Imperial College London

Dr Maria Kyrgiou

Faculty of MedicineDepartment of Surgery & Cancer

Clinical Senior Lecturer in Gynaecological Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.kyrgiou Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

143 results found

Dardiotis E, Siokas V, Garas A, Paraskevaidis E, Kyrgiou M, Xiromerisiou G, Deligeoroglou E, Galazios G, Kontomanolis EN, Spandidos DA, Tsatsakis A, Daponte Aet al., 2018, Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions, Oncology Letters, Vol: 16, Pages: 3833-3841, ISSN: 1792-1074

© 2018, Spandidos Publications. All rights reserved. Human papillomavirus (HPV) infection alone is not sufficient to explain the development of cervical cancer. Genetic variants have been linked to the development of precancerous lesions and cervical cancer. In this study, we aimed to evaluate the association of 10 single nucleotide polymorphisms (SNPs) of the Fas cell surface death receptor (FAS), trinucleotide repeat containing 6C (TNRC6C), transmembrane channel like 8 (TMC8), DNA meiotic recombinase 1 (DMC1), deoxyuridine triphosphatase (DUT), sulfatase 1 (SULF1), 2'-5-oligoadenylate synthetase 3 (OAS3), general transcription factor IIH subunit 4 (GTF2H4) and interferon gamma (IFNG) genes with susceptibility to precancerous lesions and cervical cancer. In total, 608 female participants, consisting of 199 patients with persistent low-grade precancerous lesions(CIN1), 100 with high-grade precancerous lesions (CIN2/3), 17 patients with cervical cancer and 292 healthy controls, were enrolled in this study. SNPs were tested for associations with each of the above-mentioned cervical group lesions or when considering an overall patient group. A significant difference for rs4737999 was observed between the controls and the overall patient group considering the recessive mode of inheritance [odds ratio (OR), 0.48; 95% confidence interval (CI), 0.24- 0.96; P=0.033]. This effect was even stronger on the risk of CIN1 lesions. Carriers of the rs4737999 AA genotype were almost 3-fold less likely of having low grade lesions compared to the other genotypes. On the whole, this study provides evidence of an influence of the SULF1 gene rs4737999 SNP in the development of precancerous lesions/cervical cancer.

JOURNAL ARTICLE

Markozannes G, Kalliala I, Kyrgiou M, Tsilidis KKet al., 2018, Letter to the editor on Body mass index and 20-specific cancers-re-analyses of dose-response meta-analyses of observational studies, ANNALS OF ONCOLOGY, Vol: 29, Pages: 1490-1491, ISSN: 0923-7534

JOURNAL ARTICLE

Paraskevaidi M, Morais CLM, Raglan O, Lima KMG, Paraskevaidis E, Martin-Hirsch PL, Kyrgiou M, Martin FLet al., 2018, Aluminium foil as an alternative substrate for the spectroscopic interrogation of endometrial cancer, JOURNAL OF BIOPHOTONICS, Vol: 11, ISSN: 1864-063X

JOURNAL ARTICLE

Tainio K, Athanasiou A, Tikkinen KAO, Aaltonen R, Cardenas Hernandes J, Glazer-Livson S, Jakobsson M, Joronen K, Kiviharju M, Louvanto K, Oksjoki S, Tahtinen R, Virtanen S, Nieminen P, Kyrgiou M, Kalliala Iet al., 2018, Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis, BMJ-BRITISH MEDICAL JOURNAL, Vol: 360, ISSN: 1756-1833

JOURNAL ARTICLE

Tzafetas M, Mitra A, Kalliala I, Lever S, Fotopoulou C, Farthing A, Smith JR, Martin-Hirsch P, Paraskevaidis E, Kyrgiou Met al., 2018, Fertility-sparing Surgery for Presumed Early-stage Invasive Cervical Cancer: A Survey of Practice in the United Kingdom., Anticancer Res, Vol: 38, Pages: 3641-3646

AIM: To explore current practice in fertility-sparing surgery for cervical cancer in the UK. MATERIALS AND METHODS: A web-based structured questionnaire was designed and circulated to all members of the British Gynaecological Cancer Society. RESULTS: From 111 recipients, a total of 49 responses were collected. The majority of centres treated between 20-29 cases of invasive cervical cancer surgically (21/49, 42.9%) and performed between 0-5 cases of radical trachelectomy annually (29/49, 59.2%). The vaginal approach was the one most commonly used and was offered by almost half of the centres (21/49, 42.9%); laparoscopic techniques were offered in 13 (13/49, 26.6%). The responses were divided as to whether these cases should have been referred to supra-regional centres (25/49, 51.0%). CONCLUSION: With the use of Human Papillomavirus vaccination leading to a projected decrease in the number of cervical cancer incidence, patients may need to be referred to supraregional centres in the future.

