Imperial College London

Dr Maria Kyrgiou

Faculty of MedicineDepartment of Surgery & Cancer

Clinical Senior Lecturer in Gynaecological Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.kyrgiou Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

125 results found

Kyrgiou M, Kalliala I, Markozannes G, Gunter M, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis Ket al., Adiposity and cancer at all anatomic sites: an umbrella review of the literature, British Medical Journal, ISSN: 1468-5833

Objective: Although meta-analyses support associations between obesity and several cancers, some of the claimed associations may be flawed due to inherent biases. We evaluated strength and validity of the evidence for adiposity and risk of cancer development and mortality using an umbrella review methodology.Methods:Design: An umbrella review of systematic reviews and meta-analyses.Data sources: PubMed, EMBASE, Cochrane database of systematic reviews and manual screening. Eligibility criteria for selecting studies: Systematic reviews or meta-analyses of observational studies that evaluated the association between indices of adiposity and risk of developing or dying from cancer. Main Outcomes: Primary analysis focused on cohort studies exploring associations for continuous contrasts of adiposity. Data synthesis: The evidence was graded into strong, highly suggestive, suggestive or weak after applying criteria that included the statistical significance of the random effects summary estimate and of the largest study in a meta-analysis, the number of cancer cases, between-study heterogeneity, 95% prediction intervals, small study effects, excess significance bias and sensitivity analysis with credibility ceilings.Results: 204 meta-analyses investigated associations between seven indices of adiposity and the development or death from 36 primary cancers and their sub-types. Of the 95 meta-analyses that included cohort studies and used a continuous scale to measure adiposity, 12 (13%) associations for nine cancers demonstrated strong evidence. Elevated BMI was associated with a higher risk of developing oesophageal adenocarcinoma, colon and rectal cancer in men, biliary tract, pancreatic, endometrial cancer in pre-menopausal women, kidney cancer and multiple myeloma. Weight gain and waist to hip circumference ratio were associated with a higher risk of post-menopausal breast cancer in women who have never used hormone replacement therapy and endometrial cancer, respectivel

JOURNAL ARTICLE

Kyrgiou M, Mitra A, Paraskevaidis E, The Impact of Conservative Treatment for Cervical Intraepithelial Neoplasia and Early Cervical Cancer on Fertility and Early Pregnancy Outcomes, JAMA Oncology, ISSN: 2374-2445

Clinical Question: Does local conservative treatment for cervical intraepithelial neoplasia and early invasive cervical cancer adversely affect successful conception and early pregnancy outcomes in the first and second trimester (less than 24 weeks of gestation)?Clinical Application: Local cervical treatment does not adversely affect fertility or first trimester miscarriage, although it is associated with a significant increase in the risk of second trimester miscarriages.

JOURNAL ARTICLE

Domenici L, Nixon K, Sorbi F, Kyrgiou M, Yazbek J, Hall M, Campbell J, Gibbons N, Park W-HE, Gabra H, Fotopoulou Cet al., 2017, Surgery for Recurrent Uterine Cancer: Surgical Outcomes and Implications for SurvivalA Case Series, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 27, Pages: 759-767, ISSN: 1048-891X

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Halliwell DE, Morais CLM, Lima KMG, Trevisan J, Siggel-King MRF, Craig T, Ingham J, Martin DS, Heys K, Kyrgiou M, Mitra A, Paraskevaidis E, Theophilou G, Martin-Hirsch PL, Cricenti A, Luce M, Weightman P, Martin FLet al., 2017, An imaging dataset of cervical cells using scanning near-field optical microscopy coupled to an infrared free electron laser, SCIENTIFIC DATA, Vol: 4, ISSN: 2052-4463

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Kottaridi C, Kyrgiou M, Pouliakis A, Magkana M, Aga E, Spathis A, Mitra A, Makris G, Chrelias C, Mpakou V, Paraskevaidis E, Panayiotides JG, Karakitsos Pet al., 2017, Quantitative Measurement of L1 Human Papillomavirus Type 16 Methylation for the Prediction of Preinvasive and Invasive Cervical Disease, JOURNAL OF INFECTIOUS DISEASES, Vol: 215, Pages: 764-771, ISSN: 0022-1899

