Imperial College London

ProfessorMichaelLevin

Faculty of MedicineDepartment of Medicine

Chair in Paediatrics & International Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3760m.levin

 
 
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Location

 

233Medical SchoolSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

242 results found

Bellos E, Herberg J, Wright V, Klobassa D, Mashbat M, Rahman R, Schlapbach L, Pouw R, Kuijpers T, Levin M, Sancho-Shimizu Vet al., 2018, The genetic basis of invasive meningococcal disease revealed thorough whole exome sequencing, Publisher: BIOMED CENTRAL LTD, ISSN: 1473-9542

CONFERENCE PAPER

Boeddha NP, Schlapbach LJ, Driessen GJ, Herberg JA, Rivero-Calle I, Cebey-Lopez M, Klobassa DS, Philipsen R, de Groot R, Inwald DP, Nadel S, Paulus S, Pinnock E, Secka F, Anderson ST, Agbeko RS, Berger C, Fink CG, Carrol ED, Zenz W, Levin M, van der Flier M, Martinon-Torres F, Hazelzet JA, Emonts Met al., 2018, Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS), CRITICAL CARE, Vol: 22, ISSN: 1466-609X

JOURNAL ARTICLE

Brent AJ, Mugo D, Musyimi R, Mutiso A, Morpeth SC, Levin M, Scott JAGet al., 2018, Bacteriological diagnosis of childhood TB: a prospective observational study (vol 7, 2017), SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Brent AJ, Nyundo C, Langat J, Mulunda C, Wambua J, Bauni E, Sande J, Park K, Williams TN, Newton CRJ, Levin M, Scott JAGet al., 2018, Prospective Observational Study of Incidence and Preventable Burden of Childhood Tuberculosis, Kenya, EMERGING INFECTIOUS DISEASES, Vol: 24, Pages: 514-523, ISSN: 1080-6040

JOURNAL ARTICLE

Chen KYH, Messina N, Germano S, Bonnici R, Freyne B, Cheung M, Goldsmith G, Kollmann TR, Levin M, Burgner D, Curtis Net al., 2018, Innate immune responses following Kawasaki disease and toxic shock syndrome, PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJMet al., 2018, Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza, NATURE IMMUNOLOGY, Vol: 19, Pages: 625-+, ISSN: 1529-2908

JOURNAL ARTICLE

Gliddon HD, Herberg JA, Levin M, Kaforou Met al., 2018, Genome-wide host RNA signatures of infectious diseases: discovery and clinical translation, IMMUNOLOGY, Vol: 153, Pages: 171-178, ISSN: 0019-2805

JOURNAL ARTICLE

Lee HJ, Georgiadou A, Otto TD, Levin M, Coin LJ, Conway DJ, Cunnington AJet al., 2018, Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions, MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, Vol: 82, ISSN: 1092-2172

JOURNAL ARTICLE

Lee HJ, Georgiadou A, Walther M, Nwakanma D, Stewart LB, Levin M, Otto TD, Conway DJ, Coin LJ, Cunnington AJet al., 2018, Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria, SCIENCE TRANSLATIONAL MEDICINE, Vol: 10, ISSN: 1946-6234

JOURNAL ARTICLE

Martinon-Torres F, Salas A, Rivero-Calle I, Cebey-Lopez M, Pardo-Seco J, Herberg JA, Boeddha NP, Klobassa DS, Secka F, Paulus S, de Groot R, Schlapbach LJ, Driessen GJ, Anderson ST, Emonts M, Zenz W, Carrol ED, Van der Flier M, Levin Met al., 2018, Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study, LANCET CHILD & ADOLESCENT HEALTH, Vol: 2, Pages: 404-414, ISSN: 2352-4642

JOURNAL ARTICLE

Mashbat B, Bellos E, Bidmos F, Tarran R, Lu Y, Wright V, Herberg J, Langford P, Schlapbach L, Li M-S, Di P, Levin M, Sancho-Shimizu Vet al., 2018, Whole exome sequencing identifies BPIFA1 mutation underlying invasive meningococcal disease, Publisher: BIOMED CENTRAL LTD, ISSN: 1473-9542

CONFERENCE PAPER

Tulloh RMR, Mayon-White R, Harnden A, Ramanan AV, Tizard EJ, Shingadia D, Michie CA, Lynn RM, Levin M, Franklin OD, Craggs P, Davidson S, Stirzaker R, Danson M, Brogan PAet al., 2018, Kawasaki disease: a prospective population survey in the UK and Ireland from 2013 to 2015., Arch Dis Child