JOURNAL ARTICLE

Arbyn M, Charles R, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss Eet al., 2017, PREDICTION OF THE OUTCOME AFTER EXCISION OF CERVICAL PRECANCER BY THE RESECTION MARGINS OR BY POST-TREATMENT HPV TESTING: A SYSTEMATIC REVIEW AND META-ANALYSIS, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1910-1910, ISSN: 1048-891X

CONFERENCE PAPER

Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry K-U, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss ELet al., 2017, Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis, LANCET ONCOLOGY, Vol: 18, Pages: 1665-1679, ISSN: 1470-2045

JOURNAL ARTICLE

Domenici L, Nixon K, Sorbi F, Kyrgiou M, Yazbek J, Hall M, Campbell J, Gibbons N, Park W-HE, Gabra H, Fotopoulou Cet al., 2017, Surgery for Recurrent Uterine Cancer: Surgical Outcomes and Implications for SurvivalA Case Series, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 27, Pages: 759-767, ISSN: 1048-891X

JOURNAL ARTICLE

Halliwell DE, Morais CLM, Lima KMG, Trevisan J, Siggel-King MRF, Craig T, Ingham J, Martin DS, Heys K, Kyrgiou M, Mitra A, Paraskevaidis E, Theophilou G, Martin-Hirsch PL, Cricenti A, Luce M, Weightman P, Martin FLet al., 2017, An imaging dataset of cervical cells using scanning near-field optical microscopy coupled to an infrared free electron laser, SCIENTIFIC DATA, Vol: 4, ISSN: 2052-4463

JOURNAL ARTICLE

Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Mitra A, Terzidou V, Bennett P, Martin-Hirsch P, Tsilidis KK, Kyrgiou Met al., 2017, Obesity and gynaecological and obstetric conditions: umbrella review of the literature, BMJ-BRITISH MEDICAL JOURNAL, Vol: 359, ISSN: 1756-1833

JOURNAL ARTICLE

Kottaridi C, Kyrgiou M, Pouliakis A, Magkana M, Aga E, Spathis A, Mitra A, Makris G, Chrelias C, Mpakou V, Paraskevaidis E, Panayiotides JG, Karakitsos Pet al., 2017, Quantitative Measurement of L1 Human Papillomavirus Type 16 Methylation for the Prediction of Preinvasive and Invasive Cervical Disease, JOURNAL OF INFECTIOUS DISEASES, Vol: 215, Pages: 764-771, ISSN: 0022-1899

JOURNAL ARTICLE

Kyrgiou M, Athanasiou A, Kalliala IEJ, Paraskevaidi M, Mitra A, Martin-Hirsch PPL, Arbyn M, Bennett P, Paraskevaidis Eet al., 2017, Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

JOURNAL ARTICLE

Kyrgiou M, Bennett P, 2017, Can we prevent preterm birth after radical trachelectomy?, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 124, Pages: 1737-1737, ISSN: 1470-0328

JOURNAL ARTICLE

Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KKet al., 2017, Adiposity and cancer at major anatomical sites: umbrella review of the literature, BMJ-BRITISH MEDICAL JOURNAL, Vol: 356, ISSN: 1756-1833

JOURNAL ARTICLE

Kyrgiou M, Kalliala I, Mitra A, Ng KYB, Raglan O, Fotopoulou C, Martin-Hirsch P, Paraskevaidis E, Arbyn Met al., 2017, Immediate referral to colposcopy versus cytological surveillance for low-grade cervical cytological abnormalities in the absence of HPV test: A systematic review and a meta-analysis of the literature, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 216-223, ISSN: 0020-7136

JOURNAL ARTICLE

Kyrgiou M, Kalliala IEJ, Mitra A, Fotopoulou C, Ghaem-Maghami S, Martin-Hirsch PPL, Cruickshank M, Arbyn M, Paraskevaidis Eet al., 2017, Immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of HPV test, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

JOURNAL ARTICLE

Kyrgiou M, Mitra A, Moscicki A-B, 2017, Does the vaginal microbiota play a role in the development of cervical cancer?, TRANSLATIONAL RESEARCH, Vol: 179, Pages: 168-182, ISSN: 1931-5244

JOURNAL ARTICLE

Mitra A, MacIntyre D, Lai J, Lee Y, Smith A, Marchesi J, Lyons D, Bennett P, Kyrgiou Met al., 2017, The Impact of Excisional Treatment for Cervical Intraepithelial Neoplasia on the Vaginal Microbiota., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 89A-89A, ISSN: 1933-7191

CONFERENCE PAPER

Mitra A, MacIntyre D, Lee Y, Smith A, Marchesi J, Lyons D, Bennett P, Kyrgiou Met al., 2017, THE VAGINAL MICROBIOTA AFTER EXCISIONAL TREATMENT FOR CERVICAL INTRAEPITHELIAL NEOPLASIA, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 979-979, ISSN: 1048-891X

