colposcopy versus cytological surveillance for low-grade cervical cytological abnormalities in the absence of HPV test: A systematic review and a meta-analysis of the literature, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 216-223, ISSN: 0020-7136

JOURNAL ARTICLE

Kyrgiou M, Kalliala IEJ, Mitra A, Fotopoulou C, Ghaem-Maghami S, Martin-Hirsch PPL, Cruickshank M, Arbyn M, Paraskevaidis Eet al., 2017, Immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of HPV test, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

JOURNAL ARTICLE

Kyrgiou M, Mitra A, Moscicki A-B, 2017, Does the vaginal microbiota play a role in the development of cervical cancer?, TRANSLATIONAL RESEARCH, Vol: 179, Pages: 168-182, ISSN: 1931-5244

JOURNAL ARTICLE

Mitra A, MacIntyre D, Lai J, Lee Y, Smith A, Marchesi J, Lyons D, Bennett P, Kyrgiou Met al., 2017, The Impact of Excisional Treatment for Cervical Intraepithelial Neoplasia on the Vaginal Microbiota., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 89A-89A, ISSN: 1933-7191

CONFERENCE PAPER

Mitra A, MacIntyre DA, Mahajan V, Lee YS, Smith A, Marchesi JR, Lyons D, Bennett PR, Kyrgiou Met al., 2017, Comparison of vaginal microbiota sampling techniques: cytobrush versus swab, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Nasser S, Kyrgiou M, Krell J, Haidopoulos D, Bristow R, Fotopoulou Cet al., 2017, A Review of Thoracic and Mediastinal Cytoreductive Techniques in Advanced Ovarian Cancer: Extending the Boundaries., Ann Surg Oncol

The aim of this study was to review the surgical and clinical outcomes of intrathoracic and mediastinal surgical cytoreduction in stage IV epithelial ovarian cancer (EOC). Relevant articles were identified from MEDLINE and EMBASE. Only analyses or reports that described actual intrathoracic cytoreduction via pleurectomy and/or resection of cardiophrenic/mediastinal lymph nodes were included. Imaging articles that merely described thoracic tumor patterns were excluded. A total of nine studies were identified, the oldest originating in 2007. Procedures described were transdiaphragmatic resection of cardiophrenic lymph nodes and pleural disease (n = 5) and video-assisted thoracoscopic and mediastinal tumorectomies including pleurectomy (n = 4). The number of operated patients ranged between 1 and 30 with complete cytoreduction rates ranging between 68 and 100%. No surgical deaths directly related to the thoracic cytoreduction were reported and only one patient (1/30) experienced a postoperative complication in terms of a pneumothorax. None of the studies presented a direct comparison of survival to patients with thoracic disease who did not undergo thoracic cytoreduction, and therefore the survival benefit of thoracic cytoreduction could not be quantified. In conclusion, thoracic cytoreduction in advanced EOC seems feasible and with acceptable morbidity while offering a better understanding of the extent of disease and hence allowing the tailoring of intraabdominal resections. Nevertheless, its direct impact on patients' survival by a potential overruling of a more adverse tumor biology remains to be established in larger-scale prospective and ideally randomized trials.

JOURNAL ARTICLE

Paraskevaidi M, Martin-Hirsch PL, Kyrgiou M, Martin FLet al., 2017, Underlying role of mitochondrial mutagenesis in the pathogenesis of a disease and current approaches for translational research, MUTAGENESIS, Vol: 32, Pages: 335-342, ISSN: 0267-8357

JOURNAL ARTICLE

Paraskevaidi M, Morais CLM, Raglan O, Lima KMG, Martin-Hirsch PL, Paraskevaidis E, Kyrgiou M, Martin FLet al., 2017, Spectroscopy of blood samples for the diagnosis of endometrial cancer and classification of its different subtypes., Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X

CONFERENCE PAPER

Farthing A, Kyrgiou M, 2016, Re: Laparoscopic radical abdominal trachelectomy for the management of stage IB1 cervical cancer at 14 weeks gestation: case report and review of the literature Reply, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 646-646, ISSN: 1470-0328

JOURNAL ARTICLE

Fotopoulou C, Jones BP, Savvatis K, Campbell J, Kyrgiou M, Farthing A, Brett S, Roux R, Hall M, Rustin G, Gabra H, Jiao L, Stumpfle Ret al., 2016, Maximal effort cytoreductive surgery for disseminated ovarian cancer in a UK setting: challenges and possibilities, ARCHIVES OF GYNECOLOGY AND OBSTETRICS, Vol: 294, Pages: 607-614, ISSN: 0932-0067

JOURNAL ARTICLE

Halliwell DE, Kyrgiou M, Mitra A, Kalliala I, Paraskevaidis E, Theophilou G, Martin-Hirsch PL, Martin FLet al., 2016, Tracking the Impact of Excisional Cervical Treatment on the Cervix using Biospectroscopy, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

