Imperial College London

ProfessorMichaelLevin

Faculty of MedicineDepartment of Medicine

Chair in Paediatrics & International Child Health
 
 
 
//

Contact

 

+44 (0)20 7594 3760m.levin

 
 
//

Location

 

233Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Publication Type
Year
to

235 results found

Bellos E, Herberg J, Wright V, Klobassa D, Mashbat M, Rahman R, Schlapbach L, Pouw R, Kuijpers T, Levin M, Sancho-Shimizu Vet al., 2018, The genetic basis of invasive meningococcal disease revealed thorough whole exome sequencing, Publisher: BIOMED CENTRAL LTD, ISSN: 1473-9542

CONFERENCE PAPER

Brent AJ, Mugo D, Musyimi R, Mutiso A, Morpeth SC, Levin M, Scott JAGet al., 2018, Bacteriological diagnosis of childhood TB: a prospective observational study (vol 7, 2017), SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Brent AJ, Nyundo C, Langat J, Mulunda C, Wambua J, Bauni E, Sande J, Park K, Williams TN, Newton CRJ, Levin M, Scott JAGet al., 2018, Prospective Observational Study of Incidence and Preventable Burden of Childhood Tuberculosis, Kenya, EMERGING INFECTIOUS DISEASES, Vol: 24, Pages: 514-523, ISSN: 1080-6040

JOURNAL ARTICLE

Chen KYH, Messina N, Germano S, Bonnici R, Freyne B, Cheung M, Goldsmith G, Kollmann TR, Levin M, Burgner D, Curtis Net al., 2018, Innate immune responses following Kawasaki disease and toxic shock syndrome, PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJMet al., 2018, Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza, NATURE IMMUNOLOGY, Vol: 19, Pages: 625-+, ISSN: 1529-2908

JOURNAL ARTICLE

Gliddon HD, Herberg JA, Levin M, Kaforou Met al., 2018, Genome-wide host RNA signatures of infectious diseases: discovery and clinical translation, IMMUNOLOGY, Vol: 153, Pages: 171-178, ISSN: 0019-2805

JOURNAL ARTICLE

Lee HJ, Georgiadou A, Otto TD, Levin M, Coin LJ, Conway DJ, Cunnington AJet al., 2018, Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions, MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, Vol: 82, ISSN: 1092-2172

JOURNAL ARTICLE

Martinón-Torres F, Salas A, Rivero-Calle I, Cebey-López M, Pardo-Seco J, Herberg JA, Boeddha NP, Klobassa DS, Secka F, Paulus S, de Groot R, Schlapbach LJ, Driessen GJ, Anderson ST, Emonts M, Zenz W, Carrol ED, Van der Flier M, Levin M, Levin M, Coin L, Gormley S, Hamilton S, Herberg J, Hourmat B, Hoggart C, Kaforou M, Sancho-Shimizu V, Wright V, Abdulla A, Agapow P, Bartlett M, Bellos E, Eleftherohorinou H, Galassini R, Inwald D, Mashbat M, Menikou S, Mustafa S, Nadel S, Rahman R, Thakker C, Bokhandi S, Power S, Barham H, Pathan N, Ridout J, White D, Thurston S, Faust S, Patel S, McCorkell J, Davies P, Crate L, Navarra H, Carter S, Ramaiah R, Patel R, Tuffrey C, Gribbin A, McCready S, Peters M, Hardy K, Standing F, O'Neill L, Abelake E, Deep A, Nsirim E, Pollard A, Willis L, Young Z, Royad C, White S, Fortune PM, Hudnott P, Martinón-Torres F, Salas Ellacuriaga A, Álvez González F, Barral-Arca R, Cebey-López M, Curras-Tuala MJ, García N, García Vicente L, Gómez-Carballa A, Gómez Rial J, Grela Beiroa A, Justicia Grande A, Leboráns Iglesias P, Martínez Santos AE, Martinón-Torres N, Martinón Sánchez JM, Morillo Gutiérrez Bet al., 2018, Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study, The Lancet Child and Adolescent Health, Vol: 2, Pages: 404-414

