Imperial College London

Dr Maria Kyrgiou

Faculty of MedicineDepartment of Surgery & Cancer

Reader in Gynaecological Oncology
 
 
 
//

Contact

 

+44 (0)20 7594 2177m.kyrgiou Website

 
 
//

Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

//

Summary

 

Publications

Publication Type
Year
to

148 results found

Joura EA, Kyrgiou M, Bosch FX, Kesic V, Niemenen P, Redman CW, Gultekin Met al., 2019, Human papillomavirus vaccination: The ESGO–EFC position paper of the European society of Gynaecologic Oncology and the European Federation for colposcopy, European Journal of Cancer, Vol: 116, Pages: 21-26, ISSN: 0959-8049

© 2019 The Authors Vaccines against human papillomavirus (HPV) are available in Europe since 2006. They have been highly effective in preventing infection and disease caused by the vaccine types. Clinical efficacy data are available for cervical, vulvovaginal and anal precancer and invasive cervical cancer. Disease reduction is best with early vaccination and a coverage of more than 70%. Gender-neutral vaccination provides direct protection for all men and improves the coverage. A good coverage is followed by herd protection of the unvaccinated men and women. School-based programs appear to be most effective; under the age of 15 years, two doses with an interval of 6–12 months are sufficient. From the age of 15 years, the standard regimen with three doses is recommended. A broad catch-up program for young adult women and men improves the effectiveness. The vaccines are also effective in sexually active women and men with previous but cleared infections. Vaccination in addition to local treatment of HPV-related disease appears to reduce recurrent or subsequent HPV-related disease. Combination of HPV vaccination and screening with HPV testing is the most effective approach to prevention of cervical cancer. The screening intervals may increase in the vaccinated cohorts. The upper age limit for vaccination remains to be evaluated, is country specific and depends on cost-effectiveness. The European Society of Gynaecologic Oncology and the European Federation for Colposcopy strongly support gender-neutral vaccination programs for children and young adolescents, with a catch-up program for young adults.

JOURNAL ARTICLE

Wiik J, Sengpiel V, Kyrgiou M, Nilsson S, Mitra A, Tanbo T, Jonassen CM, Tannaes TM, Sjoborg Ket al., 2019, Cervical microbiota in women with cervical intra-epithelial neoplasia, prior to and after local excisional treatment, a Norwegian cohort study, BMC WOMENS HEALTH, Vol: 19, ISSN: 1472-6874

JOURNAL ARTICLE

Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou Met al., 2018, Risk factors for endometrial cancer: An umbrella review of the literature., Int J Cancer

Although many risk factors could have causal association with endometrial cancer, they are also prone to residual confounding or other biases which could lead to over- or underestimation. This umbrella review evaluates the strength and validity of evidence pertaining risk factors for endometrial cancer. Systematic reviews or meta-analyses of observational studies evaluating the association between non-genetic risk factors and risk of developing or dying from endometrial cancer were identified from inception to April 2018 using PubMed, the Cochrane database and manual reference screening. Evidence was graded strong, highly suggestive, suggestive or weak based on statistical significance of random-effects summary estimate, largest study included, number of cases, between-study heterogeneity, 95% prediction intervals, small study effects, excess significance bias and sensitivity analysis with credibility ceilings. We identified 171 meta-analyses investigating associations between 53 risk factors and endometrial cancer incidence and mortality. Risk factors were categorised: anthropometric indices, dietary intake, physical activity, medical conditions, hormonal therapy use, biochemical markers, gynaecological history and smoking. Of 127 meta-analyses including cohort studies, three associations were graded with strong evidence. Body mass index and waist-to-hip ratio were associated with increased cancer risk in premenopausal women (RR per 5 kg/m2 1.49; CI 1.39-1.61) and for total endometrial cancer (RR per 0.1unit 1.21; CI 1.13-1.29), respectively. Parity reduced risk of disease (RR 0.66, CI 0.60-0.74). Of many proposed risk factors, only three had strong association without hints of bias. Identification of genuine risk factors associated with endometrial cancer may assist in developing targeted prevention strategies for women at high risk.

JOURNAL ARTICLE

Dilley J, Pratt P, Kyrgiou M, Flott K, Darzi A, Mayer Eet al., 2018, Current and Future Use of Radiological Images in the Management of Gynecological Malignancies - A Survey of Practice in the UK, ANTICANCER RESEARCH, Vol: 38, Pages: 5867-5876, ISSN: 0250-7005

JOURNAL ARTICLE

Lathouras K, Saso S, Tzafetas M, Kalinderi K, Fidani S, Zournatzi V, Kyrgiou M, Fotopoulou C, Ghaem-Maghami S, Tzafetas Iet al., 2018, Genetic polymorphisms of matrix metalloproteinases 1-3 and their inhibitor are not associated with premature labor, FUTURE SCIENCE OA, Vol: 4, ISSN: 2056-5623