OBJECTIVE: Kawasaki disease (KD) is an increasingly common vasculitis with risk of coronary artery aneurysms (CAAs). The last UK survey was in 1990, whereas current epidemiology, treatment patterns and complication rates are unknown. The aim of this study was to address this knowledge gap. METHODS: A British Paediatric Surveillance Unit survey in the UK and Ireland from 1 January 2013 to 28 February 2015 ascertained demographics, ethnicity, seasonal incidence, treatment and complication rates. RESULTS: 553 cases were notified: 389 had complete KD, 46 had atypical KD and 116 had incomplete KD; 2 were diagnosed at postmortem with an incidence of 4.55/100 000 children under 5 years, with a male to female ratio of 1.5:1 and a median age of 2.7 years (2.5 months-15 years). Presentation was highest in January and in rural areas. Most were white (64%), and Chinese and Japanese Asians were over-represented as were black African or African mixed-race children. 94% received intravenous immunoglobulin (IVIG). The overall CAA rate was 19%, and all-cardiac complications affected 28%. Those with CAA received IVIG later than in those without (median 10 days vs 7 days). Those under 1 year had fewer symptoms, but the highest CAA rate (39%). Overall 8 of 512 cases (1.6%) had giant CAA, and 4 of 86 cases (5%) under 1 year of age developed giant CAA. Mortality from KD was 0.36%. CONCLUSIONS: The UK and Ireland incidence of KD has increased and is more frequently seen in winter and rural areas. Delayed IVIG treatment is associated with CAA, suggesting earlier and adjunctive primary treatment might reduce complications to prevent CAA, particularly in the very young.

JOURNAL ARTICLE

Wright VJ, Herberg JA, Kaforou M, Shimizu C, Eleftherohorinou H, Shailes H, Barendregt AM, Menikou S, Gormley S, Berk M, Hoang LT, Tremoulet AH, Kanegaye JT, Coin LJM, Glodé MP, Hibberd M, Kuijpers TW, Hoggart CJ, Burns JC, Levin M, Immunopathology of Respiratory, Inflammatory and Infectious Disease Study IRIS Consortium and the Pediatric Emergency Medicine Kawasaki Disease Research Group PEMKDRGet al., 2018, Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature., JAMA Pediatr

Importance: To date, there is no diagnostic test for Kawasaki disease (KD). Diagnosis is based on clinical features shared with other febrile conditions, frequently resulting in delayed or missed treatment and an increased risk of coronary artery aneurysms. Objective: To identify a whole-blood gene expression signature that distinguishes children with KD in the first week of illness from other febrile conditions. Design, Setting, and Participants: The case-control study comprised a discovery group that included a training and test set and a validation group of children with KD or comparator febrile illness. The setting was pediatric centers in the United Kingdom, Spain, the Netherlands, and the United States. The training and test discovery group comprised 404 children with infectious and inflammatory conditions (78 KD, 84 other inflammatory diseases, and 242 bacterial or viral infections) and 55 healthy controls. The independent validation group comprised 102 patients with KD, including 72 in the first 7 days of illness, and 130 febrile controls. The study dates were March 1, 2009, to November 14, 2013, and data analysis took place from January 1, 2015, to December 31, 2017. Main Outcomes and Measures: Whole-blood gene expression was evaluated using microarrays, and minimal transcript sets distinguishing KD were identified using a novel variable selection method (parallel regularized regression model search). The ability of transcript signatures (implemented as disease risk scores) to discriminate KD cases from controls was assessed by area under the curve (AUC), sensitivity, and specificity at the optimal cut point according to the Youden index. Results: Among 404 patients in the discovery set, there were 78 with KD (median age, 27 months; 55.1% male) and 326 febrile controls (median age, 37 months; 56.4% male). Among 202 patients in the validation set, there were 72 with KD (median age, 34 months; 62.5% male) and 130 febrile controls (median age, 17 months; 56.9%

JOURNAL ARTICLE

van Beek AE, Sarr I, Correa S, Nwakanma D, Brouwer MC, Wouters D, Secka F, Anderson STB, Conway DJ, Walther M, Levin M, Kuijpers TW, Cunnington AJet al., 2018, Complement Factor H Levels Associate With Plasmodium falciparum Malaria Susceptibility and Severity, OPEN FORUM INFECTIOUS DISEASES, Vol: 5, ISSN: 2328-8957

JOURNAL ARTICLE

von Both U, Berk M, Agapow P-M, Wright JD, Git A, Hamilton MS, Goldgof G, Siddiqui N, Bellos E, Wright VJ, Coin LJ, Newton SM, Levin Met al., 2018, &IT Mycobacterium tuberculosis&IT Exploits a Molecular &ITOffSwitch&IT of the Immune System for Intracellular Survival, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Brent AJ, Mugo D, Musyimi R, Mutiso A, Morpeth S, Levin M, Scott JAGet al., 2017, Bacteriological diagnosis of childhood TB: a prospective observational study, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Dietz SM, van Stijn D, Burgner D, Levin M, Kuipers IM, Hutten BA, Kuijpers TWet al., 2017, Dissecting Kawasaki disease: a state-of-the-art review, EUROPEAN JOURNAL OF PEDIATRICS, Vol: 176, Pages: 995-1009, ISSN: 0340-6199

JOURNAL ARTICLE

Hemingway C, Berk M, Anderson ST, Wright VJ, Hamilton S, Eleftherohorinou H, Kaforou M, Goldgof GM, Hickman K, Kampmann B, Schoeman J, Eley B, Beatty D, Pienaar S, Nicol MP, Griffiths MJ, Waddell SJ, Newton SM, Coin LJ, Relman DA, Montana G, Levin Met al., 2017, Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function, PLOS ONE, Vol: 12, ISSN: 1932-6203