© 2018 Elsevier Ltd Background: Sepsis and severe focal infections represent a substantial disease burden in children admitted to hospital. We aimed to understand the burden of disease and outcomes in children with life-threatening bacterial infections in Europe. Methods: The European Union Childhood Life-threatening Infectious Disease Study (EUCLIDS) was a prospective, multicentre, cohort study done in six countries in Europe. Patients aged 1 month to 18 years with sepsis (or suspected sepsis) or severe focal infections, admitted to 98 participating hospitals in the UK, Austria, Germany, Lithuania, Spain, and the Netherlands were prospectively recruited between July 1, 2012, and Dec 31, 2015. To assess disease burden and outcomes, we collected demographic and clinical data using a secured web-based platform and obtained microbiological data using locally available clinical diagnostic procedures. Findings: 2844 patients were recruited and included in the analysis. 1512 (53·2%) of 2841 patients were male and median age was 39·1 months (IQR 12·4–93·9). 1229 (43·2%) patients had sepsis and 1615 (56·8%) had severe focal infections. Patients diagnosed with sepsis had a median age of 27·6 months (IQR 9·0–80·2), whereas those diagnosed with severe focal infections had a median age of 46·5 months (15·8–100·4; p < 0·0001). Of 2844 patients in the entire cohort, the main clinical syndromes were pneumonia (511 [18·0%] patients), CNS infection (469 [16·5%] ), and skin and soft tissue infection (247 [8·7%]). The causal microorganism was identified in 1359 (47·8%) children, with the most prevalent ones being Neisseria meningitidis (in 259 [9·1%] patients), followed by Staphylococcus aureus (in 222 [7·8%]), Streptococcus pneumoniae (in 219 [7·7%] ), and group A streptococcus (in 162 [5·7%]). 1070 (37·6%

JOURNAL ARTICLE

Mashbat B, Bellos E, Bidmos F, Tarran R, Lu Y, Wright V, Herberg J, Langford P, Schlapbach L, Li M-S, Di P, Levin M, Sancho-Shimizu Vet al., 2018, Whole exome sequencing identifies BPIFA1 mutation underlying invasive meningococcal disease, Publisher: BIOMED CENTRAL LTD, ISSN: 1473-9542

CONFERENCE PAPER

von Both U, Berk M, Agapow P-M, Wright JD, Git A, Hamilton MS, Goldgof G, Siddiqui N, Bellos E, Wright VJ, Coin LJ, Newton SM, Levin Met al., 2018, &IT Mycobacterium tuberculosis&IT Exploits a Molecular &ITOffSwitch&IT of the Immune System for Intracellular Survival, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Brent AJ, Mugo D, Musyimi R, Mutiso A, Morpeth S, Levin M, Scott JAGet al., 2017, Bacteriological diagnosis of childhood TB: a prospective observational study, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Dietz SM, van Stijn D, Burgner D, Levin M, Kuipers IM, Hutten BA, Kuijpers TWet al., 2017, Dissecting Kawasaki disease: a state-of-the-art review, EUROPEAN JOURNAL OF PEDIATRICS, Vol: 176, Pages: 995-1009, ISSN: 0340-6199

JOURNAL ARTICLE

Hemingway C, Berk M, Anderson ST, Wright VJ, Hamilton S, Eleftherohorinou H, Kaforou M, Goldgof GM, Hickman K, Kampmann B, Schoeman J, Eley B, Beatty D, Pienaar S, Nicol MP, Griffiths MJ, Waddell SJ, Newton SM, Coin LJ, Relman DA, Montana G, Levin Met al., 2017, Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function, PLOS ONE, Vol: 12, ISSN: 1932-6203

JOURNAL ARTICLE

Israel L, Wang Y, Bulek K, Della Mina E, Zhang Z, Pedergnana V, Chrabieh M, Lemmens NA, Sancho-Shimizu V, Descatoire M, Lasseau T, Israelsson E, Lorenzo L, Yun L, Belkadi A, Moran A, Weisman LE, Vandenesch F, Batteux F, Weller S, Levin M, Herberg J, Abhyankar A, Prando C, Itan Y, van Wamel WJB, Picard C, Abel L, Chaussabel D, Li X, Beutler B, Arkwright PD, Casanova J-L, Puel Aet al., 2017, Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity, CELL, Vol: 168, Pages: 789-+, ISSN: 0092-8674

JOURNAL ARTICLE

Kaforou M, Herberg JA, Wright VJ, Coin LJM, Levin Met al., 2017, Diagnosis of Bacterial Infection Using a 2-Transcript Host RNA Signature in Febrile Infants 60 Days or Younger, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 317, Pages: 1577-1578, ISSN: 0098-7484

JOURNAL ARTICLE

Kaufmann SHE, Dockrell HM, Drager N, Ho MM, McShane H, Neyrolles O, Ottenhoff THM, Patel B, Roordink D, Spertini F, Stenger S, Thole J, Verreck FAW, Williams Aet al., 2017, TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development, FRONTIERS IN IMMUNOLOGY, Vol: 8, ISSN: 1664-3224

JOURNAL ARTICLE

Shimizu C, Kim J, Eleftherohorinou H, Wright V, Hoang L, Tremoulet A, Franco A, Hibberd M, Takahashi A, Kubo M, Ito K, Tanaka T, Onouchi Y, Coin L, Levin M, Burns J, Shike Het al., 2017, Genetic Variants in HLA-C and Class I Pathway Genes Influence Susceptibility to Kawasaki Disease, Publisher: WILEY, ISSN: 2326-5191