JOURNAL ARTICLE

Dardiotis E, Siokas V, Garas A, Paraskevaidis E, Kyrgiou M, Xiromerisiou G, Deligeoroglou E, Galazios G, Kontomanolis EN, Spandidos DA, Tsatsakis A, Daponte Aet al., 2018, Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions, ONCOLOGY LETTERS, Vol: 16, Pages: 3833-3841, ISSN: 1792-1074

JOURNAL ARTICLE

Paraskevaidi M, Morais CLM, Raglan O, Lima KMG, Paraskevaidis E, Martin-Hirsch PL, Kyrgiou M, Martin FLet al., 2018, Aluminium foil as an alternative substrate for the spectroscopic interrogation of endometrial cancer, JOURNAL OF BIOPHOTONICS, Vol: 11, ISSN: 1864-063X

JOURNAL ARTICLE

Markozannes G, Kalliala I, Kyrgiou M, Tsilidis KKet al., 2018, Letter to the editor on Body mass index and 20-specific cancers-re-analyses of dose-response meta-analyses of observational studies, ANNALS OF ONCOLOGY, Vol: 29, Pages: 1490-1491, ISSN: 0923-7534

JOURNAL ARTICLE

Tzafetas M, Mitra A, Kalliala I, Lever S, Fotopoulou C, Farthing A, Smith JR, Martin-Hirsch P, Paraskevaidis E, Kyrgiou Met al., 2018, Fertility-sparing Surgery for Presumed Early-stage Invasive Cervical Cancer: A Survey of Practice in the United Kingdom, ANTICANCER RESEARCH, Vol: 38, Pages: 3641-3646, ISSN: 0250-7005

JOURNAL ARTICLE

Tzafetas M, Mitra A, Kalliala I, Bodai Z, Rosini F, Phelps D, Savage A, Lyons D, Ghaem-Maghami S, Takats Z, Kyrgiou Met al., 2018, iKinfe - improving surgical outcomes in pre-invasive and invasive cervical disease, Publisher: WILEY, Pages: 17-17, ISSN: 1470-0328

CONFERENCE PAPER

Tainio K, Athanasiou A, Tikkinen KAO, Aaltonen R, Cardenas Hernandes J, Glazer-Livson S, Jakobsson M, Joronen K, Kiviharju M, Louvanto K, Oksjoki S, Tahtinen R, Virtanen S, Nieminen P, Kyrgiou M, Kalliala Iet al., 2018, Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis, BMJ-BRITISH MEDICAL JOURNAL, Vol: 360, ISSN: 1756-1833

JOURNAL ARTICLE

Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry K-U, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss ELet al., 2017, Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis, LANCET ONCOLOGY, Vol: 18, Pages: 1665-1679, ISSN: 1470-2045

JOURNAL ARTICLE

Tainio K, Athanasiou A, Tikkinen K, Aaltonen R, Cardenas Hernandes L, Glazer-Livson S, Jakobsson M, Joronen K, Kiviharju M, Louvanto K, Oksjoki S, Tahtinen R, Virtanen S, Nieminen P, Kyrgiou M, Kalliala Iet al., 2017, Y NATURAL HISTORY OF CERVICAL INTRAEPITHELIAL NEOPLASIA GRADE 2 UNDER ACTIVE SURVEILLANCE - A SYSTEMATIC REVIEW AND META-ANALYSIS, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 893-893, ISSN: 1048-891X

CONFERENCE PAPER

Raglan O, Doria L, Soares R, Rosini F, Farrokh-Eslamlou T, McKenzie J, Takats Z, Kyrgiou Met al., 2017, ENDOMETRIAL CANCER TISSUE HAS A UNIQUE PHOSPHOLIPID SIGNATURE IDENTIFIABLE USING DESORPTION ELECTROSPRAY IONISATION (DESI) IMAGING, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 454-454, ISSN: 1048-891X

CONFERENCE PAPER

Raglan O, Doria L, Soares R, Rosini F, Farrokh-Eslamlou T, McKenzie J, Takats Z, Kyrgiou Met al., 2017, ENDOMETRIAL CANCER TISSUE HAS A UNIQUE PHOSPHOLIPID SIGNATURE IDENTIFIABLE USING DESORPTION ELECTROSPRAY IONISATION (DESI) IMAGING, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1195-1195, ISSN: 1048-891X

CONFERENCE PAPER

Tainio K, Athanasiou A, Tikkinen K, Aaltonen R, Cardenas Hernandes L, Glazer-Livson S, Jakobsson M, Joronen K, Kiviharju M, Louvanto K, Oksjoki S, Tahtinen R, Virtanen S, Nieminen P, Kyrgiou M, Kalliala Iet al., 2017, NATURAL HISTORY OF CERVICAL INTRAEPITHELIAL NEOPLASIA GRADE 2 UNDER ACTIVE SURVEILLANCE - A SYSTEMATIC REVIEW AND META-ANALYSIS, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 25-25, ISSN: 1048-891X