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Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KKet al., 2017, Adiposity and cancer at major anatomical sites: umbrella review of the literature, BMJ-BRITISH MEDICAL JOURNAL, Vol: 356, ISSN: 1756-1833

JOURNAL ARTICLE

Kyrgiou M, Kalliala I, Mitra A, Ng KYB, Raglan O, Fotopoulou C, Martin-Hirsch P, Paraskevaidis E, Arbyn Met al., 2017, Immediate referral to colposcopy versus cytological surveillance for low-grade cervical cytological abnormalities in the absence of HPV test: A systematic review and a meta-analysis of the literature, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 216-223, ISSN: 0020-7136

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Kyrgiou M, Kalliala IEJ, Mitra A, Fotopoulou C, Ghaem-Maghami S, Martin-Hirsch PPL, Cruickshank M, Arbyn M, Paraskevaidis Eet al., 2017, Immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of HPV test, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

JOURNAL ARTICLE

Kyrgiou M, Mitra A, Moscicki A-B, 2017, Does the vaginal microbiota play a role in the development of cervical cancer?, TRANSLATIONAL RESEARCH, Vol: 179, Pages: 168-182, ISSN: 1931-5244

JOURNAL ARTICLE

Mitra A, MacIntyre D, Lai J, Lee Y, Smith A, Marchesi J, Lyons D, Bennett P, Kyrgiou Met al., 2017, The Impact of Excisional Treatment for Cervical Intraepithelial Neoplasia on the Vaginal Microbiota., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 89A-89A, ISSN: 1933-7191

CONFERENCE PAPER

Mitra A, MacIntyre DA, Mahajan V, Lee YS, Smith A, Marchesi JR, Lyons D, Bennett PR, Kyrgiou Met al., 2017, Comparison of vaginal microbiota sampling techniques: cytobrush versus swab, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Paraskevaidi M, Martin-Hirsch PL, Kyrgiou M, Martin FLet al., 2017, Underlying role of mitochondrial mutagenesis in the pathogenesis of a disease and current approaches for translational research, MUTAGENESIS, Vol: 32, Pages: 335-342, ISSN: 0267-8357

JOURNAL ARTICLE

Farthing A, Kyrgiou M, 2016, Re: Laparoscopic radical abdominal trachelectomy for the management of stage IB1 cervical cancer at 14 weeks gestation: case report and review of the literature Reply, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 646-646, ISSN: 1470-0328

JOURNAL ARTICLE

Fotopoulou C, Jones BP, Savvatis K, Campbell J, Kyrgiou M, Farthing A, Brett S, Roux R, Hall M, Rustin G, Gabra H, Jiao L, Stumpfle Ret al., 2016, Maximal effort cytoreductive surgery for disseminated ovarian cancer in a UK setting: challenges and possibilities, ARCHIVES OF GYNECOLOGY AND OBSTETRICS, Vol: 294, Pages: 607-614, ISSN: 0932-0067

JOURNAL ARTICLE

Halliwell DE, Kyrgiou M, Mitra A, Kalliala I, Paraskevaidis E, Theophilou G, Martin-Hirsch PL, Martin FLet al., 2016, Tracking the Impact of Excisional Cervical Treatment on the Cervix using Biospectroscopy, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

Halliwell DE, Morais CLM, Lima KMG, Trevisan J, Siggel-King MRF, Craig T, Ingham J, Martin DS, Heys KA, Kyrgiou M, Mitra A, Paraskevaidis E, Theophilou G, Martin-Hirsch PL, Cricenti A, Luce M, Weightman P, Martin FLet al., 2016, Imaging cervical cytology with scanning near-field optical microscopy (SNOM) coupled with an IR-FEL, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

Kalliala I, Tsilidis K, Kyrgiou M, 2016, Obesity and Gynaecological Cancer - An Umbrella Review and Meta-Analysis., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 179A-179A, ISSN: 1933-7191