Halliwell DE, Morais CLM, Lima KMG, Trevisan J, Siggel-King MRF, Craig T, Ingham J, Martin DS, Heys KA, Kyrgiou M, Mitra A, Paraskevaidis E, Theophilou G, Martin-Hirsch PL, Cricenti A, Luce M, Weightman P, Martin FLet al., 2016, Imaging cervical cytology with scanning near-field optical microscopy (SNOM) coupled with an IR-FEL, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

Kalliala I, Tsilidis K, Kyrgiou M, 2016, Obesity and Gynaecological Cancer - An Umbrella Review and Meta-Analysis., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 179A-179A, ISSN: 1933-7191

CONFERENCE PAPER

Kindinger LM, Kyrgiou M, MacIntyre DA, Cacciatore S, Yulia A, Cook J, Terzidou V, Teoh TG, Bennett PRet al., 2016, Preterm Birth Prevention Post-Conization: A Model of Cervical Length Screening with Targeted Cerclage, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Kyrgiou M, Athanasiou A, Paraskevadi M, Arbyn M, Mitra A, Martin-Hirsch P, Bennett P, Paraskevaidis Eet al., 2016, Risk of Preterm Birth After Treatment for Cervical Precancer Increases with Increasing Cone Depth: Systematic Review and Meta-Analysis., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 189A-190A, ISSN: 1933-7191

CONFERENCE PAPER

Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis Eet al., 2016, Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis, BMJ-BRITISH MEDICAL JOURNAL, Vol: 354, ISSN: 1756-1833

JOURNAL ARTICLE

Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis Eet al., 2016, Adverse Obstetric Outcomes After Local Treatment for Cervical Preinvasive and Early Invasive Disease According to Cone Depth: Systematic Review and Meta-analysis EDITORIAL COMMENT, OBSTETRICAL & GYNECOLOGICAL SURVEY, Vol: 71, Pages: 646-648, ISSN: 0029-7828

JOURNAL ARTICLE

Kyrgiou M, Mitra A, Athanasiou A, Paraskevaidi M, Arbyn M, Martin-Hirsch P, Bennett P, Paraskevaidis Eet al., 2016, The risk of preterm birth after treatment for cervical pre-invasive and early invasive disease increases with increasing cone depth: a systematic review and meta-analysis, Publisher: WILEY-BLACKWELL, Pages: E8-E8, ISSN: 1470-0328

CONFERENCE PAPER

Kyrgiou M, Mitra A, Paraskevaidis E, 2016, Fertility and Early Pregnancy Outcomes Following Conservative Treatment for Cervical Intraepithelial Neoplasia and Early Cervical Cancer, JAMA ONCOLOGY, Vol: 2, Pages: 1496-1498, ISSN: 2374-2437

JOURNAL ARTICLE

Kyrgiou M, Pouliakis A, Panayiotides JG, Margari N, Bountris P, Valasoulis G, Paraskevaidi M, Bilirakis E, Nasioutziki M, Loufopoulos A, Haritou M, Koutsouris DD, Karakitsos P, Paraskevaidis Eet al., 2016, Personalised management of women with cervical abnormalities using a clinical decision support scoring system, GYNECOLOGIC ONCOLOGY, Vol: 141, Pages: 29-35, ISSN: 0090-8258

JOURNAL ARTICLE

Mitra A, Kindinger L, Kalliala I, Smith JR, Paraskevaidis E, Bennett PR, Kyrgiou Met al., 2016, Obstetric complications after treatment of cervical intraepithelial neoplasia, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 77, Pages: C124-C127, ISSN: 1750-8460

JOURNAL ARTICLE

Mitra A, MacIntyre D, Lee Y, Smith A, Marchesi J, Lehne B, Bhatia R, Lyons D, Paraskevaidis E, Holmes E, Nicholson J, Bennett P, Kyrgiou Met al., 2016, Cervical Intraepithelial Neoplasia Disease Progression Is Associated with Increased Vaginal Microbiome Diversity., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 66A-66A, ISSN: 1933-7191

CONFERENCE PAPER

Mitra A, MacIntyre D, Lee Y, Smith A, Marchesi J, Lehne B, Bhatia R, Lyons D, Paraskevaidis E, Holmes E, Nicholson J, Bennett P, Kyrgiou Met al., 2016, Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity, Publisher: WILEY-BLACKWELL, Pages: E11-E12, ISSN: 1470-0328

CONFERENCE PAPER

Mitra A, MacIntyre DA, Marchesi JR, Lee YS, Bennett PR, Kyrgiou Met al., 2016, The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?, MICROBIOME, Vol: 4, ISSN: 2049-2618

JOURNAL ARTICLE

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