CONFERENCE PAPER

Arbyn M, Charles R, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss Eet al., 2017, PREDICTION OF THE OUTCOME AFTER EXCISION OF CERVICAL PRECANCER BY THE RESECTION MARGINS OR BY POST-TREATMENT HPV TESTING: A SYSTEMATIC REVIEW AND META-ANALYSIS, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1910-1910, ISSN: 1048-891X

CONFERENCE PAPER

Mitra A, MacIntyre D, Lee Y, Smith A, Marchesi J, Lyons D, Bennett P, Kyrgiou Met al., 2017, THE VAGINAL MICROBIOTA AFTER EXCISIONAL TREATMENT FOR CERVICAL INTRAEPITHELIAL NEOPLASIA, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 979-979, ISSN: 1048-891X

CONFERENCE PAPER

Nasser S, Kyrgiou M, Krell J, Haidopoulos D, Bristow R, Fotopoulou Cet al., 2017, A Review of Thoracic and Mediastinal Cytoreductive Techniques in Advanced Ovarian Cancer: Extending the Boundaries, ANNALS OF SURGICAL ONCOLOGY, Vol: 24, Pages: 3700-3705, ISSN: 1068-9265

JOURNAL ARTICLE

Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Mitra A, Terzidou V, Bennett P, Martin-Hirsch P, Tsilidis KK, Kyrgiou Met al., 2017, Obesity and gynaecological and obstetric conditions: umbrella review of the literature, BMJ-BRITISH MEDICAL JOURNAL, Vol: 359, ISSN: 1756-1833

JOURNAL ARTICLE

Kyrgiou M, Bennett P, 2017, Can we prevent preterm birth after radical trachelectomy?, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 124, Pages: 1737-1737, ISSN: 1470-0328

JOURNAL ARTICLE

Mitra A, MacIntyre DA, Mahajan V, Lee YS, Smith A, Marchesi JR, Lyons D, Bennett PR, Kyrgiou Met al., 2017, Comparison of vaginal microbiota sampling techniques: cytobrush versus swab, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Halliwell DE, Morais CLM, Lima KMG, Trevisan J, Siggel-King MRF, Craig T, Ingham J, Martin DS, Heys K, Kyrgiou M, Mitra A, Paraskevaidis E, Theophilou G, Martin-Hirsch PL, Cricenti A, Luce M, Weightman P, Martin FLet al., 2017, An imaging dataset of cervical cells using scanning near-field optical microscopy coupled to an infrared free electron laser, SCIENTIFIC DATA, Vol: 4, ISSN: 2052-4463

JOURNAL ARTICLE

Paraskevaidi M, Morais CLM, Raglan O, Lima KMG, Martin-Hirsch PL, Paraskevaidis E, Kyrgiou M, Martin FLet al., 2017, Spectroscopy of blood samples for the diagnosis of endometrial cancer and classification of its different subtypes., 53rd Annual Clinical Science Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Symposium on Old Targets, New Drugs - Her2 and MET, Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X

CONFERENCE PAPER

Domenici L, Nixon K, Sorbi F, Kyrgiou M, Yazbek J, Hall M, Campbell J, Gibbons N, Park W-HE, Gabra H, Fotopoulou Cet al., 2017, Surgery for Recurrent Uterine Cancer: Surgical Outcomes and Implications for SurvivalA Case Series, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 27, Pages: 759-767, ISSN: 1048-891X

JOURNAL ARTICLE

Paraskevaidi M, Martin-Hirsch PL, Kyrgiou M, Martin FLet al., 2017, Underlying role of mitochondrial mutagenesis in the pathogenesis of a disease and current approaches for translational research, MUTAGENESIS, Vol: 32, Pages: 335-342, ISSN: 0267-8357

JOURNAL ARTICLE

Mitra A, MacIntyre D, Lai J, Lee Y, Smith A, Marchesi J, Lyons D, Bennett P, Kyrgiou Met al., 2017, The Impact of Excisional Treatment for Cervical Intraepithelial Neoplasia on the Vaginal Microbiota., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 89A-89A, ISSN: 1933-7191

CONFERENCE PAPER

Kottaridi C, Kyrgiou M, Pouliakis A, Magkana M, Aga E, Spathis A, Mitra A, Makris G, Chrelias C, Mpakou V, Paraskevaidis E, Panayiotides JG, Karakitsos Pet al., 2017, Quantitative Measurement of L1 Human Papillomavirus Type 16 Methylation for the Prediction of Preinvasive and Invasive Cervical Disease, JOURNAL OF INFECTIOUS DISEASES, Vol: 215, Pages: 764-771, ISSN: 0022-1899

JOURNAL ARTICLE

Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KKet al., 2017, Adiposity and cancer at major anatomical sites: umbrella review of the literature, BMJ-BRITISH MEDICAL JOURNAL, Vol: 356, ISSN: 1756-1833

JOURNAL ARTICLE

Kyrgiou M, Mitra A, Moscicki A-B, 2017, Does the vaginal microbiota play a role in the development of cervical cancer?, TRANSLATIONAL RESEARCH, Vol: 179, Pages: 168-182, ISSN: 1931-5244

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00704355&limit=30&person=true