CONFERENCE PAPER

Gliddon HD, Howes PD, Kaforou M, Levin M, Stevens MMet al., 2016, A nucleic acid strand displacement system for the multiplexed detection of tuberculosis-specific mRNA using quantum dots, NANOSCALE, Vol: 8, Pages: 10087-10095, ISSN: 2040-3364

JOURNAL ARTICLE

Herberg JA, Kaforou M, Wright VJ, Shailes H, Eleftherohorinou H, Hoggart CJ, Cebey-Lopez M, Carter MJ, Janes VA, Gormley S, Shimizu C, Tremoulet AH, Barendregt AM, Salas A, Kanegaye J, Pollard AJ, Faust SN, Patel S, Kuijpers T, Martinon-Torres F, Burns JC, Coin LJM, Levin Met al., 2016, Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 316, Pages: 835-845, ISSN: 0098-7484

JOURNAL ARTICLE

Levin M, Kaforou M, 2016, Predicting active tuberculosis progression by RNA analysis, LANCET, Vol: 387, Pages: 2268-2270, ISSN: 0140-6736

JOURNAL ARTICLE

Martinon-Torres F, Png E, Khor CC, Davila S, Wright VJ, Sim KS, Vega A, Fachal L, Inwald D, Nadel S, Carrol ED, Martinon-Torres N, Marcos Alonso S, Carracedo A, Morteruel E, Lopez-Bayon J, Concha Torre A, Calvo Monge C, Gonzalez de Aguilar PA, Esteban Torne E, del Carmen Martinez-Padilla M, Maria Martinon-Sanchez J, Levin M, Hibberd ML, Salas Aet al., 2016, Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

McDonald JU, Kaforou M, Clare S, Hale C, Ivanova M, Huntley D, Dorner M, Wright VJ, Levin M, Martinon-Torres F, Herberg JA, Tregoning JSet al., 2016, A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease, MSYSTEMS, Vol: 1, ISSN: 2379-5077

JOURNAL ARTICLE

Seaby EG, Wright VJ, Levin M, 2016, Genome-wide Association Studies in Infectious Diseases, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 35, Pages: 802-804, ISSN: 0891-3668

JOURNAL ARTICLE

Shimizu C, Eleftherohorinou H, Wright VJ, Kim J, Alphonse MP, Perry JC, Cimaz R, Burgner D, Dahdah N, Hoang LT, Khor CC, Salgado A, Tremoulet AH, Davila S, Kuijpers TW, Hibberd ML, Johnson TA, Takahashi A, Tsunoda T, Kubo M, Tanaka T, Onouchi Y, Yeung RSM, Coin LJM, Levin M, Burns JCet al., 2016, Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities, CIRCULATION-CARDIOVASCULAR GENETICS, Vol: 9, Pages: 559-+, ISSN: 1942-325X

JOURNAL ARTICLE

Davies S, Sutton N, Blackstock S, Gormley S, Hoggart CJ, Levin M, Herberg JAet al., 2015, Predicting IVIG resistance in UK Kawasaki disease, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 100, Pages: 366-368, ISSN: 0003-9888

JOURNAL ARTICLE

Eleftheriou D, Levin M, Shingadia D, Tulloh R, Klein N, Brogan Pet al., 2015, Authors' response to 'Aspirin dose for treatment of Kawasaki disease', ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 100, ISSN: 0003-9888

JOURNAL ARTICLE

Evans C, Orf K, Horvath E, Levin M, De La Fuente J, Chakravorty S, Cunnington AJet al., 2015, Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1, HAEMATOLOGICA, Vol: 100, Pages: 1508-1516, ISSN: 0390-6078

JOURNAL ARTICLE

George EC, Walker AS, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H, Berkley JA, Mpoya A, Levin M, Crawley J, Gibb DM, Maitland K, Babiker AGet al., 2015, Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score, BMC MEDICINE, Vol: 13, ISSN: 1741-7015

JOURNAL ARTICLE

Kiguli S, Maitland K, George EC, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H, Levin M, Babiker AG, Gibb DM, Crawley Jet al., 2015, Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness, BMC MEDICINE, Vol: 13, ISSN: 1741-7015

JOURNAL ARTICLE

Nicol MP, Gnanashanmugam D, Browning R, Click ES, Cuevas LE, Detjen A, Graham SM, Levin M, Makhene M, Nahid P, Perez-Velez CM, Reither K, Song R, Spiegel HML, Worrell C, Zar HJ, Walzl Get al., 2015, A Blueprint to Address Research Gaps in the Development of Biomarkers for Pediatric Tuberculosis, CLINICAL INFECTIOUS DISEASES, Vol: 61, Pages: S164-S172, ISSN: 1058-4838

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00104439&limit=30&person=true