CONFERENCE PAPER

Kindinger LM, Kyrgiou M, MacIntyre DA, Cacciatore S, Yulia A, Cook J, Terzidou V, Teoh TG, Bennett PRet al., 2016, Preterm Birth Prevention Post-Conization: A Model of Cervical Length Screening with Targeted Cerclage, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Kyrgiou M, Athanasiou A, Paraskevadi M, Arbyn M, Mitra A, Martin-Hirsch P, Bennett P, Paraskevaidis Eet al., 2016, Risk of Preterm Birth After Treatment for Cervical Precancer Increases with Increasing Cone Depth: Systematic Review and Meta-Analysis., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 189A-190A, ISSN: 1933-7191

CONFERENCE PAPER

Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis Eet al., 2016, Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis, BMJ-BRITISH MEDICAL JOURNAL, Vol: 354, ISSN: 1756-1833

JOURNAL ARTICLE

Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis Eet al., 2016, Adverse Obstetric Outcomes After Local Treatment for Cervical Preinvasive and Early Invasive Disease According to Cone Depth: Systematic Review and Meta-analysis EDITORIAL COMMENT, OBSTETRICAL & GYNECOLOGICAL SURVEY, Vol: 71, Pages: 646-648, ISSN: 0029-7828

JOURNAL ARTICLE

Kyrgiou M, Mitra A, Athanasiou A, Paraskevaidi M, Arbyn M, Martin-Hirsch P, Bennett P, Paraskevaidis Eet al., 2016, The risk of preterm birth after treatment for cervical pre-invasive and early invasive disease increases with increasing cone depth: a systematic review and meta-analysis, Publisher: WILEY-BLACKWELL, Pages: E8-E8, ISSN: 1470-0328

CONFERENCE PAPER

Kyrgiou M, Mitra A, Paraskevaidis E, 2016, Fertility and Early Pregnancy Outcomes Following Conservative Treatment for Cervical Intraepithelial Neoplasia and Early Cervical Cancer, JAMA ONCOLOGY, Vol: 2, Pages: 1496-1498, ISSN: 2374-2437

JOURNAL ARTICLE

Kyrgiou M, Pouliakis A, Panayiotides JG, Margari N, Bountris P, Valasoulis G, Paraskevaidi M, Bilirakis E, Nasioutziki M, Loufopoulos A, Haritou M, Koutsouris DD, Karakitsos P, Paraskevaidis Eet al., 2016, Personalised management of women with cervical abnormalities using a clinical decision support scoring system, GYNECOLOGIC ONCOLOGY, Vol: 141, Pages: 29-35, ISSN: 0090-8258

JOURNAL ARTICLE

Mitra A, Kindinger L, Kalliala I, Smith JR, Paraskevaidis E, Bennett PR, Kyrgiou Met al., 2016, Obstetric complications after treatment of cervical intraepithelial neoplasia, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 77, Pages: C124-C127, ISSN: 1750-8460

JOURNAL ARTICLE

Mitra A, MacIntyre D, Lee Y, Smith A, Marchesi J, Lehne B, Bhatia R, Lyons D, Paraskevaidis E, Holmes E, Nicholson J, Bennett P, Kyrgiou Met al., 2016, Cervical Intraepithelial Neoplasia Disease Progression Is Associated with Increased Vaginal Microbiome Diversity., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 66A-66A, ISSN: 1933-7191

CONFERENCE PAPER

Mitra A, MacIntyre D, Lee Y, Smith A, Marchesi J, Lehne B, Bhatia R, Lyons D, Paraskevaidis E, Holmes E, Nicholson J, Bennett P, Kyrgiou Met al., 2016, Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity, Publisher: WILEY-BLACKWELL, Pages: E11-E12, ISSN: 1470-0328

CONFERENCE PAPER

Mitra A, MacIntyre DA, Marchesi JR, Lee YS, Bennett PR, Kyrgiou Met al., 2016, The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?, MICROBIOME, Vol: 4, ISSN: 2049-2618

JOURNAL ARTICLE

Mitra A, Maclntyre D, Lee Y, Smith A, Marchesi J, Lehne B, Bhatia R, Lyons D, Paraskevaidis E, Li J, Holmes E, Nicholson J, Bennett P, Kyrgiou Met al., 2016, Characterisation of the vaginal microbiome in cervical intraepithelial neoplasia, LANCET, Vol: 387, Pages: 75-75, ISSN: 0140-6736

JOURNAL ARTICLE

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