CONFERENCE PAPER

Mitra A, MacIntyre DA, Mahajan V, Lee YS, Smith A, Marchesi JR, Lyons D, Bennett PR, Kyrgiou Met al., 2017, Comparison of vaginal microbiota sampling techniques: cytobrush versus swab, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Nasser S, Kyrgiou M, Krell J, Haidopoulos D, Bristow R, Fotopoulou Cet al., 2017, A Review of Thoracic and Mediastinal Cytoreductive Techniques in Advanced Ovarian Cancer: Extending the Boundaries, ANNALS OF SURGICAL ONCOLOGY, Vol: 24, Pages: 3700-3705, ISSN: 1068-9265

JOURNAL ARTICLE

Paraskevaidi M, Martin-Hirsch PL, Kyrgiou M, Martin FLet al., 2017, Underlying role of mitochondrial mutagenesis in the pathogenesis of a disease and current approaches for translational research, MUTAGENESIS, Vol: 32, Pages: 335-342, ISSN: 0267-8357

JOURNAL ARTICLE

Paraskevaidi M, Morais CLM, Raglan O, Lima KMG, Martin-Hirsch PL, Paraskevaidis E, Kyrgiou M, Martin FLet al., 2017, Spectroscopy of blood samples for the diagnosis of endometrial cancer and classification of its different subtypes., Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X

CONFERENCE PAPER

Raglan O, Doria L, Soares R, Rosini F, Farrokh-Eslamlou T, McKenzie J, Takats Z, Kyrgiou Met al., 2017, ENDOMETRIAL CANCER TISSUE HAS A UNIQUE PHOSPHOLIPID SIGNATURE IDENTIFIABLE USING DESORPTION ELECTROSPRAY IONISATION (DESI) IMAGING, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1195-1195, ISSN: 1048-891X

CONFERENCE PAPER

Raglan O, Doria L, Soares R, Rosini F, Farrokh-Eslamlou T, McKenzie J, Takats Z, Kyrgiou Met al., 2017, ENDOMETRIAL CANCER TISSUE HAS A UNIQUE PHOSPHOLIPID SIGNATURE IDENTIFIABLE USING DESORPTION ELECTROSPRAY IONISATION (DESI) IMAGING, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 454-454, ISSN: 1048-891X

CONFERENCE PAPER

Tainio K, Athanasiou A, Tikkinen K, Aaltonen R, Cardenas Hernandes L, Glazer-Livson S, Jakobsson M, Joronen K, Kiviharju M, Louvanto K, Oksjoki S, Tahtinen R, Virtanen S, Nieminen P, Kyrgiou M, Kalliala Iet al., 2017, Y NATURAL HISTORY OF CERVICAL INTRAEPITHELIAL NEOPLASIA GRADE 2 UNDER ACTIVE SURVEILLANCE - A SYSTEMATIC REVIEW AND META-ANALYSIS, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 893-893, ISSN: 1048-891X

CONFERENCE PAPER

Tainio K, Athanasiou A, Tikkinen K, Aaltonen R, Cardenas Hernandes L, Glazer-Livson S, Jakobsson M, Joronen K, Kiviharju M, Louvanto K, Oksjoki S, Tahtinen R, Virtanen S, Nieminen P, Kyrgiou M, Kalliala Iet al., 2017, NATURAL HISTORY OF CERVICAL INTRAEPITHELIAL NEOPLASIA GRADE 2 UNDER ACTIVE SURVEILLANCE - A SYSTEMATIC REVIEW AND META-ANALYSIS, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 25-25, ISSN: 1048-891X

CONFERENCE PAPER

Farthing A, Kyrgiou M, 2016, Re: Laparoscopic radical abdominal trachelectomy for the management of stage IB1 cervical cancer at 14 weeks gestation: case report and review of the literature Reply, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 646-646, ISSN: 1470-0328

JOURNAL ARTICLE

Fotopoulou C, Jones BP, Savvatis K, Campbell J, Kyrgiou M, Farthing A, Brett S, Roux R, Hall M, Rustin G, Gabra H, Jiao L, Stumpfle Ret al., 2016, Maximal effort cytoreductive surgery for disseminated ovarian cancer in a UK setting: challenges and possibilities, ARCHIVES OF GYNECOLOGY AND OBSTETRICS, Vol: 294, Pages: 607-614, ISSN: 0932-0067

JOURNAL ARTICLE

Halliwell DE, Kyrgiou M, Mitra A, Kalliala I, Paraskevaidis E, Theophilou G, Martin-Hirsch PL, Martin FLet al., 2016, Tracking the Impact of Excisional Cervical Treatment on the Cervix using Biospectroscopy, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

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