JOURNAL ARTICLE

Israel L, Wang Y, Bulek K, Della Mina E, Zhang Z, Pedergnana V, Chrabieh M, Lemmens NA, Sancho-Shimizu V, Descatoire M, Lasseau T, Israelsson E, Lorenzo L, Yun L, Belkadi A, Moran A, Weisman LE, Vandenesch F, Batteux F, Weller S, Levin M, Herberg J, Abhyankar A, Prando C, Itan Y, van Wamel WJB, Picard C, Abel L, Chaussabel D, Li X, Beutler B, Arkwright PD, Casanova J-L, Puel Aet al., 2017, Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity, CELL, Vol: 168, Pages: 789-+, ISSN: 0092-8674

JOURNAL ARTICLE

Kaforou M, Herberg JA, Wright VJ, Coin LJM, Levin Met al., 2017, Diagnosis of Bacterial Infection Using a 2-Transcript Host RNA Signature in Febrile Infants 60 Days or Younger, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 317, Pages: 1577-1578, ISSN: 0098-7484

JOURNAL ARTICLE

Kaufmann SHE, Dockrell HM, Drager N, Ho MM, McShane H, Neyrolles O, Ottenhoff THM, Patel B, Roordink D, Spertini F, Stenger S, Thole J, Verreck FAW, Williams Aet al., 2017, TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development, FRONTIERS IN IMMUNOLOGY, Vol: 8, ISSN: 1664-3224

JOURNAL ARTICLE

Shimizu C, Kim J, Eleftherohorinou H, Wright V, Hoang L, Tremoulet A, Franco A, Hibberd M, Takahashi A, Kubo M, Ito K, Tanaka T, Onouchi Y, Coin L, Levin M, Burns J, Shike Het al., 2017, Genetic Variants in HLA-C and Class I Pathway Genes Influence Susceptibility to Kawasaki Disease, Publisher: WILEY, ISSN: 2326-5191

CONFERENCE PAPER

Gliddon HD, Howes PD, Kaforou M, Levin M, Stevens MMet al., 2016, A nucleic acid strand displacement system for the multiplexed detection of tuberculosis-specific mRNA using quantum dots, NANOSCALE, Vol: 8, Pages: 10087-10095, ISSN: 2040-3364

JOURNAL ARTICLE

Herberg JA, Kaforou M, Wright VJ, Shailes H, Eleftherohorinou H, Hoggart CJ, Cebey-Lopez M, Carter MJ, Janes VA, Gormley S, Shimizu C, Tremoulet AH, Barendregt AM, Salas A, Kanegaye J, Pollard AJ, Faust SN, Patel S, Kuijpers T, Martinon-Torres F, Burns JC, Coin LJM, Levin Met al., 2016, Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 316, Pages: 835-845, ISSN: 0098-7484

JOURNAL ARTICLE

Levin M, Kaforou M, 2016, Predicting active tuberculosis progression by RNA analysis, LANCET, Vol: 387, Pages: 2268-2270, ISSN: 0140-6736

JOURNAL ARTICLE

Martinon-Torres F, Png E, Khor CC, Davila S, Wright VJ, Sim KS, Vega A, Fachal L, Inwald D, Nadel S, Carrol ED, Martinon-Torres N, Marcos Alonso S, Carracedo A, Morteruel E, Lopez-Bayon J, Concha Torre A, Calvo Monge C, Gonzalez de Aguilar PA, Esteban Torne E, del Carmen Martinez-Padilla M, Maria Martinon-Sanchez J, Levin M, Hibberd ML, Salas Aet al., 2016, Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

McDonald JU, Kaforou M, Clare S, Hale C, Ivanova M, Huntley D, Dorner M, Wright VJ, Levin M, Martinon-Torres F, Herberg JA, Tregoning JSet al., 2016, A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease, MSYSTEMS, Vol: 1, ISSN: 2379-5077

JOURNAL ARTICLE

Seaby EG, Wright VJ, Levin M, 2016, Genome-wide Association Studies in Infectious Diseases, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 35, Pages: 802-804, ISSN: 0891-3668

JOURNAL ARTICLE

Shimizu C, Eleftherohorinou H, Wright VJ, Kim J, Alphonse MP, Perry JC, Cimaz R, Burgner D, Dahdah N, Hoang LT, Khor CC, Salgado A, Tremoulet AH, Davila S, Kuijpers TW, Hibberd ML, Johnson TA, Takahashi A, Tsunoda T, Kubo M, Tanaka T, Onouchi Y, Yeung RSM, Coin LJM, Levin M, Burns JCet al., 2016, Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities, CIRCULATION-CARDIOVASCULAR GENETICS, Vol: 9, Pages: 559-+, ISSN: 1942-325X

JOURNAL ARTICLE

Davies S, Sutton N, Blackstock S, Gormley S, Hoggart CJ, Levin M, Herberg JAet al., 2015, Predicting IVIG resistance in UK Kawasaki disease, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 100, Pages: 366-368, ISSN: 0003-9888

JOURNAL ARTICLE

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